Application of AF-2364 in preparation of medicine for treating periprosthetic osteolysis
A technology of AF-2364, 1. AF-2364, applied in the field of new drug application, can solve the problems of insignificant therapeutic effect, no research, unsatisfactory therapeutic effect, etc., and achieve the effect of reducing degree, reducing osteolysis, and promoting expression
Active Publication Date: 2020-12-08
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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Problems solved by technology
However, there is no research on whether it can still play a positive regulatory role in the environment of accumulation of wear particles and inflammatory factors around the artificial prosthesis
Clinically, traditional osteoporosis drugs are not effective in the treatment of periprosthetic osteolysis
For example, bisphosphonates, calcitonin, although they can significantly inhibit osteoclast activation, have no significant therapeutic effect in periprosthetic osteolysis
Method used
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[0032] The present invention will be further described below in conjunction with specific examples, but the examples are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.
[0033] 1. Materials and methods
[0034] 1. Materials
[0035] 1.1 Reagents and experimental equipment
[0036] 1.1.1 Main Drugs and Reagents
[0037] AF-2364 (Adjudin), purchased from MCE, the U.S.; Ethylenediaminetetraacetic acid (EDTA), purchased from Sigma, the U.S.; Calcein (Calcein), purchased from Sigma, the U.S.; Paraformaldehyde; PBS; DAB chromogen ; hematoxylin; eosin; absolute ethanol; distilled water; 10% chloral hydrate; titanium parti...
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Abstract
The invention belongs to the technical field of new application of medicines, and discloses application of AF-2364 in preparation of a medicine for treating periprosthetic osteolysis. The periprosthetic osteolysis occurs after artificial joint replacement. Animal experiments prove that the AF-2364 can promote expression of pSer9-GSK-3[beta] and [beta]catenin and relieve osteolysis and bone loss induced by titanium particles, which indicates that the AF-2364 has a remarkable inhibition effect on the osteolysis induced by wear particles and can be used as a new means for drug intervention of periprosthetic osteolysis after the artificial prosthesis replacement.
Description
technical field [0001] The invention belongs to the technical field of new application of drugs, and specifically relates to the application of AF-2364 in the preparation of drugs for treating periprosthetic osteolysis. Background technique [0002] Total joint arthroplasty (TJA) is an effective means to treat various end-stage joint diseases. In my country, 1 million patients undergo joint replacement every year, and the trend is increasing year by year. However, with the increase in the number of joint replacements, the number of revisions due to prosthesis failure is increasing year by year. Taking knee joint revisions as an example, it is estimated that by 2030, the number of revisions will increase by more than 6 times. Aseptic loosening is the main cause of prosthetic failure. According to joint replacement data in England and Wales, revisions caused by aseptic loosening accounted for 52% of hip revisions and 41.2% of knee revisions. It can be seen that looseness has...
Claims
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IPC IPC(8): A61K31/416A61P19/08
CPCA61K31/416A61P19/08
Inventor 耿德春郑恺柏家祥李宁孙厚义张韦成徐耀增杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV