Preparation method of dandelion extract, dandelion extract and application of dandelion extract

A technology of dandelion extract and dandelion, which is applied in the field of DNA damage, can solve the problems of lack of dandelion extract, etc., and achieve the effect of good effect, low energy consumption and easy operation

Pending Publication Date: 2021-04-16
COSMAX CHINA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, this area lacks the dandelion extract that can be widely used in the field of cosmetics

Method used

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  • Preparation method of dandelion extract, dandelion extract and application of dandelion extract
  • Preparation method of dandelion extract, dandelion extract and application of dandelion extract
  • Preparation method of dandelion extract, dandelion extract and application of dandelion extract

Examples

Experimental program
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Effect test

preparation example Construction

[0052] The preparation method of dandelion extract of the present invention comprises the following steps:

[0053] (a) Take the dried whole herb of dandelion, crush it to less than 0.1mm, and sterilize;

[0054] (b) adding an extraction solvent to the sterilized pulverized dandelion, and extracting the crude extract with stripping extraction equipment;

[0055] (c) obtain the crude filtrate after the crude extract obtained in the microfiltration membrane negative pressure filtration step (b) for two times;

[0056] (d) After adding an extraction solvent to the coarse filtrate in step (c), filter it with an ultrafiltration membrane to obtain the final product, namely the dandelion extract.

Embodiment 1

[0057] Example 1 Preparation of clock rhythm disorder repairing dandelion extract

[0058] In the following examples and comparative examples of the present invention, the clock rhythm disorder repairing dandelion extract was prepared by the following process.

[0059] 1. Preparation of Dandelion Extract

[0060] (1) After pulverizing the dried raw material of the whole dandelion herb, pass through a 200-mesh sieve;

[0061] (2) Add a certain amount of 1,3 butanediol, 1,2 hexanediol, ethylhexylglycerin and deionized water for extraction, this is the extraction solvent.

[0062] (3) The extraction equipment adopts Distek series medicinal dissolution apparatus, the mass ratio of raw material to extraction solvent is 0.02:1-0.16:1, the extraction temperature is 25-55°C, and the extraction time is 0.5-6h to obtain the crude extract;

[0063] (4) cooling the crude extract obtained in step (3) to 20-30° C., and filtering with a microfiltration membrane under negative pressure to o...

Embodiment 2

[0087] Embodiment 2 Ultraviolet spectrophotometer full-wavelength long-scan determines extraction process condition

[0088] Full-wavelength scanning: use the extraction solvent as a blank sample to calibrate the full-wavelength scanning baseline; using Distek pharmaceutical dissolution equipment, the extraction solvent is a mixture of 1,3 butanediol, 1,2 hexanediol, ethylhexylglycerin and deionized water Composite solvent, extraction material-liquid ratio: 0.02:1-0.16:1, extraction time: 0.5-6h; extraction temperature: 25-55°C. Such as the integral of the full-wavelength absorption peak area of ​​the dandelion extract (also referred to as plant extract in the present invention) obtained under each extraction parameter condition in Table 1. Under each process condition, the peak area and comparative example 1 peak area ratio process determine the conditions.

[0089] Experimental results: See Table 2, plant extracts 1-19 and comparative examples Process parameters:

[0090] ...

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Abstract

The invention provides a preparation method of a dandelion extract, the dandelion extract and application of the dandelion extract. The dandelion extract is prepared by adopting dissolution extraction equipment, and an extraction solvent used in the preparation method is a composite solvent composed of 1,3-butanediol, 1,2-hexanediol, ethylhexylglycerin and deionized water. The obtained dandelion extract prepared by a dissolution method has a good effect in the aspect of clock rhythm disorder repair, and then the phenomena of skin aging, wrinkle formation, skin color loss, skin sagging and the like caused by clock rhythm disorder are repaired. The raw materials are pure natural plants and are mild in property, easy to absorb and free of irritation; and the extraction process adopts a non-ethanol immersion extraction process, meets the requirements of people for safety, effectiveness and zero burden of cosmetics, and can be widely applied to skin care cosmetics and the like.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to an extract which uses dandelion extract as an active ingredient and has remarkable repairing effect on DNA damage caused by clock rhythm disorder, and a preparation method and application thereof. Background technique [0002] The skin, like all organs of the body, is aging. The causes of skin aging include skin aging caused by body aging (intrinsic factor) and skin aging caused by various harmful environmental exposures (external factor). When the body's clock rhythm is disturbed, it often leads to a series of symptoms such as DNA damage, oxidative stress and inflammation. For example, after being irradiated, the formation of pyrimidine dimers (CPDs) and 6-4 photodegradation products (6-4PPs) is induced, which leads to cell DNA damage, cell aging and death, and then causes a series of skin problems. Prior art: Comet assay, also known as single cell gel electrophoresis (SCGE...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/08
Inventor 金荣熙魏茂林周春亚齐秋月周秋娜张贤尽金延埈金炫延
Owner COSMAX CHINA INC
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