Application of A-type ultrasonic waves to development of myopia-related drugs

An ultrasound and drug technology, applied in the application field of A-type ultrasound in the development of myopia-related drugs, can solve the problems of complicated and time-consuming process, high technical difficulty, high experimental cost, and achieve no damage to the whole body, good repeatability, and high technology. stable effect

Pending Publication Date: 2021-01-22
JOINN LAB (SUZHOU) INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The threshold of the required experimental conditions is high, the equipment is complex, the process is complicated and time-consuming, the technical difficulty is high, and the experimental cost is high. What is more important is that this kind of experiment only obtains the data of isolated tissues, and there is still a big difference between the simulated culture environment and the living environment. distance, it is difficult to accurately reflect the actual situation in the body

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  • Application of A-type ultrasonic waves to development of myopia-related drugs
  • Application of A-type ultrasonic waves to development of myopia-related drugs
  • Application of A-type ultrasonic waves to development of myopia-related drugs

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Experimental program
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Embodiment 1

[0042] 1. Experimental materials and methods:

[0043] Experimental animals: 12 healthy juvenile cynomolgus monkeys with normal eyes were selected, aged 45.9 months ± 2.4 months (equivalent to the age of puberty in humans), mean ± standard deviation (the same below), weight 3.8 ± 0.6 kg, male and female half and half.

[0044] Drugs to be tested: 1.0% atropine sulfate eye drops (Day Point, Nagoya) and 0.5%, 0.1%, 0.05% and 0.01% atropine eye drops diluted with neutral phosphate buffer.

[0045] Control substance: neutral phosphate buffer solution (PBS, pH=7.4).

[0046] Administration method: a single topical eye drop, 30 μl per eye, administered to both eyes at the same time.

[0047] Testing instrument: ophthalmology A / B type ultrasonic diagnostic instrument (ODM-2100S, Tianjin Maida Medical Technology)

[0048] ODM-2100S ophthalmology type A eye axis biological parameter measurement part technical indicators:

[0049] Ultrasonic frequency 10MHz

[0050] Measurement accu...

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Abstract

The invention discloses a method for measuring the thickness change of the crystalline lens of a non-human primate (monkey) through an A-type ultrasonic technology and verifying the relaxation effectof an M receptor antagonist on ciliary body smooth muscle. The method can be used for measuring the influence of test drugs with different concentrations on the thickness of the crystalline lens, knowing the dose-effect relationship between the test drugs and the thickness of the crystalline lens, speculating the influence of the drugs on refractive adjustment, detecting the effective dose and quickly and effectively guiding the preclinical research and development work of new drugs for preventing and treating juvenile myopia. The method disclosed by the invention is simple, stable in technology, good in repeatability, free of tissue trauma to animals and harmless to the health of the whole body. Experimental data obtained from monkeys (animals closest to human beings) has incomparable guiding significance to other animals in clinical tests, so that important transformation medical information is provided for research and development of innovative drugs.

Description

technical field [0001] The invention relates to the field of research and development of biomedicine, in particular to the application of A-type ultrasonic waves in the development of medicines related to myopia. [0002] technical background [0003] Juvenile myopia is a common eye disease in my country. Due to the pressure of entering a higher school and environmental factors such as the popularization of computers, the prevalence rate is increasing year by year, which is an important issue affecting the health of adolescents. How to effectively prevent and treat myopia and protect the eyesight of young people is a major issue that needs to be solved urgently. [0004] In addition to genetic factors, the main factors causing myopia in adolescents include heavy learning tasks, insufficient lighting or visual fatigue caused by close-up writing and reading for a long time. The eyeballs of teenagers are in the stage of growth and development. The adjustment ability of vision ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61B8/10
CPCA61K49/0008A61B8/10A61B2503/40A61B2503/42
Inventor 李和平廖琴蔡可阳
Owner JOINN LAB (SUZHOU) INC
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