Application of mucoprotein MUC1 to preparation of drug with lung aging delaying effect

A technology of mucin and medicine, applied in the field of genetic engineering, to alleviate or delay the effect of lung aging

Pending Publication Date: 2021-01-08
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether MUC1 has an effect on lung aging and how it works is still poorly understood

Method used

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  • Application of mucoprotein MUC1 to preparation of drug with lung aging delaying effect
  • Application of mucoprotein MUC1 to preparation of drug with lung aging delaying effect
  • Application of mucoprotein MUC1 to preparation of drug with lung aging delaying effect

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Embodiment Construction

[0034] The technical solution of the present invention will be described in detail below in conjunction with specific embodiments, so that those skilled in the art can better understand and implement the technical solution of the present invention. The reagents or materials used in the examples are all from commercial sources unless otherwise specified.

[0035] 1. Experimental animals and feeding

[0036] Experimental animals: 6-8 weeks old, weighing 20-22g, female, Balb / c wild-type mice (purchased from Guangdong Experimental Animal Center), Balb / c mice MUC1 (NCBI gene ID: 17829) gene knockout The mice were donated by Professor Mayor Clinic Sandy Gendler and bred in the Experimental Animal Center of Guangzhou Medical University.

[0037]Breeding environment: All experimental mice were raised in the SPF level experimental animal center of the First Affiliated Hospital of Guangzhou Medical University. Breeding conditions: well ventilated, room temperature between 20±5°C, humid...

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Abstract

The invention discloses application of mucoprotein MUC1 to preparation of a drug with a lung aging delaying effect. The drug with the lung aging delaying effect refers to a drug for promoting expression of mucoprotein MUC1 and enhancing MUC1 functions, and the lung aging delaying effect includes lung function decline inhibition and lung structure reconstruction. The invention further discloses a drug for delaying lung aging, and the active ingredient of the drug is the mucoprotein MUC1. The invention discovers a new function of a mucoprotein MUC1 gene, namely that the mucoprotein MUC1 gene hasthe function of inhibiting the lung aging process; and based on the effect of the mucoprotein MUC1 in inhibiting lung aging, the mucoprotein MUC1 can be used for preparing the drug for relieving or delaying the lung aging.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to the application of mucin MUC1 (Mucin 1) in the preparation of medicines with the effect of delaying lung aging. Background technique [0002] With the development of social economy and medical level, the life expectancy of human beings is gradually extended, and population aging has become a serious social problem in developed countries and some developing countries in the world. According to statistics, in 2010, the global population aged 65 and above was about 524 million, accounting for 8% of the total population, and it is expected to increase to nearly 1.5 billion by 2050, accounting for 16% of the total population. Among them, the population over the age of 65 in my country has gradually increased from 110 million in 2010, and is expected to reach 330 million by 2050. 92% of older adults had at least one chronic disease, and 77% had at least two chr...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K45/00A61K48/00A61K49/00A61P11/00
CPCA61K38/17A61K45/00A61K48/005A61K49/0008A61P11/00
Inventor 卢文菊刘菲王健徐静仪李媛媛陈灵珠
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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