The invention discloses a chronic disease management system and method. The management system comprises a collection module, a calculation module, a storage module, a data decision module and a wireless communication module, and the calculation module is connected with the collection module, the storage module, the data decision module and the wireless communication module separately. The management method comprises the steps that the collection module collects physiological indexes corresponding to chronic disease characteristics; the data decision module conducts data analysis on the physiological indexes to obtain a probability analysis result; the wireless communication module sends the probability analysis result through a wireless network, and peripheral equipment judges the state ofthe chronic disease according to the probability analysis result. According to the chronic disease management system and method, data collection and information decision mechanisms are applied to wireless network communication, under the mobile medical environment, data collection, decision and transmission are achieved, data early warning is achieved at a data terminal of a person with active ability, and the system and method well help old people to manage and control the chronic disease.