The invention relates to the technical field of deep convolutional neural networks, in particular to a cryoelectron
microscope noise particle image detail reservation
noise reduction method based on
edge enhancement, which comprises the following steps: inputting a cryoelectron
microscope noise particle image into a trained
image noise reduction model, and outputting a noise-reduced cryoelectron
microscope particle image; in the
image noise reduction model, an initial feature map of a noise particle image of the cryoelectron microscope is extracted; inputting the initial feature map into a multi-scale
feature extraction module to capture multi-
scale structure characterization; inputting the multi-scale feature map into an
edge enhancement module to detect and enhance
macromolecule boundary features to generate an edge enhanced feature map; inputting the
edge enhancement feature map into a detail retention module for
processing and retaining structure details to generate a detail enhancement feature map, and performing
convolution processing to generate a prediction
noise component; and subtracting the predicted
noise component from the cryo-
electron microscope noise particle image to obtain a noise-reduced cryo-
electron microscope particle image. According to the invention, the
noise reduction quality of the noise particle image of the cryoelectron microscope can be improved.