36 results about "Ciliary epithelium" patented technology

The invention discloses an application of NRP1 in prevention and treatment of acute anterior uveitis. Researches find that expression deletion of the NRP1 promotes polarization of macrophages to M1, expression of the NRP1 in an iris-ciliary body compound of an acute anterior uveitis model mouse is reduced, an inhibitor of the NRP1 promotes the inflammation phenotype of the acute anterior uveitis model mouse, the NRP1 protein inhibits the phenotype of the acute anterior uveitis model mouse, and the NRP1 protein inhibits the inflammation phenotype of the acute anterior uveitis model mouse. The expression deletion of the NRP1 in the macrophages aggravates the inflammation phenotype of an acute anterior uveitis model mouse, so that the NRP1 can be used for preventing and / or treating the acute anterior uveitis and has a very good application prospect.

The invention discloses a single-incision one-step method TICL implantation method based on a 3D navigation system, and relates to the technical field of medical device.The single-incision one-step method TICL implantation method comprises the steps of S1, data collection, S2, three-dimensional modeling, S3, incision path planning, S4, operation implementation, S5, single-incision TICL implantation and S6, postoperative evaluation.Ocular optical data of a patient is collected through ophthalmology imaging equipment, the three-dimensional modeling, the incision path planning, the operation implementation, the single-incision TICL implantation and the post-operation evaluation are carried out, and the three-dimensional modeling, the three-dimensional modeling, the incision path planning, the operation implementation, the An individualized eye structure model is constructed in combination with a three-dimensional modeling technology, accurate fusion of astigmatism axial direction and cornea morphological parameters is realized, an incision path is planned by using a dynamic optimization algorithm and a genetic algorithm, key anatomical structures such as an iris root and a ciliary body are avoided while the incision length is minimized, operation wounds are reduced, and the operation efficiency is improved. The astigmatism correction angle is automatically optimized through a weighted average formula, manual errors are effectively reduced, and it is ensured that operation planning better fits anatomical features of a patient.

The invention provides an ophthalmology minimally invasive drainage device with an expansion fixing function and a delivery system thereof, the ophthalmology minimally invasive drainage device comprises a drainage main body with a hollow cavity and an expansion fixing device, and the drainage main body comprises a near-end part and a far-end part far away from the near-end part; the expansion fixator is in a two-dimensional plane shape or a three-dimensional shape and is provided with a first end and a second end, the first end is connected with the near end part of the drainage main body, and the second end is connected with the far end part of the drainage main body; the near end part is one end close to the suprachoroidal space and has the length of 0.2-2.5 mm, and the far end part is one end close to the anterior chamber of the eye and has the length of 0.5-3.0 mm. According to the ophthalmology department minimally invasive drainage apparatus with the expansion and fixing functions, the drainage body with the hollow cavity is adopted, and the loading and implanting requirements can be met; after being released, the dilation fixer recovers to a preset shape, so that the dilation fixer can play a role in enhancing the intraocular fixing effect while playing a drainage role, ciliary body dissociation is formed, and then the effects of promoting aqueous humor absorption and inhibiting aqueous humor secretion are achieved.

The present disclosure describes an optical probe for applying a laser light to at least the flat portion of the ciliary body and optionally other areas, such as the trabecular mesh, the ciliary crown and / or the ciliary sulcus of the eye, the present invention relates to methods, such as for treating glaucoma, reducing intraocular pressure (IOP), improving the outflow of aqueous humor from the eye, and / or reducing the accumulation of aqueous humor within the eye. The optical probe may be adapted for simultaneous treatment of a plurality of different regions, tissues, or eye bodies of the eye, or for sequential treatment of a plurality of different regions, tissues, or eye bodies of the eye.

The utility model provides eye treatment equipment, which relates to the technical field of ophthalmology medical treatment, and comprises a control host, a treatment device, a control pedal and a negative pressure positioning device, the treatment device, the control pedal and the negative pressure positioning device are respectively connected to the control host; the negative pressure positioning device is provided with a negative pressure ring matched with the eyeball, the negative pressure ring is attached to and adsorbed to the eyeball, the treatment device sends out high-strength ultrasonic waves to act on target tissue, the eyeball can be accurately positioned, ciliary body coagulation treatment is carried out, and the adaptability of the eye treatment equipment to a patient and the operation convenience are improved.

1. The name of the design product: ciliary body puncture forceps. 2. The use of the design product: used for marking the ciliary body puncture position and fixing the eyeball in the eye operation. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: front view.

An ab externo automated laser treatment system for treating an eye in a subject, includes a non-contact laser source configured to generate a laser beam having at least one wavelength to treat the eye by directing the laser beam from a location spaced from the eye, wherein the at least one wavelength is a near-infrared wavelength in the range of about 0.5-2.2 μm, a laser scanner optically coupled to the non-contact laser source to receive the laser beam from the non-contact laser source and to scan the laser beam relative to the eye, and a processor, and memory including stored computer-readable instructions that, responsive to execution by the processor, cause the laser treatment system to direct the laser beam to a plurality of trans-scleral treatment locations to be irradiated in a predetermined treatment pattern on an external surface of the eye, wherein the trans-scleral treatment locations are 0-4 mm posterior to the corneolimbal junction, and wherein the laser beam is repetitively directed to the same irradiated trans-scleral treatment locations on the surface of the eye, and the trans-scleral treatment locations are irradiated at intervals sufficient to induce protective thermal preconditioning and therapeutic bio-stimulation of one or more of the trabecular meshwork and / or ciliary body without photocoagulation of the tissue of the eye. Trans-pupillary systems, patient interfaces, and methods are also disclosed.

The utility model discloses a micropulse ciliary body photocoagulation assist device which comprises an auxiliary handle, an eyeball fixing ring is connected to the end of the auxiliary handle, fixing sawteeth used for assisting in fixing an eyeball are evenly distributed at the bottom end of the eyeball fixing ring, and the end of each fixing sawtooth is arranged to be an arc-shaped end. The outer surface of the eyeball fixing ring is fixedly connected with a probe auxiliary device used in cooperation with the micro-pulse probe, and the probe auxiliary device is arranged on the side portion of the auxiliary handle. The eyeball fixing ring is arranged at the corneal limbus of the surface of an eyeball, the fixing sawteeth make contact with the ocular surface and are slightly pressed to fix the eyeball, the micro-pulse probe penetrates through the probe auxiliary device to extend to the ocular surface, and the ciliary body photocoagulation operation is started to be carried out, and in the operation, the probe auxiliary device supports the micro-pulse probe and limits the moving route of the micro-pulse probe. Therefore, the ocular surface marking of the ciliary body photocoagulation does not need to be specially carried out, the operation time is shortened, and the probe control precision and the use safety are improved.

The invention discloses a radiofrequency ablation puncture system for a ciliary body. The radiofrequency ablation puncture system comprises a handle; the needle core comprises a body part and a tip part, the body part is fixed in the handle part, and the tip part is located at the first end of the body part and extends out of the handle part; the tip part comprises a first section and a second section, the first end of the first section is connected with the body part, the second end of the first section is connected with the second end of the second section, and the first end of the second section is arranged to be a puncture tip; the first section is bent relative to the second section, and the orthographic projection of the handle part and the orthographic projection of the second section do not have a coincident part; the insulation sleeve is connected to the first section and the second section in a sleeving mode, the puncture tip extends out of the insulation sleeve, and at least one part of the insulation sleeve is arranged to enter the puncture channel along with the puncture tip. The technical effect that when the handle part is held for surgical operation, the guiding equipment can accurately guide from the position over the second section and does not interfere with the action of the handle part is achieved.

The application discloses a teaching simulative human eyeball aqueous humor circulation model in the technical field of eyeball aqueous humor circulation models, which comprises a model box, an eyeball model assembly arranged in the model box, a functional body arranged at the top of the model box and a pump assembly arranged in the functional body. The eyeball model assembly comprises an eyeball wall, an eyeball and an optic nerve, and the eyeball wall is provided with a cornea at the front end. An iris is arranged on the side of the cornea close to the eyeball, the space between the cornea and the iris is an anterior chamber, the included angle between the cornea and the iris is an anterior chamber angle, the center of the iris is provided with a pupil, the iris is provided with a lens on the side close to the eyeball, the lens is provided with a zonular ligament around the lens, and the other end of the zonular ligament is fixedly connected with a ciliary body. The space between the iris and the lens constitutes a posterior chamber. The application has the advantages of simple structure, simulation of the process that the aqueous humor is retained in the eye to press the optic nerve when the anterior chamber angle is closed or the aqueous humor outflow passage is blocked, and convenience for medical students to understand the process that the optic nerve is pressed by the increased intraocular pressure when the aqueous humor passage is blocked.

An apparatus for implant into an eye. The apparatus may comprise a receptacle configured to receive an optic; a flange circumscribing the receptacle, the flange configured to be disposed in the ciliary sulcus of the eye; and a fenestration through the flange, the fenestration configured to allow aqueous humor to pass anteriorly from the ciliary body to the trabecular meshwork of the eye. Some or all of the apparatus may have an oleophobic coating. For example, some embodiments of the flange may have an oleophobic coating. In some embodiments, the fenestration may be inferior to the receptacle. Additionally, or alternatively, the apparatus may further comprise at least two haptics coupled to the flange.

The present invention discloses an intraocular pressure elevation teaching device, which includes a main cavity, a simulated vitreous body, a simulated lens, a simulated iris, a simulated ciliary body, a first injection tube, and an indicating cavity. The simulated vitreous body is arranged in the main cavity, the simulated lens and the simulated ciliary body are arranged on the front side of the simulated vitreous body, the simulated iris is arranged on the front side of the simulated lens and the simulated ciliary body and is connected to the simulated ciliary body, and a posterior chamber is formed between the simulated iris and the simulated lens. The simulated iris includes a first simulated iris, the inner side of the first simulated iris for forming the pupil is hermetically connected to the simulated lens, and the first posterior chamber formed between the first simulated iris and the simulated lens is not communicated with other parts of the posterior chamber; the first posterior chamber is communicated with the main cavity, a first injection tube communicated with the first posterior chamber is arranged in the simulated ciliary body of the first posterior chamber, and an indicating cavity communicated with the main cavity is arranged on the simulated vitreous body. Using this intraocular pressure elevation teaching device can simulate and demonstrate the principle of intraocular pressure elevation.

Example embodiments relate to a computer-implemented method for generating an opto-mechanical model of a camera-type eye from ocular biometry parameters that define the anatomy of the camera-type eye; wherein the ocular biometry parameters comprise at least a pupil size (224) and an iris thickness (223). The computer- implemented method comprises obtaining a predetermined iris shape (220) and a predetermined ciliary body shape (230); anchoring (201) one or more data points (221) of an outer edge of the iris shape (220) to one or more reference points of the posterior corneal surface; transforming (202) the iris shape (220) as to respect the pupil size (224) and the iris thickness (223); anchoring (203) a first portion of the outer edge (250) of the ciliary body shape to a portion of an outer edge (225) of the iris shape; transforming (204) the ciliary body shape (230) such that a second portion of an outer edge (231) of the ciliary body shape coincides with a portion of the inner scleral surface (212); and generating (205) one or more polygons (261, 262) indicative for respective zonular fibres, wherein the respective one or more polygons are defined by at least two data points located on the crystalline lens surface (240) and at least two data points located on an inner edge (232) of the ciliary body shape.

An ophthalmic assembly includes a frame, a flange, and a light emitter. The frame supports the optical lens. A first end of the flange is connected to the frame. The second end of the flange rests on a ciliary body flat region of the sclera of the patient's eye. A light emitter is connected to the flange proximate the second end to direct light into a vitreous cavity of the patient's eye. Light passes through the sclera at the flat region of the ciliary body, uniformly illuminating the vitreous body. A transscleral illumination system includes the ophthalmic assembly and a processor in communication with the light emitter. The setting of the light emitter may be controlled via a processor, for example in response to a user input signal.

The invention provides a method for extracting and pulling a crystalline lens, which comprises the following steps of: removing redundant connective tissues around, and making a transverse incision in the equator part of an eyeball; the eyeball at the upper half part is lifted outwards together with the vitreous body, and the connected sclera is cut off; the upper half part of the eyeball is placed on the supporting device, and the eyeball wall is embedded between the sclera fixing inner ring and the sclera fixing outer ring; cutting off the whole cornea; the ciliary body and the choroid are retained; the glue is coated on the round hole of the transfer device; the transfer device is adhered to the ciliary body and the choroid, and iris tissue is cut off; cutting off the sclera fixing inner ring and the sclera fixing outer ring; putting the transfer device and the adhered crystalline lens into a traction device; the traction line penetrates out of the traction cover plate; the traction line is tied to a traction hook at the top end of the traction device, the spiral of the traction device is rotated, the traction line is tensioned upwards, and the crystalline lens is driven to be pulled. The traction device is more uniform in traction, simple in structure, low in manufacturing cost, small in size and more suitable for being built in a laboratory.

The present invention discloses a radiofrequency ablation handle, comprising a shell and a radiofrequency ablation electrode installed in the shell, the front end of the radiofrequency ablation electrode extending out of the shell; the radiofrequency ablation electrode is cylindrical as a whole, comprising an electrode positive pole located in the center, an insulating sleeve arranged on the periphery of the electrode positive pole, and an electrode negative pole arranged on the periphery of the insulating sleeve; the electrode positive pole, the insulating sleeve, and the electrode negative pole are coaxial, and the electrode positive pole and the electrode negative pole can slide relative to each other. After the radiofrequency ablation electrode is energized, an ablation zone is generated between the electrode positive pole and the electrode negative pole, and the ablation zone is used to act on the ciliary body to reduce the production of aqueous humor; the shell is also connected to a pushing mechanism, and the pushing mechanism is used to adjust the distance between the front end of the electrode positive pole and the front end of the electrode negative pole. In the present invention, the pushing mechanism accurately adjusts the depth of the radiofrequency ablation electrode inserted into the eye to adapt to the eyeballs of different patients and achieve the purpose of precise ablation. The present invention also provides a radiofrequency ablation device that is easy to operate and use.

The utility model discloses a suture permanent lens capsular bag drag hook. The drag hook comprises a traction element, wherein the traction element is composed of a pull plate and a hanging plate formed by returning and bending one end of the pull plate; a notch is formed in the position, corresponding to the hanging plate, of the pulling plate, and the hanging plate gradually gets close to the hanging plate from the connecting position of the hanging plate and the pulling plate, enters the notch formed by the hanging plate and then is bent reversely to be gradually away from the pulling plate upwards from the notch. The suture is arranged at the other end of the pulling plate; and the puncture needle is connected to the tail end of the suture. During an operation, a needle head penetrates through a main incision, the needle head is led out from a dislocation position of a suspended ligament of a crystalline lens and a flat part of a ciliary body, a traction element is fixed on the suspended ligament at the dislocation position, the effect of outwards lifting and stabilizing a capsular bag is achieved, stretching force is adjusted through a suture, and finally the suture is knotted and fixed on a sclera surface.

The utility model discloses a novel vitreous cavity injector capable of being positioned, which comprises a guiding and positioning mechanism and an injector, the guiding and positioning mechanism comprises an outer cylinder and a positioning ring, the positioning ring is arranged at the front end of the outer cylinder, the positioning ring and the outer cylinder are of an integrated structure which is concentrically arranged, and a concentric annular silica gel gasket is arranged on the front end face of the positioning ring. The silica gel gasket is positioned on the flat part of the ciliary body behind the cornea sclera edge of the eyeball of the patient; and a metal needle catheter is arranged in the center of the front end surface of the outer cylinder. The silica gel gasket of the positioning ring at the front end of the outer cylinder is tightly attached to the cornea sclera edge and makes flexible contact with the eyeball, and the needle head can be directly positioned on the flat portion of the ciliary body of a patient; after the needle head is inserted into the eyeball of a patient, the positioning ring at the front end of the outer cylinder provides certain supporting force, so that unnecessary damage to the eyeball of the patient caused by shaking of the hand, slippage of the needle head and the like during medicine injection is prevented; the positioning ring is suitable for the outer diameter radians of various eyeballs, and can accurately position a 4 mm injection point behind the corneal limbus.

The present invention discloses a radiofrequency ablation handle, comprising a shell and a radiofrequency ablation electrode installed in the shell, wherein the front end of the radiofrequency ablation electrode extends out of the shell; the radiofrequency ablation electrode is cylindrical as a whole, comprising an electrode positive pole, an insulating sleeve and an electrode negative pole; after the radiofrequency ablation electrode is energized, an ablation band is generated between the electrode positive pole and the electrode negative pole, and the ablation band is used to act on the ciliary body to reduce the production of aqueous humor; the shell is also connected to a pushing mechanism, which is fixedly connected to the electrode positive pole, and the electrode negative pole is fixedly connected to the shell, and the pushing mechanism can drive the electrode positive pole to move back and forth, and adjust the distance between the front end of the electrode positive pole and the front end of the electrode negative pole. In the present invention, the pushing mechanism accurately adjusts the depth of the radiofrequency ablation electrode inserted into the eye to adapt to the eyeballs of different patients and achieve the purpose of precise ablation. The present invention also provides a radiofrequency ablation device, which is easy to operate and use.

The present invention relates to compounds for treatment of a disease or disorder associated with excessive vascularisation of the eye, such as for instance corneal neovascularisation, neovascularisation of the iris, neovascularisation of the ciliary body, corneal pannus, choroidal neovascularisation, retinal neovascularisation, wet age-related macular degeneration, proliferative diabetic retinopathy, retinopathy of prematurity, and ischemic retinopathy.

The utility model belongs to the field of biomedical models, and provides a device for simulating adjustment of a ciliary body to a crystalline lens, which comprises a driving component for providing power drive, a ciliary body model component for simulating the function of the ciliary body and a crystalline lens model component for simulating the function of the crystalline lens, the driving assembly comprises a positioning disc arranged on the outer side of the crystalline lens model component in a sleeving mode, the ciliary body model component comprises a plurality of ciliary processes which are arranged on the outer side of the crystalline lens model component in a surrounding mode and can move in the radial direction of the positioning disc, and a plurality of small ciliary belts are arranged between the ciliary processes and the crystalline lens model component; the driving assembly, the ciliary body model component, the crystalline lens model component and the ciliary ribbons are used in cooperation, it is guaranteed that a plurality of ciliary processes can move synchronously through the synchronous structure, the working process of the ciliary body in the physiological state is highly restored, the simulation degree of the model is remarkably improved, and the simulation degree of the ciliary body model is improved. And a more real and accurate simulation effect is provided for teaching.

The application discloses sgRNA targeting carbonic anhydrase 2 and application thereof. The sgRNA targeting carbonic anhydrase 2 comprises sgRNA as shown in SEQ ID NO. 1 and sgRNA as shown in SEQ ID NO. 2. The application develops sgRNA for double-site knockout of ciliary body Car2 based on CRISPR-Cas9 and AAV technology, realizes efficient Car2 targeting, has high knockout efficiency, effectively inhibits aqueous humor production, has obvious effect of reducing intraocular pressure and long maintenance time, significantly reduces retinal ganglion cell apoptosis, can be used for glaucoma treatment, and has wide application prospect.

The present disclosure relates to a drug for preventing and / or treating glaucoma. Specifically, provided in the present disclosure is the use of an adenosine A2A receptor antagonist in the treatment and prevention of glaucoma. The treatment and prevention include, but are not limited to, inhibiting aqueous humor production in non-pigmented epithelial cells of the ciliary body, reducing elevated intraocular pressure caused by the obstruction of aqueous humor outflow due to fibrosis and thickening of the trabecular meshwork, improving the fluidity of aqueous humor in the eye, inhibiting pathological changes in the trabecular meshwork, and achieving a protective effect on retinal cells. Additionally, the drug of the present disclosure may also help to reduce the problem of drug tolerance in the treatment of glaucoma, can lower intraocular pressure in glaucoma patients and provide a protective effect on optic nerves, and provides a more effective strategy for long-term treatment.

The invention discloses an eyeball model for simulating glaucoma surgery, which comprises an eye model base body and a plurality of detachable modules, and is characterized in that the eye model base body and one or more detachable modules are spliced to form a complete eyeball model; the eyeball model comprises a cornea, a sclera, an iris and a ciliary body, the cornea and the sclera are located on the outer layer, and the iris and the ciliary body are located on the inner layer; the outer wall of the detachable module is located at the junction of the sclera and the cornea and extends into the eyeball model; the detachable modules are further provided with trabecular meshes at the junctions of the cornea and the irises, the trabecular meshes are in any one of the states of chamber corner opening, chamber corner closing, incision, excision, glaucoma drainage device implantation and drainage tube implantation, and the states of the trabecular meshes in different detachable modules are different. According to the eyeball model for the glaucoma surgery provided by the invention, various glaucoma surgery principles and processes are intuitively displayed, and the eyeball model has special characteristics and is intuitively and pertinently displayed, so that patients and family members are helped to better understand surgery modes and principles, thereby better cooperating with treatment.

A lens device for treatment of an eye having a lens capsule with an internal chamber bound, in part, by a dynamic anterior optic and having a perimeter region. A deformable region having a three-dimensional bellows shape defining a volume projects radially outward from the perimeter region of the lens capsule and has an outer membrane segment configured to bend around a hinge relative to an inner membrane segment. A volume of an optical liquid is contained within the internal chamber and the volume of the deformable region. A force translation arm extends radially outward from the deformable region. Upon implantation of the lens device, the force translation arm directly contacts ciliary tissue to harness ciliary body movements that compresses and reduces the volume of the deformable region displacing optical liquid contained within the volume of the deformable region towards the internal chamber.

The invention relates to a cortex-ciliary body neural pathway remodeling system, and belongs to the technical field of optic nerve regulation and control. The system comprises a visual state perception module, a remodeling strategy generation module, a neural pathway collaborative stimulation module and a closed-loop evaluation optimization module. The method comprises the following steps: generating a dynamic evaluation report including a visual adjustment index by acquiring visual-physiological multi-modal data of a user; analyzing the eye regulation function state based on an AI biofeedback algorithm, and generating a personalized training scheme and matched stimulation parameters; synchronously outputting visual and physical stimulation according to a preset time sequence, and constructing a bidirectional closed-loop regulation and control path from the cerebral cortex to the eye effector; and quantitatively analyzing index differences through multi-source feedback, iteratively updating training parameters, and forming a path remodeling iteration regulation and control mechanism. According to the invention, a cortex-ciliary body neural pathway remodeling function is realized, and a visual regulation function is effectively improved.

The present invention provides an ophthalmic minimally invasive drainage device with an expansion and fixation function and a delivery system thereof, wherein the ophthalmic minimally invasive drainage device comprises a drainage body with a hollow cavity and an expansion fixator, wherein the drainage body comprises a proximal portion and a distal portion away from the proximal portion; the expansion fixator is in a two-dimensional plane or a three-dimensional solid shape and has a first end and a second end, the first end being connected to the proximal portion of the drainage body, and the second end being connected to the distal portion of the drainage body; the proximal portion is an end close to the suprachoroidal space, and its length is 0.2-2.5 mm, and the distal portion is an end close to the anterior chamber of the eye, and its length is 0.5-3.0 mm. The ophthalmic minimally invasive drainage device with an expansion and fixation function of the present invention adopts a drainage body with a hollow cavity, which can meet the requirements of loading and implantation; after being released, it returns to a preset shape. While playing a drainage role, the expansion fixator can enhance the fixation effect in the eye, form ciliary body dissociation, and thereby promote aqueous humor absorption and inhibit aqueous humor secretion.

This invention relates to the field of optical detection, specifically to a universal method and device for detecting the focal length of a human eye based on the ciliary body. The method includes: obtaining the focal length of a sample group at different standard focal lengths f1 to f2. m The OCT light signal set of the ciliary body region was collected, and each different site M1 to M2 was extracted from the OCT light signal set. n Points P1 to P2 in different layers i The sample light reflectance coefficients, after normalization transformation, are used to obtain different standard focal lengths f1 to f2. m The invention obtains the "feature point-sample mean light reflectance coefficient curve" and the "feature point-measured light reflectance coefficient curve" for any focal length of the subject, and fits it with the "feature point-sample mean light reflectance coefficient curve" to obtain the measured focal length value of the subject. This invention achieves universal detection of the human eye's actual focal length based on the ciliary body, avoiding eye discomfort caused by laser irradiation of the lens, allowing the subject to enjoy a better testing experience with less eye stimulation, and further making focal length detection more accurate.

The invention relates to an additional intraocular lens (1) of the posterior chamber type configured to be implanted in a pseudo-lenticular eye (9) and comprising: a central optical site (2); a peripheral haptic site (3) having a distal support element (4) arranged to support the intraocular lens (1) on the ciliary leucorrhea; elongated flexible pads (5) mounted on the support element (4), each having a distal lateral boundary (53) arranged to stabilize the intraocular lens (1) in the ciliary body (98); and manipulation pockets (6) located on the surface of the support element (4), each manipulation pocket being associated with one of the elongate flexible pads (5).

Methods for the ophthalmic delivery of roflumilast. The inventors have made the surprising discovery that the administration of pharmaceutical compositions comprising roflumilast to the cornea preferentially delivers the drug laterally through the ocular surface and anterior tissues of the eye. In contrast to the delivery of roflumilast to the skin, which primarily travels transversely through the various tissues of the skin, or many other topical ocular pharmaceutical compositions which travel through the cornea to the aqueous humor, the delivery of drug to the eye to the cornea travels laterally to the ocular surface and anterior tissues of the eye. Such methods can result in elevated levels of the drug in the cornea and other ocular surface and anterior tissues of the eye (e.g., iris-ciliary body, sclera, conjunctiva, and aqueous humor) relative to the interior or posterior tissues of the eye.