Composition containing taurine and allopurinol and medical application of composition
A technology of taurine and allopurinol, which is applied in the field of compositions containing taurine and allopurinol, can solve the problems of not reaching clinical treatment goals, lack of atherosclerosis, and failure to improve the effect of atherosclerosis
Active Publication Date: 2021-03-19
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology
[0005] Clinically, xanthine oxidase inhibitors such as allopurinol or febuxostat are usually used to reduce the formation of uric acid, but the results of large-scale clinical trials show that although the administration of xanthine oxidase inhibitors has achieved a certain effect on controlling uric acid, it does not Did not improve the effect of atherosclerosis, did not reduce the incidence of cardiovascular diseases such as myocardial infarction, stroke, heart failure, and did not reach the goal of clinical treatment
[0006] There is currently a lack of effective drugs against atherosclerosis caused by hyperuricemia
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[0050] The content of the present invention is further explained or illustrated by examples below, but these examples should not be construed as limiting the protection scope of the present invention.
[0051] It should be noted that various reagents used in the following examples are known in the art and can be obtained commercially.
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Abstract
The invention provides a composition comprising taurine and allopurinol as main components, wherein the ratio of the content of taurine to the content of allopurinol is 20: 1 to 1: 1 by mass ratio. The composition can be used for preventing or treating hyperuricemia or hyperuricemia complications.
Description
technical field [0001] The present invention relates to a composition containing taurine and allopurinol, especially, the composition can be used for preventing or treating hyperuricemia or complications of hyperuricemia. Background technique [0002] Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia (HUA). Hyperuricemia is caused by overproduction and / or underexcretion of uric acid in the body, and can be divided into two categories: primary hyperuricemia and secondary hyperuricemia. Clinically, hyperuricemia is defined as serum uric acid higher than 420 μmol / L (7.0 mg / dL) in males and higher than 350 μmol / L (5.8 mg / dL) in females. [0003] Epidemiological surveys show that the incidence rate of hyperuricemia in my country is 13%, of which men account for about 18%, women account for about 8%, and the total affected population reaches 180 million. fourth highest". [0004] Simple hyperuricemia is not a fa...
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IPC IPC(8): A61K31/185A61K31/519A61P19/06A61P9/10
CPCA61K31/185A61K31/519A61P19/06A61P9/10A61K2300/00
Inventor 王涛张祎包瑞霞刘梦扬陈倩吴昱铮王丹
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE


