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Application of MAGI3 in prediction of prognosis or chemosensitivity of colorectal cancer patient

A colorectal cancer, patient technology, applied in the field of biomedicine, can solve the problems of limited information and the degree of colorectal cancer prognosis cannot be well quantified and integrated.

Active Publication Date: 2021-03-19
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional clinicopathological factors, including intestinal obstruction / perforation, T4 tumor, lymphovascular invasion, histological grade 3-4, submitted lymph nodes <12, positive resection margin, etc., can provide certain prognostic information for colorectal cancer patients , but the information contained in these risk factors is limited, and the degree to which each factor affects the prognosis of colorectal cancer cannot be well quantified and integrated

Method used

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  • Application of MAGI3 in prediction of prognosis or chemosensitivity of colorectal cancer patient
  • Application of MAGI3 in prediction of prognosis or chemosensitivity of colorectal cancer patient
  • Application of MAGI3 in prediction of prognosis or chemosensitivity of colorectal cancer patient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Example 1 Correlation analysis between MAGI3 expression and prognosis of colorectal cancer

[0084] 1. Database data analysis

[0085] 1. Collect data

[0086] The clinical information of colorectal cancer patients (374 cases) in the TCGA database (see Table 1) and the clinical information of patients (566 cases) in the GSE40967 dataset (see Table 2) were extracted, and analyzed after integration with the MAGI3 expression value.

[0087] Table 1 Clinical information of colorectal cancer patients in TCGA database

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[0092] Table 2 Patient information in the GSE40967 dataset

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[0098] 2. Results

[0099] The results of both databases showed that compared with patients without recurrence after radical operation, the mRNA expression of MAGI3 in cancer tissues of patients with recurrence was significantly reduced, and the difference was statistically significant ( fi...

Embodiment 2

[0127] Example 2 Correlation analysis between MAGI3 expression and sensitivity to chemotherapy drugs in patients with colorectal cancer

[0128] 1. Collect data

[0129] Patients with chemotherapy and efficacy information included in the TCGA colorectal cancer database were extracted. Please see Table 4 for patient information.

[0130] Table 4 is used for the patient information of this embodiment research

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[0135] 2. Analysis

[0136] According to the median expression value of MAGI3 mRNA, the collected patients were divided into two groups with high and low expression of MAGI3. It was found that the effective rate of chemotherapy (complete remission, partial remission) in the high expression MAGI3 group was higher than that in the low expression group ( Figure 7 A), at the same time, the expression level of MAGI3 in the drug-resistant patient group (stable disease, disease progression) was lower than that of the effective...

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Abstract

The invention relates to application of MAGI3 in prediction of prognosis or chemosensitivity of a colorectal cancer patient. Researches prove that the MAGI3 in patients with postoperative recurrence and patients with short lifetime shows low expression, so that the MAGI3 can be used as a useful prognostic factor for predicting whether the postoperative recurrence occurs or not or predicting the lifetime of patients with colorectal cancer . In addition, the invention proves that the effective rate of colorectal cancer patients with high MAGI3 expression level on a chemotherapy scheme based on 5-Fu is higher than that of patients with low expression MAGI3, so that the MAGI3 can be used as an index for predicting the chemotherapy effectiveness of the colorectal cancer patients. Accordingly, aproduct for predicting prognosis of colorectal cancer patients and a drug for enhancing chemosensitivity of the colorectal cancer patients can be developed, so that prognosis of the patients is improved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an application of MAGI3 in predicting the prognosis or chemotherapy sensitivity of colorectal cancer patients. Background technique [0002] Colorectal cancer (CRC) is one of the most common malignant tumors. According to the latest data on global cancer status from the World Health Organization, the mortality rate of colorectal cancer ranks third in solid tumors. In recent years, with the development of the economy and the improvement of living standards, the rate of increase in the incidence rate in my country has reached twice the international average growth rate. In Shanghai and other eastern coastal cities, the incidence rate has reached the second place among solid tumors, becoming the leading cause of death. one of the main diseases. [0003] Colorectal cancer is a large class of diseases. In recent years, the research on its occurrence and development mechanism, treatment and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574G01N33/573A61K45/00A61K45/06A61P35/00
CPCC12Q1/6886G01N33/57419G01N33/57484G01N33/573A61K45/00A61K45/06A61P35/00C12Q2600/158C12Q2600/118C12Q2600/136C12Q2600/106G01N2333/91235
Inventor 贺俊崎王海波
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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