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Preparation method and application of three-dimensional polydopamine

A three-dimensional polydopamine, solution technology, applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, wave energy or particle radiation treatment materials, etc., to promote further development, simple method, excellent biocompatibility and photothermal conversion. rate effect

Active Publication Date: 2021-02-09
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the novel morphology structure of polydopamine materials, especially polydopamine with three-dimensional structure has not been reported yet.

Method used

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  • Preparation method and application of three-dimensional polydopamine
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  • Preparation method and application of three-dimensional polydopamine

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preparation example Construction

[0026] The preparation method of the three-dimensional polydopamine proposed by the present invention comprises the following steps:

[0027] (1) Water, anhydrous low-carbon alcohol and mass percent concentration are mixed with the strong ammonia water of 25%, and the mixing volume ratio of this mixed solution is: water: anhydrous low-carbon alcohol: strong ammonia water=1:(0.3~3) : (0.025~0.1), stirring while heating the mixed solution, the stirring speed is 600r / min, heated to 30~90°C, stirred for 10~30 minutes, to obtain the first solution;

[0028] (2) Add dopamine hydrochloride in the first solution, so that the mass concentration of dopamine hydrochloride in the second solution is: 2.5~4.5g / L, obtain the second solution;

[0029] (3) Add metal iron salt in the second solution so that the mass concentration of the metal iron salt in the second solution is: 0.0003~0.001g / L, the reaction temperature is 30~90°C, the reaction time is 2~36 hours, and the second solution is obt...

Embodiment 1

[0040] (1) water, absolute ethanol and mass fraction are 25% concentrated ammonia water mixed mutually, the mixing volume ratio of this mixed solution is: water: anhydrous low carbon alcohol: concentrated ammonia water=1:0.3:0.025, to mixed solution Stir while heating, the stirring speed is 600r / min, heat to 30°C, and stir for 10 minutes to obtain the first solution;

[0041] (2) Add dopamine hydrochloride in the first solution, so that the mass concentration of dopamine hydrochloride in the solution is: 2.5g / L, obtain the second solution;

[0042] (3) Add ferric chloride hexahydrate to the second solution, so that the mass concentration of the added ferric chloride hexahydrate is: 0.0003g / L, the reaction temperature is 30°C, and the reaction time is 2 hours to obtain the third reaction solution;

[0043] (4) centrifuge separation of the third reaction solution, wash the precipitate obtained by centrifugal separation of water and ethanol, process the washing liquid, repeat thi...

Embodiment 2

[0045] (1) Water, absolute ethanol and mass fraction are 25% concentrated ammonia water and mix each other, the mixing volume ratio of this mixed solution is: water: absolute alcohol: concentrated ammonia water=1:3:0.025, heat the mixed solution limit While stirring, the stirring speed is 600r / min, heated to 60°C, and stirred for 10 minutes to obtain the first solution;

[0046] (2) Add dopamine hydrochloride in the first solution, so that the mass concentration of dopamine hydrochloride in the solution is: 2.5g / L, obtain the second solution;

[0047] (3) Add ferric chloride hexahydrate to the second solution, so that the mass concentration of the added ferric chloride hexahydrate is: 0.0003g / L, the reaction temperature is 60°C, and the reaction time is 7 hours to obtain the third reaction solution;

[0048] (4) centrifuge separation of the third reaction liquid, wash the sediment obtained by centrifugal separation of water and ethanol, process the washing liquid, repeat this st...

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Abstract

The invention relates to a preparation method and application of three-dimensional polydopamine, and belongs to the technical field of functional materials. According to the preparation method, dopamine hydrochloride and metal iron salt are used as raw materials, and the three-dimensional polydopamine is prepared by utilizing a self-polymerization and self-assembly. The three-dimensional polydopamine prepared by the method has the advantages of simple method, adjustable size and morphology and the like, and the requirement of environmental protection is met by taking a common water / alcohol system as a reaction solvent. The preparation method of the three-dimensional polydopamine material provided by the invention can promote further development of related research of polydopamine. The three-dimensional polydopamine prepared by the method disclosed by the invention has an excellent photo-thermal conversion effect, and compared with traditional optical materials, the material shows excellent biocompatibility and photo-thermal conversion rate, and plays a role in promoting the research of a photo-thermal agent. The three-dimensional polydopamine material prepared by the method can beused for photothermal therapy of tumors, so that the three-dimensional polydopamine material has a good medical application prospect.

Description

technical field [0001] The invention relates to a preparation method and application of a three-dimensional polydopamine, belonging to the technical field of functional materials. Background technique [0002] Due to its special optical, electrical and biocompatibility characteristics, polydopamine research has become a research hotspot in many disciplines such as chemistry, materials science and biomedicine in recent years. In the current research, polydopamine has been widely used in catalytic chemistry, free radical scavenging, inkjet printing, tumor therapy, energy materials and many other fields. For now, most of the studies based on polydopamine are to prepare dopamine monomers into zero-dimensional balls or two-dimensional polydopamine films through certain chemical reactions. However, the novel morphology structure of polydopamine materials, especially polydopamine with three-dimensional structure has not been reported yet. [0003] Polydopamine is a material of gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/06A61K41/00A61P35/00
CPCA61K41/0052A61P35/00C08G73/0672
Inventor 梁琼麟艾永建
Owner TSINGHUA UNIV
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