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Macro-encapsulated therapeutic cells, devices, and methods of using the same

A therapeutic and cell-based technology, applied in the direction of living prokaryotic cell medical raw materials, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of not allowing rapid systemic circulation of pancreatic hormones

Pending Publication Date: 2021-01-08
SERAXIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, subcutaneous implants are not expected to allow rapid systemic circulation of pancreatic hormones, resulting in periods of hyperglycemia

Method used

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  • Macro-encapsulated therapeutic cells, devices, and methods of using the same
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  • Macro-encapsulated therapeutic cells, devices, and methods of using the same

Examples

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example 1

[0140] Example 1 - Formation and testing of macroencapsulated cells

[0141] Sulfation of Cellulose: Cellulose was sulfated in a method similar to that used by Zhang et al., Cellulose, 17:427-435 (2010). Briefly, cellulose was suspended in anhydrous dimethylformamide (DMF) and slowly mixed with a solution of DMF / acetic anhydride / chlorosulfonic acid and stirred at 50°C for 5 hours. The mixture was then poured into a saturated solution of anhydrous sodium acetate in ethanol. The pellet was centrifuged and washed with 4% sodium acetate in ethanol. The precipitate was collected and mixed with 1M ethanolic sodium hydroxide at room temperature for 15 h. The pH was adjusted to 8 with a 50 / 50 mixture of acetic acid / ethanol. The precipitate was washed with ethanol and dissolved in deionized water. The solution was filtered through a 0.45 μm filter, dialyzed against deionized water, and lyophilized.

[0142] Sulfation of glucomannan: Suspend glucomannan in a solution of dimethylsul...

example 2

[0155] Example 2 - Treatment of Diabetes with Disclosed Encapsulated Cells

[0156] This example illustrates a method of treating type 1 diabetes in adults using macroencapsulated cells as described herein.

[0157] An adult subject with insulin-dependent diabetes mellitus undergoes a transplant comprising implanting a therapeutically effective amount of a composition comprising the disclosed macroencapsulated islet cells into the subject's omental pouch, anchored to omentum or peritoneal cavity. Assess the subject's blood glucose level. Following implantation of a therapeutically effective amount of macroencapsulated cells, the subject is monitored to ensure that the subject's blood glucose levels have stabilized. Subjects were further screened for HbA1c and comorbidities of diabetes over time.

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Abstract

Described are macro-capsules, barriers, and devices that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.

Description

[0001] related application [0002] This application claims priority under Title 35, United States Code, Section 119(e) of U.S. Provisional Application 62 / 637,085, filed March 1, 2018, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure relates generally to the field of cell transplantation and encapsulation of therapeutic cells. Macrocapsules for encapsulating therapeutic cells, processes for encapsulating therapeutic cells, and related methods for treating diseases such as diabetes are described. Background technique [0004] The following discussion is provided to assist the reader with an understanding of the present disclosure and is not intended to describe or constitute prior art to the present disclosure. [0005] diabetes and insulin [0006] Diabetes mellitus (ie, diabetes) is a disease in which the body's ability to produce or respond to the hormone insulin is impaired, leading to abnormal metabolism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/39A61L27/38A61L27/54A61K9/50A61K47/36A61K47/38A61P5/50A61P3/10
CPCA61K9/5036A61K35/39A61K2035/11A61L27/3804A61L27/54A61P5/48A61P5/50A61L31/08A61P3/10A61L31/04A61L27/56A61F2/022
Inventor W·L·鲁斯特
Owner SERAXIS
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