A kind of reinforced dental resin filler based on hollow mesoporous silicon microspheres and its preparation method and application

A hollow mesoporous, silicon microsphere technology, applied in the field of biomedical engineering, can solve problems such as patient allergies, and achieve the effects of prolonging the release time, increasing the load, and improving the mechanical properties

Active Publication Date: 2021-11-23
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have confirmed the in vitro cytotoxicity of resin monomers (Atalayin C, et al.Dent MaterJ, 2015; 34(6):766–773.); and the unpolymerized free monomers will gradually leach from the resin cement, Causing cellular inflammatory response or toxic oxidative stress, causing allergy, postoperative pain or toxic reaction in patients (Da F, et al. Clin Oral Investig, 2016; 20(7): 1559–1566; Bakopoulou A, et al. Int J Mol Sci, 2009; 10(9):3861–3899.)

Method used

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  • A kind of reinforced dental resin filler based on hollow mesoporous silicon microspheres and its preparation method and application
  • A kind of reinforced dental resin filler based on hollow mesoporous silicon microspheres and its preparation method and application
  • A kind of reinforced dental resin filler based on hollow mesoporous silicon microspheres and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A method for preparing a reinforced dental resin filler based on hollow mesoporous silicon microspheres is provided, and the specific steps are as follows:

[0033] (1) At room temperature, add 250 mg of surface amination-modified positively charged polystyrene microspheres to a beaker filled with 30 mL of ethanol to disperse, and ultrasonicate for 5 minutes at a power of 400 W to obtain liquid I;

[0034] (2) Place liquid I on a magnetic stirrer at a stirring speed of 200 rpm and stir for 15 minutes, heat to 50°C, then add 2.50 mL of concentrated ammonia water to obtain liquid II;

[0035] (3) Weigh 0.65 g of tetraethyl silicate and add it to liquid II, place it on a magnetic stirrer and continue stirring for 1 hour to obtain liquid III of the suspension;

[0036] (4) Centrifuge liquid III at 4000 rpm, wash repeatedly with deionized water and absolute ethanol until the pH value of the washing liquid is between 7 and 7.5, filter the suspension, dry it in vacuum, and cal...

Embodiment 2

[0041] A method for preparing a reinforced dental resin filler based on hollow mesoporous silicon microspheres is provided, and the specific steps are as follows:

[0042] (1) At room temperature, add 500 mg of surface amination-modified positively charged polystyrene microspheres into a beaker filled with 60 mL of ethanol to disperse, and ultrasonicate for 5 minutes at a power of 400 W to obtain liquid I;

[0043] (2) Place liquid I on a magnetic stirrer at a stirring speed of 200 rpm and stir for 15 minutes, heat to 50°C, and then add 4.50 mL of concentrated ammonia water to obtain liquid II;

[0044] (3) Weigh 1.50 g of tetraethyl silicate and add it into liquid II, place it on a magnetic stirrer and continue stirring for 1 hour to obtain liquid III of the suspension;

[0045] (4) Centrifuge liquid III at 4000 rpm, wash repeatedly with deionized water and absolute ethanol until the pH value of the washing liquid is between 7–7.5, filter the suspension, dry it in vacuum, and...

Embodiment 3

[0055] A method for preparing a reinforced dental resin filler based on hollow mesoporous silicon microspheres is provided, and the specific steps are as follows:

[0056] (1) At room temperature, add 1000 mg of surface amination-modified positively charged polystyrene microspheres into a beaker filled with 120 mL of ethanol to disperse, and ultrasonicate for 5 minutes at a power of 400 W to obtain liquid I;

[0057] (2) Place liquid I on a magnetic stirrer at a stirring speed of 200 rpm and stir for 15 minutes, heat to 55°C, and then add 9.8 mL of concentrated ammonia water to obtain liquid II;

[0058] (3) Weigh 3.50 g of tetraethyl silicate and add it into liquid II, place it on a magnetic stirrer and continue stirring for 1 hour to obtain liquid III of the suspension;

[0059] (4) Centrifuge liquid III at 4000 rpm, wash repeatedly with deionized water and absolute ethanol until the pH value of the washing liquid is between 7 and 7.5, filter the suspension, dry it in vacuum...

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Abstract

The invention discloses a reinforced dental resin filler based on hollow mesoporous silicon microspheres, a preparation method and application thereof. The resin filler is a hollow mesoporous silicon microsphere loaded with resveratrol, and the resveratrol is evenly loaded on the inside and the surface of the hollow mesoporous silicon microsphere. Its preparation is as follows: (1) using positively charged polystyrene microspheres modified by surface amination as a template, and using tetraethyl silicate as a silicon source, calcining to obtain hollow mesoporous silicon microspheres; (2) protecting from light Dissolve resveratrol powder in absolute ethanol, add hollow mesoporous silicon microspheres under stirring, ultrasonically disperse, then place on a vibrating shaker for 24-48 hours and post-treatment to obtain the reinforcement based on hollow mesoporous silicon microspheres. type dental resin fillings. The resin filler has stable structure, uniform particle size, good dispersibility, high loading rate of drug resveratrol, long release time, simple preparation, and can effectively improve the biocompatibility, mechanical properties and resistance of resin cement when used in resin cement. Aging performance.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a reinforced dental resin filler based on hollow mesoporous silicon microspheres, a preparation method and application thereof. Background technique [0002] The ability of resin cements to bond indirect restorations to the tooth structure is key to the success of clinical dental restorations. At present, the short-term bonding strength between resin cement and dentin interface can basically meet clinical needs, but its durability is insufficient, biocompatibility is not good, and it is easy to cause problems such as microcracks and secondary caries, which eventually lead to restoration failure (Almeida R, et al. JProsthet Dent 2015; 114(2):272–277; Wataha C, et al. Clin Oral Invest, 1999; 3(3):144–149.), which has become an urgent problem in the field of dental restoration . [0003] Resin cement mainly contains inorganic filler particles and resin matrix, which can under...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/76A61K6/69A61K6/887
CPCA61K6/69A61K6/76A61K6/887C08L35/02
Inventor 黄翠颜惠宜杨宏业何婵喻健
Owner WUHAN UNIV
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