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Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing fatty liver diseases

A fatty liver disease and composition technology, applied in the field of medicine, can solve the problems of lack of effective treatment of NAFLD, incomplete elucidation of the pathogenesis of NAFLD, etc., and achieve significant therapeutic and/or preventive effects and good synergistic effects.

Active Publication Date: 2020-12-01
吴铁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis of NAFLD has not been fully elucidated, and effective treatments for NAFLD are lacking

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing fatty liver diseases
  • Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing fatty liver diseases
  • Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing fatty liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1) Chinese medicine composition formula (by weight):

[0041]

[0042] 2) Preparation method:

[0043] (1) Extract 2 times of Zhongdan Shen Gardenia plus 80% ethanol in the prescription ratio, add 5 times the amount of 80% ethanol for 2 hours for the first time, add 4 times the amount of 80% ethanol for 1.5 hours for the second time, filter , and the dregs are collected in another device for use; the two filtrates before and after merging, the ethanol is recovered under reduced pressure to a clear ointment with a relative density of about 1.20 (70°C), for use;

[0044] (2) Pulverize the Poria cocos of 1 / 10 prescription quantity and pass through a 100-mesh sieve, sieve out the fine powder, and the remaining coarse grains will be used separately;

[0045] (3) Add raw malt, Digupi, Laifuzi, Taizi to participate in the rest of the prescription amount of Poria cocos and the pulverized coarse grains of Poria cocos in the prescription ratio, add 7 times the amount of water...

Embodiment 2

[0050] 1) Chinese medicine formula (by weight):

[0051]

[0052] 2) Preparation method:

[0053] (1) Extract 2 times of Zhongdan Shen Gardenia plus 80% ethanol in the prescription ratio, add 5 times the amount of 80% ethanol for 2 hours for the first time, add 4 times the amount of 80% ethanol for 1.5 hours for the second time, filter , and the dregs are collected in another device for use; the two filtrates before and after merging, the ethanol is recovered under reduced pressure to a clear ointment with a relative density of about 1.20 (70°C), for use;

[0054] (2) Pulverize the Poria cocos of 1 / 10 prescription quantity and pass through a 100-mesh sieve, sieve out the fine powder, and the remaining coarse grains will be used separately;

[0055] (3) Add raw malt, Digupi, Laifuzi, Taizi to participate in the rest of the prescription amount of Poria cocos and the pulverized coarse grains of Poria cocos in the prescription ratio, add 7 times the amount of water to decoct f...

preparation Embodiment 3

[0060] 1) Chinese medicine composition formula (by weight)

[0061]

[0062] 2) accessories (by weight)

[0063] Beta cyclodextrin 0.04

[0064] Cornstarch 3% (based on the amount of the blend)

[0065] Talc 0.8% (based on the amount of the total blend)

[0066] 3) Preparation method

[0067] (1) Extract 2 times of Zhongdan Shen Gardenia plus 80% ethanol in the prescription ratio, add 5 times the amount of 80% ethanol for 2 hours for the first time, add 4 times the amount of 80% ethanol for 1.5 hours for the second time, filter , and the dregs are collected in another device for use; the two filtrates before and after merging, the ethanol is recovered under reduced pressure to a clear ointment with a relative density of about 1.20 (70°C), for use;

[0068] (2) Pulverize the Poria cocos of 1 / 10 prescription quantity in the prescription and pass through a 100-mesh sieve, sieve out the fine powder, and the remaining coarse grains are set aside;

[0069] (3) Add raw malt, ...

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Abstract

The invention relates to the field of medicine, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for treating or preventing fatty liver diseases,and the traditional Chinese medicine composition is composed of cape jasmine, poria cocos, radix salviae miltiorrhizae, cortex lycii radicis, radix pseudostellariae, fructus amomi, raw malt and semenraphani. The traditional Chinese medicine composition can effectively treat or prevent fatty liver diseases; experiments prove that the traditional Chinese medicine composition disclosed by the invention has a remarkable treatment and / or prevention effect on the non-alcoholic fatty liver disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of medicaments for treating fatty liver. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) refers to the excessive deposition of fat in liver cells caused by excluding alcohol and other definite liver damage factors. NAFLD is a common liver disease of increasing global health concern with an estimated global prevalence of 25.2%. It includes a broad spectrum of disease, from simple steatosis to nonalcoholic steatohepatitis (NASH), which may lead to advanced fibrosis, cirrhosis or its associated complications, and hepatocellular carcinoma. In western countries, people's observation and research on NAFLD is the most common, and its prevalence rate is 24-46%. Recently, the prevalence of NAFLD in Asia has been increasing rapidly with the improvement of living standards and changes in lifesty...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/36A61P1/16
CPCA61K36/744A61K36/076A61K36/537A61K36/815A61K36/36A61K36/9064A61K36/8998A61K36/31A61K9/2068A61K47/6951A61K9/286A61P1/16A61K2236/333A61K2236/39A61K2236/331A61K2300/00
Inventor 吴铁袁孟峰王嘉豪麦龙儿
Owner 吴铁