Medical cold compress dressing and preparation method thereof
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A skeleton material and growth factor technology, applied in dressings, viscous dressings, cooling appliances for treatment and treatment, etc., can solve the problems of unable to keep the wound moist, unable to promote wound healing, poor air permeability, etc. The effect of promoting skin absorption of nutrients and good film-forming properties
Active Publication Date: 2020-12-18
海南希睿达生物技术有限公司
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[0003] Traditional medical dressings are made of natural plant fibers or animal hairs, such as gauze, wool, cotton pads, oil gauze, etc., which have good water absorption, keep the wound dry, protect the wound, low cost, and a wide range of raw materials. Soft texture, easy to use, etc.; but this kind of dressing has disadvantages such as not waterproof, easy to pollute, easy to fall off, poor air permeability, unable to keep the wound moist, and unable to promote wound healing
Method used
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Embodiment 1
[0027] A medical cold compress dressing, which is composed of the following components: by mass percentage, seaweed polysaccharide 15%, sodium carboxymethylcellulose 5%, epidermal growth factor 0.002%, hyaluronic acid 7%, silk 5% gelatin, 8% silk fibroin, 3% grape skin extract, 6% carnation extract, 5% dance grass extract, 0.5% menthol, and the balance is water.
[0028] After the seaweed polysaccharide is washed with giant algae, centrifuge at 5000rpm for 3 minutes, remove the supernatant, add cellulase and papain to the sediment in turn for enzymolysis, heat to 100°C for 10min to inactivate the enzyme, and put it at 90°C Heating and extracting for 1h, cooling and then filtering and concentrating, the concentrated solution is obtained by ethanol precipitation.
[0029] The grape skin extract is obtained by washing the grape skins, adding water, and performing ultrasonic extraction with an ultrasonic power of 360W and an extraction time of 20 minutes, filtering, and concentrat...
Embodiment 2
[0039] The difference between embodiment 2 and embodiment 1 is:
[0040] The seaweed polysaccharide is obtained by crushing macroalgae, adding water and extracting in a water bath at 60°C for 8 hours, leaching three times, concentrating the extract, adding ethanol, standing in the refrigerator for 12 hours, centrifuging, collecting the precipitate, and freeze-drying.
Embodiment 3
[0042] The difference between embodiment 3 and embodiment 1 is:
[0043] The seaweed polysaccharides are mixed and washed with Songknits, Ascophyllum nodosum, and Fucus, then crushed, centrifuged at 8000pm for 3 minutes, removed the supernatant, added cellulase and papain to the sediment for enzymolysis, and heated to 100 After incubating at ℃ for 10 minutes to inactivate the enzyme, heat and extract at 80℃ for 2 hours, filter and concentrate after cooling, and the concentrated solution is obtained by ethanol precipitation.
[0044] The grape skin extract is a commercially available grape skin extract containing proanthocyanidins and polyphenols.
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Abstract
The invention discloses a medical cold compress dressing and a preparation method thereof. The medical cold compress dressing comprises the following components: algal polysaccharides, a hydrophilic gel skeleton material, growth factors, hyaluronic acid, sericin, silk fibroin, a grape skin extract, a Gypsophila paniculata extract, a Codariocalyx motorius extract, menthol and water. The preparationmethod of the cold compress dressing comprises the following steps: weighing the components according to the mass, mixing the components under a certain condition to obtain a hydrogel-like liquid, defoaming the hydrogel-like liquid, then pouring the defoamed hydrogel-like liquid into a mold, performing freeze molding to obtain a hydrogel film, performing vacuum sealing on the hydrogel film, and then performing sterilizing to obtain the medical cold compress dressing. The medical cold compress dressing provided by the invention can be used for cooling, repairing and nursing a skin barrier, promoting wound healing and protecting a wound, has the effects of replenishing water, resisting bacteria, diminishing inflammation, diminishing swelling and resisting oxidation, and also has good film-forming property, air permeability, moisture retention, biocompatibility and skin fitness.
Description
technical field [0001] The invention relates to the technical field of production of medical dressings in the technical field of medical care, in particular to a medical cold dressing and a preparation method thereof. Background technique [0002] The skin is an important barrier for the human body to resist external damage. In daily life, skin injuries are very common, such as skin abrasions, contusions, minor cuts, minor burns, sunburns, mild post-medical injuries and other superficial skin wounds caused by accidents or diseases, and damage to the skin barrier Afterwards, the resistance ability decreases, and it is easy to infect external bacteria, causing inflammatory reactions such as itching, redness, tingling, etc. When some skin barriers are damaged, there will be a small amount of bleeding and interstitial fluid leakage. Therefore, medical dressings are usually used in the repair and nursing of the skin barrier, which can play an important role in protecting the wou...
Claims
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