Compound for targeted degradation of focal adhesion kinase and application of compound
A compound and hydrate technology, applied in the field of biomedicine and drug synthesis, can solve the problems of prone to drug resistance and unable to block the function of FAK skeleton
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Embodiment 1
[0111]
[0112] 1 H NMR (600MHz, CDCl 3 )δ10.00(s,1H),8.14(s,1H),7.51–7.48(m,1H),7.44 (d,J=5.8Hz,1H),7.39(d,J=8.7Hz,2H), 7.35–7.27(m,3H),7.18(d,J=7.1Hz,1H),6.97(s,1H),6.84(d,J=8.7Hz,2H),6.80(d,J=8.5Hz,1H ),6.70(t,J=5.7Hz,1H),5.96(s,1H),5.13(s,1H),4.90(dd,J=11.4,4.4Hz,1H),4.66(s,1H),3.94 (d,J=5.8Hz,2H),3.62–3.52(m,9H),3.45–3.42(m,1H),3.24(s,3H),3.15(s,4H),2.97(s,4H), 2.86–2.77(m,2H),2.72–2.64(m,6H),2.11(dd,J=8.8,3.9Hz, 1H).HRMS calcd for C 45 h 52 f 3 N 11 o 9 S,[M+H] + ,980.3695; found 980.3712.
Embodiment 2
[0114]
[0115] 1 H NMR (600MHz, CDCl 3 )δ10.76(s,1H),8.14(s,1H),7.72(s,1H),7.50–7.46(m,1H),7.45–7.41(m,3H),7.34–7.27(m,3H) ,7.08(d,J=7.1Hz,1H),6.97(d,J=8.6Hz,1H),6.82(d,J=8.7Hz,3H),6.41(t,J=4.9Hz,1H),5.99 (s,1H),5.12(s,1H),4.88(dd,J=12.0,5.4Hz,1H),4.65(d,J=11.3Hz,1H),3.66(t,J=5.6Hz, 2H) ,3.51–3.44(m,6H),3.22(s,3H),3.15(s,4H),2.96(s,3H),2.80–2.65(m,7H), 2.50–2.46(m,4H),2.09 (dd,J=7.8,5.3Hz,1H),1.82–1.78(m,2H).HRMS calcd for C 45 h 52 f 3 N 11 o 8 S,[M+H] + ,964.3746; found 964.3788.
Embodiment 3
[0117]
[0118] 1 H NMR (600MHz, CDCl 3 )δ10.40(s,1H),8.15(s,1H),7.71(s,1H),7.49–7.45(m,1H),7.44(d,J=6.6Hz,1H),7.40(d,J =9.0Hz, 2H), 7.34–7.27(m, 3H), 7.09 (d, J=7.1Hz, 1H), 6.90(d, J=8.6Hz, 1H), 6.85(d, J=8.9Hz, 2H ),6.52(t,J=5.5Hz,1H),6.00(s,1H),5.13(s,1H),4.87(dd,J=11.5,4.1Hz,1H),4.64(d,J=11.5Hz ,1H),3.73–3.69(m,4H),3.67–3.64(m,4H),3.47–3.44(m,2H),3.22(s,3H), 3.17(s,4H),2.96(s,3H ),2.80–2.65(m,9H),2.10–2.06(m,1H).HRMS calcd for C 43 h 49 f 3 N 10 o 8 S,[M+H] + ,923.3480; found 923.3513.
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