Sodium aescinate freeze-dried preparation for injection and preparation method of sodium aescinate freeze-dried preparation

A escin sodium, freeze-dried preparation technology, applied in the field of medicine, can solve the problems of irritation to the mucous membrane and respiratory tract, unfavorable to commercial production, troublesome research workers, etc., to achieve increased insoluble particles, good appearance, and shortened production The effect of the process step
CN112043674APending Publication Date: 2020-12-08FUJIAN MINDONG REJUVENATION PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUJIAN MINDONG REJUVENATION PHARMA
Publication Date
2020-12-08

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Abstract

The invention discloses a sodium aescinate freeze-dried preparation for injection and a preparation method of the sodium aescinate freeze-dried preparation, and belongs to the field of medicines. Thesodium aescinate freeze-dried preparation comprises and only contains sodium aescinate. The preparation method comprises the following steps: adjusting the pH value of a sodium aescinate solution, performing filtering with a micropore filtration membrane, performing filling, and performing freeze drying in three stages. The sodium aescinate freeze-dried preparation obtained by the method disclosedby the invention is good in appearance, good in redissolving effects, high in main drug purity, not easy to absorb moisture and stable in quality, and the drug purity and the medication safety are improved.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a freeze-dried preparation of sodium aescinate for injection and a preparation method thereof. Background technique

[0002] Sodium aescinate is the total saponin extracted from the dried mature seeds of Aescinaceae or Tianshi Chestnut. Various pharmacological studies have shown that sodium aescinate has the functions of anti-exudation, increasing venous tone, detumescence, anti-inflammation, anti-oxygen free radicals, promoting gastrointestinal motility and improving blood circulation. Clinically, it is widely used to treat cerebral edema, swelling caused by trauma or surgery, and it is also used to treat diseases such as venous reflux disorder, and has a good therapeutic effect.

[0003] Aescin is a general term for more than 30 kinds of saponins in the seeds of Aesculus aesculus. The study of its chemical composition began in the 19th century when it isolated saponin mixtu...

Claims

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