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Method, system and device for prevention and assessment of postoperative cognitive impairment

A technology for cognitive dysfunction and evaluation model, which can be used in psychological devices, medical science, diagnostic signal processing, etc., and can solve problems such as unclearness

Pending Publication Date: 2020-11-20
FUDAN UNIV SHANGHAI CANCER CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some drugs for the treatment of mental illness such as chlorpromazine can be used to treat POD after surgery, but whether it can prevent POCD is not clear, and there are some side effects

Method used

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  • Method, system and device for prevention and assessment of postoperative cognitive impairment
  • Method, system and device for prevention and assessment of postoperative cognitive impairment
  • Method, system and device for prevention and assessment of postoperative cognitive impairment

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Embodiment Construction

[0043] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0044] In the following description, references to "some embodiments" describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or a different subset of all possible embodiments, and Can be combined with each other without conflict.

[0045] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to w...

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Abstract

The invention provides a method, system and device for prevention and assessment of postoperative cognitive impairment. Patients subjected to non-cardiac non-nerve surgical operations under general anesthesia are randomly divided into a testing group and a control group, wherein the testing group accepts methylene blue intravenous injection, and the control group is subject to intravenous injection of normal saline; neuropsychology tests are conducted on the testing group and the control group, and the neuropsychology tests include delirium assessment and cognition assessment; blood analysis is conducted on the patients in the testing group and the control group, and changes in superoxide dismutase and homocysteine are tested; and according to results of the neuropsychology tests, assessment models are established to compare differences of blood levels between the testing group and the control group as well as occurrence rates of postoperative delirium and postoperative cognitive impairment.

Description

technical field [0001] The invention relates to the application of methylene blue in the field of prevention of cognitive dysfunction, in particular to a method, system and device for postoperative cognitive dysfunction prevention evaluation. Background technique [0002] Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common postoperative complications of the central nervous system in elderly patients, leading to prolonged hospital stay, postoperative mortality and increased medical costs. At present, there is a relatively high proportion of elderly malignant tumor surgery patients. At present, intraoperative administration of hormones, non-steroidal anti-inflammatory drugs, and dexmedetomidine (DEX) are considered to prevent the incidence of postoperative neurocognitive impairment in elderly patients. However, clinical results are controversial. Some drugs for the treatment of mental illness such as chlorpromazine can be used to treat POD a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/16A61B5/00
CPCA61B5/165A61B5/4848A61B5/4088A61B5/72
Inventor 张军邓益旭
Owner FUDAN UNIV SHANGHAI CANCER CENT
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