MiR-29 sponge, nucleic acid construct containing same and applications of miR-29 sponge

A technology of nucleic acid constructs and sponges, applied in the field of biomedicine, can solve problems such as application limitations, inability to meet the needs of metabolism, and individual differences in patients, so as to achieve the effects of improving survival rate, inhibiting secretion, and reducing the incidence of disease
CN112226436AActive Publication Date: 2021-01-15NANJING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING MEDICAL UNIV
Publication Date
2021-01-15

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Abstract

The invention discloses a miR-29 sponge, and further provides a nucleic acid construct containing the same. The invention finds that the miR-29 sponge can adsorb miR-29a-3p and miR-29b-3p in the body,close the functions of the miR-29a-3p and the miR-29b-3p and inhibit secretion of pro-inflammatory cytokines, so that insulitis of NOD mice is relieved, the serum insulin level is increased, the blood glucose tends to be normal, and finally, the onset of Type 1 diabetes mellitus (T1DM) of NOD (non-obese diabetic) mice is remarkably reduced, and the survival rate of the NOD mice is increased.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a miR-29 sponge inhibiting miR-29, a nucleic acid construct comprising the miR-29 sponge and its application in preparing medicines for treating or preventing type 1 diabetes. Background technique

[0002] Diabetes mellitus (DM) has become a common and frequently-occurring disease that seriously affects human health in modern society. According to the latest IDF report, as of 2019, approximately 463 million adults aged 20-79 worldwide suffer from diabetes. Although type 2 diabetes accounts for 90-95%, the prevalence of type 1 diabetes is also increasing at a rate of 2% to 5%, among which the incidence rate of children and adolescents under the age of 15 is the fastest growing. Although the incidence of type 1 diabetes is not as high as that of type 2 diabetes, it has a rapid onset, tends to be younger, and causes serious complications such as ketoacidosis and hyp...

Claims

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