Anti-adhesion and anti-blue light injury care solution for eyes and preparation method thereof

A nursing solution and anti-adhesion technology, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems that have not yet been seen, and achieve long storage time and biocompatibility. The effect of good sex and high safety

Active Publication Date: 2021-03-02
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no reports on the eye care solution for anti-adhesion and

Method used

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  • Anti-adhesion and anti-blue light injury care solution for eyes and preparation method thereof
  • Anti-adhesion and anti-blue light injury care solution for eyes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026]Example 1 Preparation of samples of each group of eye care solution for anti-adhesion and blue light damage

[0027]According to the component ratios in Table 1, prepare eye care solutions for anti-adhesion and blue light damage. The samples of the experimental group were prepared in a sterile environment as follows:

[0028]Step 1) The heparin-poloxamer copolymer is dissolved in 2 times the mass of ethanol, and lycopene, lutein, zeaxanthin and ganglioside are added and mixed to form a uniform solution;

[0029]Step 2) Add sulfobutyl ether-β-cyclodextrin to water to dissolve, add polyol and mix to form a uniform solution;

[0030]Step 3) Add the solution obtained in step 1) several times in small amounts to the solution obtained in step 2), mix well, add bacteriostatic agent, pH adjuster, osmotic pressure adjuster, and mix well to obtain the anti-adhesion of the eye And anti-blue light damage care solution.

[0031]Control sample: Prepared according to the method of the experimental group.

[0...

Example Embodiment

[0037]Example 2 Stability investigation

[0038]In this example, the eye anti-adhesion and blue light damage prevention solution prepared in Example 1 was used to investigate the stability. The samples of the experimental group and the control group were placed at 20°C for three months in the dark, and the following indicators were observed The change.

[0039](1) Appearance changes: Observe the uniformity of the system with naked eyes, whether there is discoloration, delamination or turbidity, etc.

[0040](2) Changes in the content of lycopene, lutein and zeaxanthin: HPLC method was used to determine the content of lycopene, lutein and zeaxanthin in the system, and to evaluate whether they had changed.

[0041](3) Changes in the number of microorganisms: Refer to the pharmacopoeia method to check the number of microorganisms in the system and evaluate whether they have changed.

[0042](4) Changes in pH and osmotic pressure: Refer to the pharmacopoeia method to measure the pH and osmotic pressur...

Example Embodiment

[0046]Example 3 Evaluation of drug release behavior

[0047]Take 1 mL of each sample of the experimental group and the control group prepared in Example 1, place them in a 3500Da dialysis bag, put the test tube in a beaker containing 1000 mL of distilled water, place it in a 37°C water bath, put a magnetic stirrer, and adjust Rotation speed is 50r / min, sampling at intervals and supplementary sampling with the same volume of distilled water to ensure the sink condition. The sample solution was filtered through a 0.45μm microporous filter membrane, diluted by an appropriate multiple, and then the content of lycopene, lutein and zeaxanthin was determined by liquid chromatograph, and the drug release behavior of the three was counted. According to whether the release curve is stable and the duration of the grading from 1 to 10, "10" represents the best (the release curve is stable and has a long duration), and "1" represents the worst (the release curve fluctuates greatly and lasts for a l...

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Abstract

The invention provides an anti-adhesion and anti-blue light injury care solution for eyes and a preparation method thereof. The anti-adhesion main components in the care solution are heparin poloxamercopolymer, sulfobutyl ether beta cyclodextrin and ganglioside, and the anti-blue light injury main components are lycopene, lutein and zeaxanthin. Ethanol, polyol, a bacteriostatic agent, a pH regulator and an osmotic pressure regulator are added into the care solution. The anti-adhesion and anti-blue light injury care solution for eyes plays a long-acting controlled release role and an anti-adhesion role.

Description

Technical field[0001]The present invention relates to an eye care solution, in particular to a care solution that exerts eye anti-adhesion and anti-blue light damage on the eyes.Background technique[0002]With the popularization and application of mobile phones and computers in modern society, the problem of eye fatigue has become more and more serious. Prolonged eye fatigue and wearing contact lenses will cause the tears in the eyes to decrease and local tissue adhesion. In addition, various injuries can also cause adhesion of eye tissues. Ocular tissue adhesion will lead to many complications, such as inverted or protruding eyeballs, and diplopia caused by obstruction of eye movement, which seriously affects visual function and appearance. Therefore, choosing a reasonable anti-adhesion method has important practical significance.[0003]"Blu-ray" is contained in electronic products such as mobile phones and computers in daily applications. Blue light is the most powerful light in vis...

Claims

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Application Information

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IPC IPC(8): A61K31/01A61K31/047A61K47/36A61K47/10A61K47/40A61K47/26A61P27/02
CPCA61K31/01A61K31/047A61K9/0048A61K47/36A61K47/10A61K47/40A61K47/26A61P27/02A61K2300/00
Inventor 赵应征鲁翠涛
Owner WENZHOU MEDICAL UNIV
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