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Buffered microencapsulated compositions and methods

A microcapsule, polymer technology, applied in the directions of botanical equipment and methods, softening compositions, detergent compositions, etc., can solve the problems of unstable amorphous calcium phosphate, difficulty, etc.

Pending Publication Date: 2020-12-18
PREMIER DENTAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second technique (ENAMELON TM ) using unstable amorphous calcium phosphate
However, to date, adding these ingredients to these materials has been difficult or problematic due to stability reasons or degradation of the additive or the product itself

Method used

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  • Buffered microencapsulated compositions and methods
  • Buffered microencapsulated compositions and methods
  • Buffered microencapsulated compositions and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0227]A microcapsule composition of the invention comprising a buffered solution of a peptidyl antimicrobial agent was prepared. The composition is prepared by interfacial polymerization in a stable inverse emulsion of a peptidyl antimicrobial agent in phosphate buffered saline solution in a continuous phase of methyl benzoate. 6 grams of polyglyceryl-3-polyricinoleate (P3P) was used as emulsifier. The emulsifier and 4 grams of polyurethane polymer were mixed together. A buffered aqueous solution of the peptidyl antimicrobial (100 mL of 0.1 M) was added to 210 mL of the continuous methyl benzoate oil phase with mixing. Then 0.2 g of ethylene glycol was added to the inverse emulsion to complete the interfacial polymerization of the polyurethane polymer at the interface of the dispersed aqueous buffer solution of the peptidyl antimicrobial agent droplets. The average size of the microcapsules is controlled by the mixing rate. Using the method of the present invention, buffere...

Embodiment 2

[0229] A microcapsule composition of the invention comprising a buffered solution of a peptidyl antimicrobial agent was prepared. Compositions were prepared by interfacial polymerization in a stable inverse emulsion of phosphate buffered saline solution in a continuous phase of methyl benzoate. 6 grams of polyglyceryl-3-polyricinoleate (P3P) was used as emulsifier. The emulsifier and 4 grams of polyurethane polymer were mixed together and added to 210 mL of the continuous methyl benzoate oil phase with mixing. Then 0.2 g of ethylene glycol was added to the inverse emulsion to complete the interfacial polymerization of the polyurethane polymer at the interface of the dispersed buffered aqueous solution of the peptidyl antimicrobial agent. The microcapsules containing the buffered solution were stirred in a solution of the buffered peptide-based antimicrobial agent (0.1 M in 100 mL) while mixing and heated to 37°C, effectively encapsulating the antimicrobial agent into the micr...

Embodiment 3

[0231] The cavity varnish composition of the present invention having antimicrobial ability is prepared as follows. A standard cavity varnish containing rosin, ethanol and thymol (97 wt%) was mixed with 3 wt% microcapsules containing 0.1 M antimicrobial buffer in water.

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PUM

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Abstract

A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates theshell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.

Description

technical field [0001] This application is a continuation-in-part of divisional U.S. patent application 15 / 791,554, filed October 24, 2017, which is a divisional application of U.S. patent application 13 / 619,128, filed September 14, 2012 , which is a continuation-in-part of U.S. Application 12 / 768,696, filed April 27, 2010, which claims priority to U.S. Provisional Application 61 / 172,939, filed April 27, 2009, the entirety of which is adopted This reference is incorporated herein in its entirety. Background technique [0002] The present invention relates to compositions, compounds and methods for encapsulating buffered aqueous solutions within polymeric shells to form microcapsules, wherein the microcapsules are suitable for inclusion in carriers of commercial products. [0003] The microcapsules themselves are suitable for a variety of different uses, including oral or pharmacotherapeutic use of certain encapsulated compounds. For example, mineralized connective tissue i...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K33/16A61K33/44
CPCA61K45/00A61Q5/02A61Q11/00A61K8/11A61K2800/412A61K8/87A61K8/64A61Q5/10A61Q15/00A61K8/39C11D17/0039C11D3/001C11D1/62C11D3/48C11D3/505A01N25/28B01J13/14B01J13/185C09B67/0097A23P10/30A23L33/10A01N31/08A01N33/12A01N37/46
Inventor M·A·拉塔S·M·格罗斯W·A·麦克黑尔
Owner PREMIER DENTAL PRODS