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Antibacterial peptide and application thereof

An antibacterial peptide, anti-biological technology, applied in the application field of peptide antibiotics

Active Publication Date: 2021-02-09
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the overuse of antibiotics, bacteria have evolved various strategies to evade their killing effects, making the treatment of multidrug-resistant bacterial infections a serious challenge

Method used

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  • Antibacterial peptide and application thereof
  • Antibacterial peptide and application thereof
  • Antibacterial peptide and application thereof

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Embodiment Construction

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0020] The antimicrobial peptide and its application of the present invention are derivative peptides GHaR, GHa4R and GHa11R of the antimicrobial peptide Temporin-GHa (GHa) of P. hainanensis.

[0021] An antimicrobial peptide, the amino acid sequence of which is GHaR (H-Phe-Leu-Gln-Arg-Ile-Ile-Gly-Ala-Leu-Gly-Arg-Leu-Phe-NH 2 ).

[0022] An antimicrobial peptide, characterized in that the amino acid sequence of the antimicrobial peptide is GHa4R (H-Phe-Leu-Gln-Arg-Ile-Ile-Gl...

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Abstract

The invention provides an antibacterial peptide and an application thereof. The antibacterial peptide is derivative peptides GHaR, GHa4R and GHa11R of a Temporin-GHa (GHa), and Belongs to the field ofapplication of peptide antibiotics. Antibacterial peptide GHa is directionally modified to obtain the derivative peptides GHaR, GHa4R and GHa11R. The GHaR, the GHa4R and the GHa11R provided have stronger and faster anti-MRSA activity, and the GHa11R is likely to become a new penetrating peptide. GHaR and GHa11R have high-efficiency anti-MRSA biofilm activity, do not easily generate drug resistance, and have low cytotoxicity and high cell selectivity, so that the GHaR and the GHa11R become novel antibacterial drug candidates with great prospects in treating MRSA infection.

Description

technical field [0001] The invention relates to the technical field of application of peptide antibiotics, in particular to an antibacterial peptide and its application. Background technique [0002] Throughout human history, infectious diseases have been one of the most life-threatening and health-threatening problems in the world. The discovery and development of antibiotics has had a transformative impact on the fight against infectious diseases in humans. However, due to the overuse of antibiotics, bacteria have evolved various strategies to evade their killing effects, making the treatment of multidrug-resistant bacterial infections a serious challenge. Staphylococcus aureus is a common clinical pathogen that can cause a variety of superficial skin infections and systemic diseases (endocarditis and septic arthritis). Epidemiological data in recent years have shown that the number of hospital and community-acquired methicillin-resistant Staphylococcus aureus (MRSA) inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08A61K38/10A61P31/04
CPCC07K7/08A61P31/04A61K38/00Y02A50/30
Inventor 张英霞谢志鹏满初日嘎魏涵淇
Owner HAINAN UNIVERSITY
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