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Tripterygium wilfordii source compound and application and preparation method thereof, pharmaceutical composition and insecticide

A technology of pharmaceutical composition and compound, which is applied in the field of insecticidal application, compound and its medical application, and can solve the problems such as unstoppable search

Active Publication Date: 2020-11-10
上海诗丹德标准技术服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to find more ideal anticancer compounds, people have not stopped looking for plant-derived compounds with anticancer activity

Method used

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  • Tripterygium wilfordii source compound and application and preparation method thereof, pharmaceutical composition and insecticide
  • Tripterygium wilfordii source compound and application and preparation method thereof, pharmaceutical composition and insecticide
  • Tripterygium wilfordii source compound and application and preparation method thereof, pharmaceutical composition and insecticide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1: The compound of the present invention has the inhibitory effect on the proliferation of cancer cells

[0063] Test method: The generation of tumor is the result of loss of cell function regulation. Abnormal growth signal and cell cycle regulation will lead to abnormal cell proliferation and eventually produce malignant clones. So one of the characteristics of cancer cells is abnormal proliferation. Inhibiting the proliferation of cancer cells is one of the important ways to treat cancer, and it is also the basic requirement of antitumor drugs. After the new compounds were applied to human liver cancer cell Huh7, human colon cancer cell KSW480, human prostate cancer cell DU145, human non-small cell lung cancer A549 and human breast cancer cell MCF-7 for 24 hours, they were detected at 450nm by the CCK-8 method. The absorbance value was measured to detect the inhibitory effect on cancer cell proliferation.

[0064] Huh7, SW480, DU145, A549 and MCF-7 cell...

Embodiment 2

[0070] Embodiment 2: the insecticidal effect of the compound of the present invention

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PUM

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Abstract

The invention provides a novel sesquiterpene compound, the structure of which is represented by the following formula (I), and the invention also relates to a preparation method of the compound. The novel compound has very clear anti-tumor activity and insecticidal activity.

Description

technical field [0001] The present invention relates to a compound and its medical application and insecticidal application, and also relates to a pharmaceutical composition and an insecticide containing the compound. Background technique [0002] Malignant tumor is one of the three major diseases that endanger human health, with high morbidity and mortality. Modern western medicine treatment is mainly based on chemotherapy, which has relatively high toxicity and side effects, and the quality of life of patients is significantly reduced. Traditional Chinese medicine has unique advantages in anti-cancer and anti-cancer, reducing adverse reactions, etc., and is a treasure house for the development of new anti-tumor drugs. At present, the anti-cancer preparations derived from Chinese herbal medicines account for more than 30% of the total anti-cancer drugs, such as taxanes, camptothecin, vincristine, etc., which have been used as the first-choice anti-tumor drugs. [0003] Tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/00A61K31/343A01N43/08A61P35/00A01P7/04
CPCC07D307/00A01N43/08A61P35/00Y02A50/30
Inventor 钱勇陈华保李雪松潘雪格诸晨谢天培
Owner 上海诗丹德标准技术服务有限公司