Application of total flavonoids of caragana sinica maxim in preparation of medicine for treating renal hypertension

A technology of renal hypertension and total flavonoids, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve wide practicability and development value, and the effect of improving blood pressure

Inactive Publication Date: 2020-10-30
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the application of the total flavonoid extract of the medicinal material gorse in the treatment of renal hypertension.

Method used

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  • Application of total flavonoids of caragana sinica maxim in preparation of medicine for treating renal hypertension
  • Application of total flavonoids of caragana sinica maxim in preparation of medicine for treating renal hypertension
  • Application of total flavonoids of caragana sinica maxim in preparation of medicine for treating renal hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: The use of total flavonoids of gorse in the preparation of drugs for the treatment of renal hypertension

[0029] The invention provides the use of the total flavonoids of broom in the preparation of medicines for treating renal hypertension.

[0030] For this use, the improvement is selected from one or more of the following symptoms: blood pressure, renal water and sodium retention, kidney damage, amino acid metabolic disorder, and lipid metabolic disorder.

[0031]For this purpose, the improvement is selected from one or more of the following indicators: systolic blood pressure level, plasma AngI level, plasma AngII level, plasma ALD level, serum NO level, degree of left renal artery stenosis, glutamine content , creatinine content, and inositol content were significantly reduced (P<0.05), cholesterol content, lipid content, valine content, citrulline content, proline content, and unsaturated fat content.

[0032] For this use, the severity of renal hyper...

Embodiment 2

[0040] Embodiment two: gorse total flavonoids extraction

[0041] 1. Experimental materials

[0042] Gorse was collected in Butterfly Valley, Shirengou, Urumqi, Xinjiang in May 2018. It was identified as Caragana altaica Kom. of whole grass.

[0043] 2. Ultrasonic extraction of total flavonoids from gorse

[0044] Dry and powder gorse flowers and pass through a 40-mesh sieve, weigh 1.00g, add 50mL of 60% ethanol solution, set the water bath temperature at 60°C, soak for 15min, ultrasonicate at 70°C for 50min, filter with suction, and take 1mL In a 10mL volumetric flask, the total flavonoids of gorse were obtained by crude extraction.

[0045] 3. Purification of total flavonoids from gorse

[0046] Soak the AB-8 macroporous resin in absolute ethanol for 24 hours, rinse it with twice-distilled water until the effluent is free from turbidity, then soak it in 5% hydrochloric acid for 3-4 hours, wash it with water until neutral, and finally wash it with 5% hydrogen Soak in sod...

Embodiment 3

[0048] Example 3: Preparation of rat model of renal hypertension with two kidneys and one clip

[0049] 1. Experimental animals

[0050] 90 male healthy SD rats, body weight (200±20) g, SPF grade, provided by the Experimental Animal Center of Xinjiang Medical University, experimental animal qualification certificate number SCXK (new) 2018-0003. The animals were kept in an SPF-grade experimental environment, and had free access to food and water.

[0051] 2. Test substance

[0052] Purified and dried dry powder with a content of 32.5%, dissolved in distilled water to prepare 400mg / kg (equivalent to 1250mg crude drug / kg), 200mg / kg (equivalent to 625mg crude drug / kg), 100mg / kg (equivalent to 312mg crude drug / kg) dose of the solution by intragastric administration.

[0053] 3. Experimental method

[0054] 3.1 Establishment of 2K1C renal hypertensive rat model

[0055] 90 SD rats were taken, fasted without food and water for 12 hours before the operation, and anesthetized by ...

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Abstract

The invention discloses an application of total flavonoids of caragana sinica maxim in preparation of a medicine for treating renal hypertension. The symptoms of blood pressure, kidney water and sodium retention, kidney injury, amino acid metabolic disorder and lipid metabolic disorder can be effectively improved; the systolic pressure level, the plasma Ang I level, the plasma Ang II level, the plasma ALD level, the serum NO level, the left renal artery stenosis degree, the glutamine content, the creatinine content and the inositol content are remarkably adjusted and remarkably reduced (P is less than 0.05); the indexes of cholesterol content, lipid content, valine content, citrulline content, proline content and unsaturated fat content have wide practicability and development value for developing new cardiovascular medicine resources and protecting traditional Chinese medicinal material resources.

Description

technical field [0001] The invention belongs to the field of medicinal material development, and relates to the preparation of medicines for treating renal hypertension, in particular to the total flavonoid extract of gorse flower extracted from medicinal material gorse, which can effectively treat renal hypertension. Background technique [0002] Gorse (Caragana sinica Rehd.) is the dry and mature flower of Caragana altaica Kom.Pojark, a species of Papilionaceae Caragana Fabr, which grows at an altitude of 1,000 meters in Altay, Xinjiang. In bushes, hillsides, and valleys below 1.5 meters, the amount of flower formation is large. Its medicinal parts are mostly roots, xylem, stems, and whole plants. Altai Caragana (namely gorse), as a kind of folk medicine, has been eaten by local residents. [0003] The main mechanism of hypertension leading to kidney disease and cardiovascular disease is the activation of the renin-angiotensin-aldosterone system. One of the ways to preve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P13/12A61P9/12
CPCA61K36/48A61P13/12A61P9/12
Inventor 姚军古丽斯坦·阿不来提沈静
Owner XINJIANG MEDICAL UNIV
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