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Non-permeable polysiloxane-containing block copolymer and its preparation method and application

A technology of block copolymer and polysiloxane, applied in the field of sterilization materials, can solve problems such as toxicity and increased risk

Active Publication Date: 2022-03-25
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some small molecule bactericides or disinfectants, such as quaternary ammonium salts, have strong permeability to the skin, penetrate through the epidermal barrier of the skin, enter the human body circulation, and have certain toxicity to the human body, resulting in increased potential risks

Method used

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  • Non-permeable polysiloxane-containing block copolymer and its preparation method and application
  • Non-permeable polysiloxane-containing block copolymer and its preparation method and application
  • Non-permeable polysiloxane-containing block copolymer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: Preparation of non-permeable polysiloxane-containing block copolymers

[0055] The synthetic route is:

[0056]

[0057] (1) Synthesis of polydimethylsiloxane-polymethylvinylsiloxane block copolymer:

[0058] Under nitrogen protection, in an eggplant-shaped reaction flask, 20 g of trimethyltrivinylcyclotetrasiloxane (D 3 v ) into 40g of tetrahydrofuran, add 4mL of n-butyllithium (n-BuLi), the first reaction, the temperature of the first reaction is 0 ℃, the time of the first reaction is 12 hours, then add 20g of n-BuLi Methylcyclotrisiloxane (D 3 ), the second reaction, the temperature of the second reaction is 0 ℃, the time of the second reaction is 12 hours, then add dimethyl vinyl chlorosilane (THF), stir, the third reaction, the third The reaction temperature is 0°C, the third reaction time is 1 hour, and the separation process is rotary evaporation at 130°C and filtration to obtain polydimethylsiloxane-polymethylvinylsiloxane embedded Segment cop...

Embodiment 2

[0063] Example 2: Preparation of non-permeable polysiloxane-containing block copolymers

[0064] Compared with Example 1, the difference of Example 2 is only that 20g of hexamethylcyclotrisiloxane in Example 1 is changed into 5g of hexamethylcyclotrisiloxane, and the obtained polydimethylcyclotrisiloxane The number average molecular weight (M n ), weight average molecular weight (M w ) and molecular weight distribution index (M w / M n ) are: 5000, 6200 and 1.24 respectively.

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Abstract

The invention belongs to the technical field of bactericidal materials, and discloses a non-permeable block copolymer containing polysiloxane, a preparation method and application thereof. A polysiloxane-containing block copolymer having a structure of formula (I): wherein, the value of n is 1-280, and the value of m is 30-400; b represents that between the long chains in two brackets is Block structure; * indicates the position of substitution. Compared with existing commercially available small molecule quaternary ammonium salt fungicides, the polysiloxane-containing block copolymer with formula (I) structure proposed by the present invention has a larger molecular weight, because its molecular volume is huge, it is difficult to It penetrates through the epidermis of the skin and can be effectively adsorbed on the surface of the skin, especially suitable for use as a long-acting fungicide for the epidermis.

Description

technical field [0001] The invention belongs to the technical field of bactericidal materials, and in particular relates to a non-permeable polysiloxane-containing block copolymer and a preparation method and application thereof. Background technique [0002] People inevitably encounter some harmful microorganisms in daily life, such as bacteria, fungi, molds, etc., so it is often necessary to use antibacterial agents to inhibit or kill such microorganisms to prevent the contamination and infringement of microorganisms such as bacteria. [0003] Disinfection of human skin surface is very necessary. However, some small molecule bactericides or disinfectants, such as quaternary ammonium salts, have strong permeability to the skin, penetrate through the epidermal barrier of the skin, enter the human body circulation, and have certain toxicity to the human body, resulting in increased potential risks. [0004] Therefore, it is desired to provide a non-permeable bactericide, whi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/44A61K31/80A61P31/00A61P31/04A61P31/10
CPCC08G77/44A61K31/80A61P31/00A61P31/04A61P31/10
Inventor 张安强何诗琦张德强钟伟强林雅铃
Owner SOUTH CHINA UNIV OF TECH