Application of betulinic acid derivatives in preparation of anti-liver lesion medicines

Abstract

The invention belongs to the field of medicines, and discloses betulinic acid derivatives or pharmaceutically acceptable salts thereof, and application of the betulinic acid derivatives or pharmaceutically acceptable salts thereof in preparation of anti-liver lesion medicines. The betulinic acid is successfully subjected to structural modification by a microbial conversion technology, a pluralityof novel compounds are obtained, and in-vitro anti-hepatic fibrosis cell tests prove that the compounds have better anti-hepatic fibrosis activity, can be used as active ingredients of anti-hepatic fibrosis medicines and have wide application.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of betulinic acid derivatives in the preparation of anti-hepatopathy drugs. Background technique [0002] Hepatic fibrosis is caused by various pathogenic factors leading to liver injury. Hepatic stellate cells are activated to become myofibroblast-like cells with a strong ability to generate extracellular matrix, and then the production of collagenase inhibitors increases and collagenase activity decreases. , so that the ratio between the production and degradation of extracellular matrix in the liver is out of balance, which eventually leads to the excessive deposition of liver collagen and liver fibrosis. Liver fibrosis continues to deteriorate and lead to liver cirrhosis and even liver cancer, so the chain of "hepatitis-hepatic fibrosis-liver cirrhosis-liver cancer" is recognized as a common path for various chronic liver diseases to lead to serious consequences. Stud...

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Problems solved by technology

At present, there are few reports on the anti-hepatic fibrosis effect of betulinic acid and its derivatives, and the pentacyclic triterpenoids have a special structure, the mother nucleus lacks active groups, and there are few reaction sites, so it is difficult to prepare them by conventional chemical reaction methods. Derivatives that meet the requirements

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