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Method and device for constructing digital disease module

A disease, digital technology, applied in the fields of medical data mining, medical simulation, genomics, etc., can solve the problems of limited evaluation efficiency, scope and speed, difficult to integrate analysis and rapid calculation, and complex data.

Pending Publication Date: 2021-02-23
IND TECH RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Generally speaking, the genome-related data of specific human diseases are complex, with different styles and units, so it is difficult to integrate analysis and quickly calculate
However, the clinical translation effect of the application in cell and animal experimental models is limited
In addition, currently available in vivo efficacy testing systems are limited in their evaluation power, scope and speed

Method used

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  • Method and device for constructing digital disease module
  • Method and device for constructing digital disease module
  • Method and device for constructing digital disease module

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Embodiment Construction

[0032] Aspects of the disclosure are described more fully hereinafter with reference to the accompanying drawings. This disclosure may, however, be embodied in many different forms and should not be construed as limited to any specific structure or function presented throughout this disclosure. Rather, these aspects are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. Based on the teachings herein, one skilled in the art will appreciate that the scope of the present disclosure is intended to encompass any aspect disclosed herein, whether implemented alone or in combination with any other aspect of the disclosure. For example, it may be implemented using any number of means or implementations presented herein. In addition, in addition to the various aspects of the disclosure set forth herein, the scope of the disclosure is intended to cover devices or methods implemented using other s...

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Abstract

A method for constructing a digital disease module includes: determining the relationship between changes of gene / protein expression level of a gene and a disease as a first positive-negative correlation coefficient; determining the relationship between appearance of SNP and the disease as a second positive-negative correlation coefficient; determining a gene product of the gene which is a targetfor disease suppression as a third positive-negative correlation coefficient; determining results of text mining for functions / activities of the gene product of the gene corresponding to the disease as a fourth positive-negative correlation coefficient; determining whether the gene is the upstream gene of the signaling transduction pathway and the relation with the disease as a fifth positive-negative correlation coefficient; adding any three or more coefficients into a first sum of coefficients; and constructing a digital disease module based on the first sum of coefficients to present disease genomic information.

Description

technical field [0001] The disclosure generally belongs to the fields of systems biology, biological information, and gene / protein processing, and more specifically relates to a method and device for constructing digital disease modules. Background technique [0002] Generally speaking, the genome-related data of specific human diseases are complex, with different formats and units, making it difficult to integrate, analyze and quickly calculate. However, the clinical translation effect in cell and animal experimental models is limited. In addition, as far as the current in vivo efficacy test system is concerned, its evaluation performance, scope and speed are limited. [0003] Therefore, there is a need for a method and device for constructing a digital disease module to integrate multiple pieces of relevant information about a specific disease / physiological phenomenon, and then serve as a rapid comparison basis for evaluating drug activity and clinical translation. Cont...

Claims

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Application Information

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IPC IPC(8): G16B20/20G16B20/50G16B30/00G16B40/00
CPCG16B20/20G16B20/50G16B30/00G16B40/00G16B20/40G16H50/50G16H50/20G16B40/20G16H50/70
Inventor 尹书翊潘一红
Owner IND TECH RES INST