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Method for detecting artery plaque stability

A technique for the stability of arterial plaques, applied in the field of laboratory medicine and cardiovascular and cerebrovascular diseases, can solve problems such as the failure to further confirm the correlation between Cp infection and coronary heart disease, achieve good social value, good economic value prospects, and easy replication Effect

Inactive Publication Date: 2021-03-05
孙余华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, prospective clinical studies of antibiotics used in patients with coronary heart disease in European and American countries failed to further confirm the correlation between Cp infection and coronary heart disease (Grayston JT, et al. N Engl J Med, 2005, 325: 1637-1645. Cannon CP, et al. N Engl J Med, 2005, 325:1646-1654)

Method used

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  • Method for detecting artery plaque stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1, no blood lipid disorder, no hypertension, no diabetes, no carotid plaque, Cp infection negative.

Embodiment 2

[0045] Example 2, hypertension, diabetes, carotid plaque, mainly fibrous plaque or calcified hard plaque, no rupture, negative for Cp infection, sterile arterial plaque, belongs to stable plaque.

Embodiment 3

[0046] Example 3, dyslipidemia, mixed plaque, rupture, Cp infection positive, Cp nucleic acid 7689 copies / 10 4 Peripheral blood mononuclear cells and bacterial arterial plaques belong to unstable arterial plaques. It is recommended to implement a drug regimen for Cp infection.

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Abstract

The invention relates to the field of laboratory medicine and cardiovascular and cerebrovascular diseases. The invention relates to a method for assaying human peripheral blood, in particular to a method for detecting artery plaque stability. According to the method, the stability of an artery plaque is judged by detecting chlamydia pneumoniae infection in the peripheral blood and in the artery plaque by inspecting a specific nucleotide sequence of a chlamydia pneumoniae genome in the peripheral blood. The method specifically comprises the following three aspects that the chlamydia pneumoniaeinfection in the peripheral blood is used as a new blood risk factor for arterial plaque occurrence and development and related diseases; according to the novel method for detecting the artery plaquestability, the inflammatory response of the artery plaque is typed and staged according to the infection condition and the infection degree of the chlamydia pneumoniae in the artery plaque of an individual; and according to the detected infection condition of the chlamydia pneumoniae in human peripheral blood and artery plaques, a method for implementing the application in a medication scheme forstabilizing the artery plaques and reducing inflammatory response is determined. The method has good social value and economic value.

Description

technical field [0001] The present invention relates to a method for testing the extracted human peripheral blood, in particular to a method for detecting Chlamydia pneumoniae infection in arterial plaque by detecting Chlamydia pneumoniae in human peripheral blood through PCR technology, and further relates to detecting the stability of arterial plaque and determining the stability of the implementation Methods of use in plaque drug regimens. The invention relates to the fields of laboratory medicine and cardiovascular and cerebrovascular diseases. [0002] Background of the invention [0003] Arterial plaque, also known as atherosclerotic plaque, is the main cause of cardiovascular and cerebrovascular diseases. At present, blood risk factors related to the occurrence and development of arterial plaques include high total cholesterol, high low-density lipoprotein cholesterol, high small and dense low-density lipoprotein cholesterol, high triglycerides, high blood sugar, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/04C12R1/01
CPCC12Q1/689C12Q2600/112
Inventor 孙余华
Owner 孙余华