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Gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas

A non-invasive, pituitary adenoma technology, applied in the field of biomedicine, can solve the problem of inability to accurately diagnose the invasiveness of non-functioning pituitary adenomas

Active Publication Date: 2021-04-09
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1
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Problems solved by technology

Recent studies have found that the invasiveness of non-functioning pituitary adenomas has a certain correlation with the above-mentioned cell lineage sources and imaging features; some studies have also reported molecular expression changes related to the invasiveness of non-functioning pituitary adenomas, but there is no evidence to date. Methods for Accurately Diagnosing the Aggressiveness of Nonfunctioning Pituitary Adenomas

Method used

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  • Gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas
  • Gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas
  • Gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas

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Experimental program
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Embodiment 1

[0088] Example 1 Screening and verification of genes related to aggressive non-functioning pituitary adenoma

[0089] 1. Sample collection (clinical diagnosis) and study supervision

[0090] Informed consent was obtained from all individual participants in the study. The study recruitment process and protocol were approved by the Peking Union Medical College Hospital Ethics Review Board (No. S-551). Patients who underwent transsphenoidal surgery in Peking Union Medical College Hospital between May 2012 and July 2017 were collected, and their pituitary adenomas were collected. 61 NF-PAs underwent RNA-seq, and 143 NF-PAs underwent TaqMan quantitative RT-PCR and tissue microarray. NF-PAs were diagnosed based on clinical manifestations, hormone tests, and magnetic resonance imaging (MRI). Additionally, immunohistochemical staining was performed for all anterior pituitary hormones and transcription factors to differentiate NF-PA subtypes (Table 1). In this study, all NF-PAs had...

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Abstract

The invention discloses a gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas. The gene combination consists of the following genes of INSM1, Jun, JunB, RHOU, RHOB, EZR, LLGL2, SNX33, SPIRE2, MLF1, HSPA2, CDKN1A, ERN1, NR2F2, GAS2, CDK6, SFRP1, EMILIN2, CD9 and SEMA7A. By detecting the expression level of the gene combination, the non-invasive and invasive non-functional pituitary adenomas can be distinguished.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a gene combination for distinguishing non-invasive and invasive non-functional pituitary adenomas. Background technique [0002] Pituitary adenomas (Pituitary Tumors, PA) are a group of heterogeneous diseases originating from the anterior pituitary cells, accounting for about 10%-15% of intracranial tumors, and are common adenomas of monoclonal origin. The incidence rate of the population is 1 / 100,000, and some reports can be as high as 7 / 100,000. With the rapid development of molecular biology, cell biology, genetics, immunology and other disciplines and new technologies, many scholars have studied the factors related to its pathogenesis from the cellular and molecular levels, in order to expect its pathogenesis and invasion. , recurrence correlation to predict and guide clinical treatment, has made some progress. At present, it is believed that most pituitary adenomas, including non-f...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G01N33/574
CPCC12Q1/6886C12Q2600/112C12Q2600/158G01N33/57407G01N33/57488
Inventor 包新杰余佳王任直王耕超王小爽于姗
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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