A panel of plasma protein markers for predicting the risk of metastasis in nasopharyngeal carcinoma

A marker, nasopharyngeal cancer technology, applied in the field of biomarkers, can solve the problems of differences, inability to completely accurately predict the risk of metastasis and prognosis of patients with nasopharyngeal cancer, and high toxicity and side effects of chemotherapy, so as to achieve good clinical drug use, prediction Metastatic risk and prognostic effects

Active Publication Date: 2022-07-01
SUN YAT SEN UNIV CANCER CENT
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  • Abstract
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Problems solved by technology

However, patients with the same stage and similar levels of EBV before treatment, after receiving the same standard treatment, there is also a large difference in whether metastasis occurs
Obviously, TNM clinical staging and pre-treatment EBV-DNA levels based on anatomical information alone cannot accurately predict the metastasis risk and prognosis of patients with nasopharyngeal carcinoma
At the same time, TNM clinical staging and pre-treatment EBV-DNA levels cannot be used to guide individualized medication, resulting in the current chemotherapy efficacy rate for patients with metastatic nasopharyngeal carcinoma being only 40-65%, and chemotherapy toxicity is high

Method used

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  • A panel of plasma protein markers for predicting the risk of metastasis in nasopharyngeal carcinoma
  • A panel of plasma protein markers for predicting the risk of metastasis in nasopharyngeal carcinoma
  • A panel of plasma protein markers for predicting the risk of metastasis in nasopharyngeal carcinoma

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Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Screening of markers

[0031] Identification of proteins associated with metastasis-free survival in nasopharyngeal carcinoma:

[0032] The inventors used the customized Raybiotech Quantibody Array protein chip technology platform to detect these 50 differentially expressed genes in 226 specimens, and used univariate Cox analysis to screen out 18 plasma proteins related to the survival of nasopharyngeal carcinoma without distant metastasis.

[0033] Discovery of metastatic protein markers in nasopharyngeal carcinoma:

[0034] The inventor used the LASSO-Cox model to further select five proteins to form a set of markers, including: SLAMF5, ESM-1, MMP-8, INSR, Serpin A5, and named these five protein markers as PSDM (protein-based signature for distant metastasis in LA-NPC, locally advanced nasopharyngeal carcinoma distant metastasis protein signature).

[0035] The scoring formula used by the markers to predict the risk of nasopharyngeal carcinoma metastasis i...

Embodiment 2

[0038] Example 2 Efficacy test of protein markers

[0039] The inventors then compared the efficacy of the combination of protein markers in predicting distant metastasis of nasopharyngeal carcinoma with individual proteins, N stage, and EBV-DNA levels. Time-dependent ROC curves showed that the protein marker combination was more potent than each individual protein at the 5-year time point (C-index: 0.76, 95% CI 0.67-0.85; P image 3 A), while the time-dependent AUC analysis showed that the combined efficacy of protein markers was always better than that of each individual protein over a continuous 7-year time span (P image 3 B). Similarly, we also found that protein markers were better than N stage and pre-treatment EBV-DNA levels in predicting NPC metastasis at 5-year time points and continuous time points (P image 3 C-D).

[0040] In addition, the inventors also analyzed whether DMGN can predict the benefit of induction chemotherapy with docetaxel + cisplatin + 5-fluorour...

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Abstract

The invention discloses a group of plasma protein markers for predicting the risk of nasopharyngeal carcinoma metastasis and its application. Markers include SLAMF5, ESM‑1, MMP‑8, INSR, Serpin A5. The protein tags formed by the expression of five proteins in the present invention can reflect the biological specificity of nasopharyngeal carcinoma patients, can more accurately predict the metastasis risk and prognosis of nasopharyngeal carcinoma patients, better guide clinical medication, and have a positive impact on patients without distant survival. The predictive power was better than that of individual proteins, tumor N stage and EBV‑DNA levels.

Description

technical field [0001] The present invention relates to the technical field of biomarkers, and more particularly, to a group of plasma protein markers for predicting the risk of nasopharyngeal carcinoma metastasis. Background technique [0002] Nasopharyngeal carcinoma (NPC) is an aggressive malignant tumor of the head and neck. About 40% of the world's cases occur in my country, and in my country, the incidence is the highest in southern China such as Guangdong Province. Nasopharyngeal carcinoma is most common in young adults, and 70% of the patients are in the middle and late stages when they first visit a doctor, which brings a heavy burden to the patient's family and poses a serious threat to the life and health of the Chinese people. In recent years, with the application of modern imaging technology, the advancement of radiotherapy technology, and the application of comprehensive radiotherapy and chemotherapy strategies, the local control rate of nasopharyngeal carcinom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57407G01N33/57488G01N33/6893G01N2800/50
Inventor 马骏柳娜黎映琴梁叶琳唐玲珑陈磊毛燕萍何庆梅杨晓静
Owner SUN YAT SEN UNIV CANCER CENT
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