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Chemically guided ambient ionisation mass spectrometry

An open, chemical technique used in the field of ion mobility spectrometry and/or mass analyzers, ion mobility spectrometry and/or mass analysis, to achieve the effect of improving survival

Pending Publication Date: 2020-11-27
MICROMASS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in many cases, it is very difficult to completely remove the cancer without compromising vital functions, and accurately determining the margins of the cancerous tissue when performing brain tumor resection is a challenge

Method used

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  • Chemically guided ambient ionisation mass spectrometry
  • Chemically guided ambient ionisation mass spectrometry
  • Chemically guided ambient ionisation mass spectrometry

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Embodiment Construction

[0270] Various embodiments will now be described in more detail below that generally involve obtaining chemical or other non-mass spectrometric data from one or more regions of a target (e.g., tissue in the body) and then One or more areas of the device generate aerosols, surgical smoke or vapor.

[0271] The aerosols, surgical smoke or vapors are then ionized by impact ionization by aspirating them into the vacuum chamber of the mass spectrometer and striking the collision surface, which results in the generation of analyte ions.

[0272] These resulting analyte ions (or fragments or product ions derived from the analyte ions) are then subjected to mass spectrometry followed by multivariate analysis of the resulting mass spectrometry data and / or ion mobility data to identify targets in real time one or more properties.

[0273] For example, the multivariate analysis may enable a determination of whether a portion of the currently resected tissue is cancerous.

[0274] The u...

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Abstract

A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target (2) using a chemical sensor (20). The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target (2). An ambient ionisation ion source (1) may then be used to generate aerosol, smoke or vapour (5) from one or more regions of the target (2).

Description

[0001] Cross References to Related Applications [0002] This application is a divisional application with an application date of March 7, 2016, an application number of 201680025647.7 (PCT / GB2016 / 050608), and an invention title of "Chemical-Guided Open Ionization Mass Spectrometry". [0003] This application claims UK Patent Application No. 1503876.3 filed March 6, 2015, UK Patent Application No. 1503864.9 filed March 6, 2015, UK Patent Application No. 1518369.2 filed October 16, 2015, 2015 UK Patent Application No. 1503877.1 filed March 6, 2015 UK Patent Application No. 1503867.2 filed March 6, 2015 UK Patent Application No. 1503863.1 filed March 6, 2015, March 6, 2015 Priority and benefit to UK Patent Application No. 1503878.9 filed, UK Patent Application No. 1503879.7 filed 6 March 2015 and UK Patent Application No. 1516003.9 filed 9 September 2015. The entire contents of these applications are hereby incorporated by reference. technical field [0004] The present invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/20A61B17/32A61B10/00A61B10/02A61B18/14G01N21/65G01N33/68
CPCA61B10/02A61B17/00A61B17/32A61B18/00A61B18/14A61B18/20G01N3/00G01N9/00G01N33/68G01N33/92H01J49/00H01J49/04H01J49/06H01J49/16G01N27/622G01N33/6848H01J49/0036H01J49/0404H01J49/0459H01J49/068A61B2218/008A61B10/0233A61B10/0283A61B17/320068G16B20/00H01J49/049A61B10/0041A61B2010/0083A61B10/00A61B18/1445G01N33/6851H01J49/164G01N27/624G01N30/724H01J49/0445H01J49/0468H01J49/061H01J49/10H01J49/14H01J49/24H01J49/26A61B2017/320069A61B18/042A61B18/1815A61B2018/00577A61F13/38G01N33/487H01J49/0031H01J49/0004H01J49/0463G16H50/20H01J49/0422A61B1/00013A61B1/041A61B1/31A61B5/0066A61B5/0075C12Q1/025C12Q1/04C12Q1/18C12Q1/24G01N1/2202G01N2001/2223G01N2333/195G01N2405/00G01N2405/04G01N2405/08G01N2570/00G01N2800/26A61B5/015A61B5/0507A61B5/055A61B5/14542A61B6/032A61B6/037A61B8/13A61B90/13H01J49/025G01N33/48735A61B1/2736A61B18/04A61B2018/00589A61B2018/00994A61B2218/002H01J49/0027H01J49/0409G16H10/40G16H15/00
Inventor 史蒂文·德里克·普林格尔埃姆里斯·琼斯迈克尔·雷蒙德·莫里斯茱莉亚·巴洛格詹姆斯·伊恩·兰格里奇基思·理查森丹尼尔·西蒙拉约什·高迪尔海兹丹尼尔·绍洛伊佐尔坦·塔卡茨
Owner MICROMASS UK LTD
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