36 results about "Ciliary epithelium" patented technology

A device is disclosed for the localized irradiation of the whole or a large part of the ciliary body of an eye. The device includes one or more optical sources and a system for the delivery of a complete or partially annular distribution of radiation to the eye.

An accommodating intraocular lens (AIOL) including a biasing mechanism for elastically deforming an elastically deformable shape memory disk-like optical element for affording the AIOL a natural positive diopter strength for near vision. The AIOL is intended to be implanted in a human eye such that relaxation of its ciliary body causes its capsular diaphragm to apply an accommodation force for overcoming the biasing mechanism to reduce the AIOL's natural positive diopter strength for distance vision.

Laser and non-laser means to remove a portion of the ciliary body tissue for the treatment of presbyopia and glaucoma are disclosed. Mechanisms based on elasticity increase the sclera-ciliary-body and zonule “complex” is proposed. Total accommodation based a lens relaxation and lanes anterior shift is calculated. The preferred embodiments for the ablation patterns include radial lines, curved lines, ring dots or any non-specific shapes in a symmetric geometry. The surgery apparatus includes lasers in UV (0.19 to 0.35 micron) and IR (2.8 to 3.2) micron, and non-laser device of radio frequency wave, electrode device, bipolar device and plasma-assisted device. Post-operation medication such as pilocarpine (0.5%-5%) or medicines with similar to reduce postoperative regression or enhance the accommodation is presented. A much deeper, about (0.8-1.4) mm, ablation depth supraciliary body is proposed for (50%/-200%) greater accommodation than the prior arts based on superficial scleral ablation or expansion.

A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.

The invention comprises a device for treating presbyopia. A stretch segment is provided for intraocular implantation into the annular sulcus region defined by the intersection of the iris and ciliary body. The stretch segment engages and exerts an outward radial tension against the ciliary body. The segment is designed to take up slack in the equatorial zonules in the presbyopic eye, such that their effective working distance is enhanced. This aids in the accommodation process which affects the curvature of the lens for near viewing. The segment may a closed ring, or may be open ended.

Presbyopia and other eye disorders are treated by implanting within a plurality of elongated pockets formed in the tissue of the sclera of the eye transverse to a meridian of the eye, a prosthesis having an elongated base member having an inward surface adapted to be placed against the inward wall of the pocket and having a ridge on the inward surface of the base extending along at least a major portion of the major dimension of the base. The combined effect of the implanted prostheses is to exert a radially outward traction on the sclera in the region overlying the ciliary body which expands the sclera in the affected region together with the underlying ciliary body. The expansion of the ciliary body restores the effective working distance of the ciliary muscle in the presbyopic eye and thereby increases the amplitude of accommodation. Introduced is an improved scleral prosthesis for the treatment of presbyopia and other eye disorders. An exemplary prosthesis is adapted for contact with the sclera of an eyeball, and comprises a body having a first end and a second end wherein the body has (i) a planform adapted to expand the contacted sclera to increase the effective working distance of the ciliary muscle of the eyeball, and (ii) means for stabilizing the prosthesis within the surgically formed pocket within the sclera of the eyeball.

The invention relates to a physical teaching aid, and particularly relates to a variable-focus water lens which comprises an orbit (namely a round lens frame), a crystalline lens (namely an elastic transparent film and water), a ciliary body (comprising a plastic straw, a valve core and an injector) and a metal rod. The variable-focus water lens is characterized in that the elastic transparent film is sheathed on the round lens frame for sealing so as to form a sealing cavity capable of containing the water; the bottom end of the round lens frame is connected with the metal rod; a small hole at the top end of the round lens frame is connected with the plastic straw; the part, extending out of the round lens frame, of the plastic straw is connected with the valve core; the other end of the valve core is connected with the injector; and the injector is used for injecting water into the elastic transparent film or sucking the water in the elastic transparent film, so that the convex degree of the elastic transparent film is changed, and then the focus of the water lens can continuously change according to experimental demands. The variable-focus water lens is simple and convenient in material selection, can show clear phenomena and vivid images, and is simple to operate and strong in practicability.

The present invention relates to a folding type artificial vitreous body. The folding type artificial vitreous body comprises a balloon, a drainage tube and a drainage valve, one end of the drainage tube communicates with the balloon, the other end of the drainage tube is connected with the drainage valve, after the balloon is filled with filling medium by the drainage valve and the drainage tube,shapes of the balloon are adapted to a portion implanting into eyeballs, wherein one side of the balloon facing eye lens is an optical zone, the optical zone is plane, and a diameter of the optical zone is 9-25 mm. The optical zone of the balloon is designed to be plane to avoid affecting physiological functions of a ciliary body. In addition, the plane optical zone does not cause refraction andeffectively reduces situation where operators produce judgment errors on amount of the injected liquid medium due to refraction in conventional folding type artificial vitreous body.

The invention relates to materials and methods for the modulation of intraocular and intracranial pressure, and treatment of associated conditions such as glaucoma and hydrocephalus. More specifically, the invention relates to adenoviral vectors of serotype ShH10, and their therapeutic use in transducing the CRISPR system into ciliary body or choroid plexus to modulate expression of aquaporin or carbonic anhydrase genes.

Methods for the ophthalmic delivery of roflumilast. The inventors have made the surprising discovery that the administration of pharmaceutical compositions comprising roflumilast to the cornea preferentially delivers the drug laterally through the ocular surface and anterior tissues of the eye. In contrast to the delivery of roflumilast to the skin, which primarily travels transversely through the various tissues of the skin, or many other topical ocular pharmaceutical compositions which travel through the cornea to the aqueous humor, the delivery of drug to the eye to the cornea travels laterally to the ocular surface and anterior tissues of the eye. Such methods can result in elevated levels of the drug in the cornea and other ocular surface and anterior tissues of the eye (e.g., iris-ciliary body, sclera, conjunctiva, and aqueous humor) relative to the interior or posterior tissues of the eye.

The invention discloses a method for measuring the thickness change of the crystalline lens of a non-human primate (monkey) through an A-type ultrasonic technology and verifying the relaxation effectof an M receptor antagonist on ciliary body smooth muscle. The method can be used for measuring the influence of test drugs with different concentrations on the thickness of the crystalline lens, knowing the dose-effect relationship between the test drugs and the thickness of the crystalline lens, speculating the influence of the drugs on refractive adjustment, detecting the effective dose and quickly and effectively guiding the preclinical research and development work of new drugs for preventing and treating juvenile myopia. The method disclosed by the invention is simple, stable in technology, good in repeatability, free of tissue trauma to animals and harmless to the health of the whole body. Experimental data obtained from monkeys (animals closest to human beings) has incomparable guiding significance to other animals in clinical tests, so that important transformation medical information is provided for research and development of innovative drugs.

The invention discloses a photobiological regulation therapeutic instrument for treating open-angle glaucoma and a using method. According to the photobiological regulation therapeutic instrument, near-infrared light with a wavelength of 600-800 nm relative to light-emitting viewpoints of a left eye sight glass and a right eye sight glass is set to activate photoreceptors in eye cells of a glaucoma patient, promote light energy to be converted into metabolic energy, reduce intraocular pressure of a glaucoma patient, and provide greater possibility for vision recovery of the patient. On one hand, by irradiating the eyeball-ciliary body, aqueous humor generation is reduced, aqueous humor backflow is promoted, intraocular pressure is reduced, on the other hand, glaucoma optic nerve damage can be reduced and injured optic nerve repair can be promoted through low-dose red light irradiation, and in addition, neurons of optic nerves need high-energy mitochondria ATP to meet tissue requirements, and are very sensitive to glucose consumption or energy deficiency, oxidative stress, and mitochondrial dysfunction. Near-infrared light can promote mitochondrial injury repair and improve mitochondrial functions, and has important application value in optic nerve injury treatment.

The invention discloses a myopia-preventing lighting device for lighting eyeballs and peripheral tissues of the eyeballs. The device comprises a light source and a controller electrically connected with the light source. The light source is used for projecting and lighting the peripheral skin of eyes, penetrating into subcutaneous tissues, penetrating through corneas, pupil iridoids and ciliary body crystals, penetrating through eyeball peripheral tissues, sclera, uvea, choroid and retinal pigment epithelium, and indirectly entering the retina and vitreous body to cause fine biochemical reaction so as to prevent myopia from deepening.

The invention discloses a pulling aid for fixing a lens loop between sclera layers for a seamless posterior chamber type intraocular lens and a using method of the pulling aid. The aid is characterized in that the bottom end of a handle is connected with the left end of a sclera inter-layer needle, and a cavity is formed in the upper portion of the handle; a first channel is formed in the sclera inter-layer needle, the left end of the first channel extends to the left end face of the sclera inter-layer needle, a hole is formed in the side wall of the sclera inter-layer needle, and the right end of the first channel extends to the hole; a second channel is formed in the lower portion of the handle, the upper end of the second channel communicates with the cavity, and the lower end of the second channel communicates with the left end of the first channel; and a sleeve is placed in the cavity, the top end of a loop elastic needle extends out of a first through hole and is connected with apulling piece, a fixing piece is arranged between the sleeve and the cavity, and an ejection device is arranged in the cavity. According to the aid, when the loop elastic needle penetrates into a ciliary body, instant vertical pressurizing penetrating force exists, the damage to the ciliary body is small, and serious complications such as ciliary body superior space disengagement or bleeding canbe effectively avoided.

The invention discloses an intelligent vision low-frequency physiotherapy nursing instrument, and belongs to the technical field of eye nursing treatment. Stimulation waves emitted by a complex wave generating part can be selected according to operation modes so as to meet different use requirements; meanwhile, a curer can achieve different use feelings, stimulation is carried out through a plurality of short-amplitude pulses at the same time, so the stimulation feel is more softer than that of one long pulse; the first electrode pad and the second electrode pad are applied in a dispersed manner, so the feeling is softer than that of a single-pulse stimulation, the stimulation waves are applied in a dispersed manner to the first electrode pad pair and the second electrode pad pair, so that a soft stimulation can be felt, and the upper edge and the lower edge of each waveform of the plurality of stimulation waves can be stimulated at the same time by such a soft stimulation; a plurality of inclined sawtooth waves having tip portions are superposed on the surface of the eye mask, such that a form of adding additional small stimulation to strong stimulation is formed, such that the stimulation feeling is very comfortable, the eyes and the surroundings can be in a relaxed state, the stiff state of the ciliary body can be released, the blood circulation and the lymphatic circulation can be promoted, and the pressure on the eyes can be reduced.

The invention discloses an ocular surface positioner. The whole positioner is dome-shaped, the center of the positioner is of a hollow circular ring, the periphery of the hollow circular ring is of regularly arranged fan-shaped blades, the fan-shaped blades are radially arranged at a fixed included angle, corneal limbus marking lines are marked on the fan-shaped blades, the distance between the corneal limbus marking lines and the central point of the hollow circular ring is 6.0mm, the curvature from the corneal limbus marking lines to the central point of the hollow circular ring is 50, and the curvature radius of each outward blade of each corneal limbus marking line is 12.0mm. In clinical work of ophthalmology department, when accurate positioning is needed when an artificial lens is sutured and fixed or a ciliary body is sutured, accurate measurement and positioning can be achieved through the ocular surface positioner, operation is easy and convenient, precision is high, the operation time can be greatly shortened, and very high practicability is achieved.

The invention belongs to the field of ophthalmology diagnosis and treatment equipment, and particularly relates to a portable glaucoma ciliary body syndrome diagnosis and treatment instrument. The portable glaucoma ciliary body syndrome diagnosis and treatment instrument is composed of a detection module and a diagnosis and treatment module, the detection module comprises a slit lamp microscope module, an intraocular pressure measurement module and an aqueous humor virus detection module, the diagnosis and treatment module comprises an expert system, and the expert system is composed of an expert system database, a diagnosis and treatment module and an interface display module, wherein the data of the detection module is transmitted to the expert system database for diagnosis and treatment analysis and providing of a treatment scheme, the diagnosis and treatment module adopts a GA-BP neural network model to improve the diagnosis precision, establishes a personal file of a patient, and according to the intraocular pressure characteristics, the number and form of corneal hyperpigmentation and the aqueous humor virus infection condition of the patient, a plurality of main treatment methods are established, a targeted treatment scheme is given through dynamic tracking, and harm caused by excessive use of drugs is reduced. The portable glaucoma ciliary body syndrome diagnosis and treatment instrument is low in misdiagnosis rate, integration of various devices is achieved, and the effects of dynamically tracking patient data and rapidly giving a targeted treatment scheme are achieved.

The present invention relates to compounds for use in the treatment of diseases or conditions associated with excessive vascularization of the eye, such diseases or conditions are such as corneal neovascularization, iris neovascularization, ciliary body neovascularization, corneal nebula, choroidal neovascularization, retinal neovascularization, wet age-related macular degeneration, hyperplastic diabetic retinopathy, preterm retinopathy, and ischemic retinopathy.