Method for rapidly optimizing traditional Chinese medicine formula and application of traditional Chinese medicine formula in drug-resistant tuberculosis resistance
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An optimization method and technology for tuberculosis, applied in microorganism-based methods, biochemical equipment and methods, pharmaceutical formulations, etc., can solve the problems of difficult clinical application of traditional Chinese medicine, unclear mechanism of action, complex traditional Chinese medicine ingredients, etc., and achieve safe and non-toxic side effects. , the effect of sufficient raw materials and low cost
Active Publication Date: 2020-12-04
CAPITALBIO CORP
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However, at present, the complex ingredients of traditional Chinese medicine, unclear toxicology, and unclear mechanism of action are the ke
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Embodiment 1
[0053] Embodiment 1, ancient prescription optimization
[0054] Taking the ancient prescription Poyin Wan (from the Song Dynasty "Three Causes, Extremes and One Syndrome Prescriptions") as an example for optimization, the names of Chinese medicines in the prescription refer to the names of "Chinese Pharmacopoeia" for unified standardization:
[0055] 10 parts of longan, 10 parts of clove, 10 parts of amomum, 10 parts of pepper, 10 parts of black plum, 10 parts of green skin, 10 parts of croton, 10 parts of woody fragrance, 10 parts of scorpion.
[0056] 1. Preparation of traditional Chinese medicine ethanol extract
[0057] Weigh each single drug in the prescription to be extracted, add 90% ethanol with a weight-to-volume ratio of 1:15, and use a Soxhlet extractor to heat and reflux for 3 hours. After filtering, the extract is concentrated at 45°C to an extract, and then frozen After drying for 24 hours, the prescription alcohol extract and the single drug alcohol extract wer...
Embodiment 2
[0088] Embodiment 2, Agada medicine optimization
[0089] The following is an example of the ancient prescription Agatha medicine (from Tang Dynasty "Qianjinyi") for optimization, and the names of Chinese medicines in the prescription refer to the names of "Chinese Pharmacopoeia" for unified standardization:
[0090] 10 parts of red sandalwood, 10 parts of three needles, 10 parts of madder, 10 parts of turmeric, and 10 parts of pepper.
[0091] 1. Preparation of traditional Chinese medicine ethanol extract
[0092] Weigh each single drug in the prescription to be extracted, add 90% ethanol with a weight-to-volume ratio of 1:15, and use a Soxhlet extractor to heat and reflux for 3 hours. After filtering, the extract is concentrated at 45°C to an extract, and then frozen After drying for 24 hours, the prescription alcohol extract and the single drug alcohol extract were obtained.
[0093] 2. Anti-tuberculosis experiment of traditional Chinese medicine ethanol extract
[0094]...
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Abstract
The invention discloses a method for rapidly optimizing a traditional Chinese medicine formula and application of the traditional Chinese medicine formula in drug-resistant tuberculosis resistance. The method for optimizing the drug-resistant tuberculosis formula comprises the following steps: respectively performing alcohol extraction on an existing tuberculosis formula and single medicines consisting of the tuberculosis formula, thereby obtaining a formula alcohol extract and a single medicine alcohol extract; respectively performing tubercle bacillus antibacterial effect detection on the formula alcohol extract and the single medicine alcohol extract, thereby obtaining the minimum antibacterial concentration of the existing tuberculosis formula and the single medicines; selecting the following single medicines which meet any condition for compounding, thereby obtaining the optimized tuberculosis formula: the single medicine of which the minimum antibacterial concentration is less than or equal to 500 and which is non-toxic, and the single medicine of which the minimum antibacterial concentration is greater than 500 and which is non-toxic when entering lung channels; and expanding drug-resistant bacterium detection of the optimized tuberculosis formula, thereby obtaining an improved formula, namely the drug-resistant tuberculosis formula, which has an obvious antibacterial effect compared with the existing tuberculosis formula. The obtained drug-resistant tuberculosis formula has an obvious antibacterial effect on tubercle bacillus, particularly drug-resistant tubercle bacillus, can be effectively used for treating pulmonary tuberculosis, particularly drug-resistant pulmonary tuberculosis and the like, and is safe and free of toxic or side effect.
Description
technical field [0001] The invention relates to a method for quickly optimizing the prescription of traditional Chinese medicine and its application in anti-drug-resistant tuberculosis. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection, which is mainly transmitted through the respiratory tract. It is one of the diseases with the longest history and serious consequences that endanger human life and health. With the application of antibiotics, drug-resistant tuberculosis has gradually become a difficult problem in the prevention and control of tuberculosis. At present, the situation of tuberculosis prevention and control is still very grim. According to the 2019 global tuberculosis report provided by the World Health Organization, there were about 10 million new tuberculosis patients in the world in 2018, and about 900,000 in China. It is estimated that there are about 484,000 new cases of rifampicin-res...
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