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Ultramicro Raman spectrum detection device

A Raman spectroscopic detection and ultra-trace technology, which is applied in the field of precision medical scientific research experimental equipment to achieve the effect of convenient acquisition and movement, and efficient collection efficiency.

Active Publication Date: 2021-03-19
CHINA JILIANG UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0005] In order to solve the above-mentioned deficiencies in the prior art, the object of the present invention is to provide an ultra-trace Raman spectroscopy detection device, which solves the problems of micron and nanometer-scale cells or molecules by designing a spatial super-resolution detection optical path and an ultra-high-sensitivity detection device. Problems of Sampling and Precise Measurement of Raman Spectroscopy

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Embodiment Construction

[0034] The present invention will be described in detail below in conjunction with the specific embodiments shown in the accompanying drawings, but these embodiments do not limit the present invention, those of ordinary skill in the art make structural, method, or functional changes based on these embodiments All are included in the scope of protection of the present invention.

[0035] Such as figure 1 An ultra-trace Raman spectroscopy detection device is shown, comprising:

[0036] The optical tweezers unit includes a first optical fiber F1 and a first laser L1, and utilizes the first laser L1 to emit a light beam that enters the annular core of the first optical fiber F1 and converges at the lower fiber end of the first optical fiber F1 to form optical tweezers for capturing cells;

[0037] The manipulation unit includes a first mechanical arm M with a first degree of freedom, a second mechanical arm N with a second degree of freedom, and an observation device B. The secon...

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Abstract

The invention discloses an ultramicro Raman spectrum detection device, which combines optical fiber optical tweezers and an ultramicro detection device of a Raman spectrum, can capture single-cell-scale substances such as cells through the optical tweezers, and moves and places the substances into a V-shaped groove of a Raman detection optical fiber probe below the optical tweezers, so that to-be-detected substances are efficiently utilized, the collection efficiency of Raman scattered light is improved, and a precise Raman spectrum is obtained.

Description

technical field [0001] The invention belongs to the field of precision medical scientific research experimental equipment, and in particular relates to an ultra-micro Raman spectrum detection device. Background technique [0002] At present, fiber optical tweezers technology is making rapid progress in biomedicine, especially in the capture and movement of molecules at the micron and nanometer levels, which is of great help to single-cell medicine; the current Raman spectroscopy technology can do macroscopically To obtain the "fingerprint" of the substance, but at the micro-nano scale, to obtain the precise Raman spectrum of the single-cell level substance and to fully interact with the sample substance and the excitation light still needs to be further explored. Therefore, it is necessary to combine fiber optic tweezers and Raman spectroscopy to achieve ultra-micro sampling detection and ultra-high sensitivity Raman spectroscopy. [0003] The existing technology (patent CN...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65G01J3/44G01J3/02G01J3/10
CPCG01N21/65G01J3/4412G01J3/0218G01J3/0208G01J3/10
Inventor 冯笛金尚忠姜丽金怀洲
Owner CHINA JILIANG UNIV
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