Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of filled double drug-loaded nanofiber conductive nerve repair system and preparation method thereof

A nanofiber and nerve repair technology, which is applied in the fields of pharmaceutical formulation, fiber chemical characteristics, drug delivery, etc., can solve the problems of non-degradability and limited application, and achieve excellent biocompatibility, reduced dosage, and strong operability

Active Publication Date: 2022-08-05
WUHAN UNIV OF TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polypyrrole cannot be degraded in the human body, which limits its application in tissue engineering

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of filled double drug-loaded nanofiber conductive nerve repair system and preparation method thereof
  • A kind of filled double drug-loaded nanofiber conductive nerve repair system and preparation method thereof
  • A kind of filled double drug-loaded nanofiber conductive nerve repair system and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] like figure 1 As shown, the present invention provides a preparation method for filling a double drug-loaded nanofiber conductive nerve repair system, comprising the following steps:

[0043] 1) Preparation of PPy nanospheres

[0044] Weigh 2.49g of sodium dodecyl sulfate (SDS) and dissolve it in 140mL of deionized water, stir for 30min, then add 2mL of pyrrole (Py) monomer that has been distilled under reduced pressure twice into the SDS solution, stir for 1h, and weigh 8.58g g FeCl 3 Dissolve in 40 mL of deionized water and stir for 30 min. FeCl 3 The solution was added to the SDS solution, reacted at a constant temperature of 10 °C for 10 h, the solid product was filtered out, washed with deionized water, and dried in a vacuum drying oven at 60 °C for 24 h to obtain black powder polypyrrole (PPy) nanospheres.

[0045] 2) Preparation of PPy / PLA nerve conduit

[0046] Dissolve 1 g of polylactic acid (PLA) with a molecular weight of 150,000 in 10 mL of dichlorometh...

Embodiment 2

[0058] This example is basically the same as Example 1, except that the amount of soft templating agent SDS added in step 1) is changed from 2.49 g to 1.85 g.

Embodiment 3

[0060] This example is basically the same as Example 1, except that the amount of PPy nanospheres added in step 2) is 0.03 g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
viscosityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a conductive nerve repair system filled with double drug-loading nanofibers and a preparation method thereof. The conductive nerve repair system includes a double drug-loaded coaxial nanofiber and a hollow polypyrrole / polylactic acid nerve conduit, wherein: the double drug-loaded coaxial nanofiber is filled in the polypyrrole / polylactic acid nerve conduit; the In the polypyrrole / polylactic acid nerve conduit, polypyrrole nanospheres are uniformly dispersed in polylactic acid; in the double drug-loaded coaxial nanofibers, polylactic acid / vascular endothelial growth factor is used as the shell layer, and chitosan / paeoniflorin is used as the shell layer. for the core layer. First, a polypyrrole / polylactic acid film was prepared, which was rolled into a tube to obtain a polypyrrole / polylactic acid nerve conduit; then double drug-loaded coaxial nanofibers were obtained by coaxial electrospinning technology, and then filled in the nerve conduit. The preparation method is simple and the operability is strong, and the obtained conductive nerve repair system has excellent biocompatibility, mechanical properties, degradation properties and electrical conductivity, and has wide application prospects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a filled double drug-loaded nanofiber conductive nerve repair system and a preparation method thereof. Background technique [0002] Peripheral nerves are distributed on the surface of the human body and are easily injured. Peripheral nerve injury (Peripheral Nerve Injury, PNI) generally does not threaten the life safety of the patient, but if appropriate treatment measures are not taken in time, neuroma or scar tissue will be formed at the distal end of the injured nerve, hindering nerve regeneration, leading to the interruption of nerve channels and triggering. Various harmful consequences, such as sensory loss, chronic pain, disability, deformity, etc., seriously affect the normal life and physical and mental health of patients. The regeneration capacity of injured peripheral nerves is limited, especially when the defect length is greater than 5 mm, it is difficu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/54A61L27/58D01F8/14D01F8/18D01F1/10
CPCA61L27/18A61L27/20A61L27/50A61L27/54A61L27/58D01F8/14D01F8/18D01F1/10A61L2400/12A61L2430/32A61L2300/414A61L2300/216A61L2300/602C08L79/04C08L67/04C08L5/08
Inventor 徐海星闫秀美许沛虎杨海霞许润天李政吕忆菲黄志军
Owner WUHAN UNIV OF TECH