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Application of phenylthiazine and its salts in the preparation of antitumor drugs

An anti-tumor drug, the technology of phenylthiazine, applied in the field of biomedicine, can solve the problems of no reports

Active Publication Date: 2022-01-07
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the effect of this drug on inhibiting the proliferation and growth of esophageal cancer, and there is no related patent application

Method used

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  • Application of phenylthiazine and its salts in the preparation of antitumor drugs
  • Application of phenylthiazine and its salts in the preparation of antitumor drugs
  • Application of phenylthiazine and its salts in the preparation of antitumor drugs

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0025] application test

[0026] Materials and Methods

[0027] 1. Materials

[0028] 1.1 Cells and Reagents

[0029] Esophageal squamous cell carcinoma cells KYSE150 and KYSE450 come from the Department of Pathophysiology, School of Basic Medicine, Zhengzhou University. The present invention uses a human esophageal carcinoma tissue specimen, numbered EG20. The patient was from Henan Cancer Hospital, male, 46 years old, case stage T2N0M0II, moderately differentiated.

[0030] Pizothiazine Malate Powder American ABMOLE

[0031] Penicillin North China Pharmaceutical Co., Ltd.

[0032] Streptomycin Shandong Lukang Pharmaceutical Co., Ltd.

[0033] RPMI-1640 Medium Israel Biological Industries Company

[0034] DMEM medium Biological Industries, Israel

[0035] 0.25% tr...

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PUM

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Abstract

The invention discloses the application of phenylthiazine and its salts in the preparation of antitumor drugs, especially the application of phenylthiazine and phenylthiazine malate (molecular formula: C 23 h 27 NO 5 S, molecular weight: 429.53, CAS number: 5189-11-7) in the preparation of anti-tumor drugs, the anti-tumor drugs are drugs for the treatment of esophageal cancer. This application has confirmed through experiments that phenothiazine malate can inhibit the growth and transformation of esophageal squamous cell carcinoma cells when it is used in esophageal squamous cell carcinoma cells (KYSE150 cells, KYSE450 cells). The appropriate concentration of salt that can inhibit the proliferation and transformation of esophageal squamous cell carcinoma cells is 2.5 μM-20 μM.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of phenylthiazine and its salt in the prevention and treatment of tumors. Background technique [0002] According to the statistics of the World Health Organization (WHO), there are more than 14 million newly diagnosed cancer patients and 8 million cancer-related deaths every year. The top 10 cancers worldwide are lung cancer (13%), breast cancer (11.9%), colorectal cancer (9.7%), prostate cancer (8%), stomach cancer (6.8%), liver cancer (5.5%) , cervical cancer (3.7%), esophageal cancer (3.2%), bladder cancer (3%) and non-Hodgkin's lymphoma (2.7%). Globally, there are approximately 1.4 million new cases of upper gastrointestinal malignant tumors (esophageal cancer and gastric cancer) each year, and approximately 1.12 million deaths, second only to lung cancer. Among the new cases of upper gastrointestinal malignant tumors, 74.36% occurred in underdeveloped...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4535A61P35/00
CPCA61K31/4535A61P35/00
Inventor 刘康栋董子钢何鑫宇赵继敏江亚南
Owner ZHENGZHOU UNIV