Clotrimazole pharmaceutical composition and preparation method thereof

Abstract

The invention relates to a clotrimazole pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines. According to the technical scheme, every 10000 clotrimazole vaginal tablet composition contains 5000 g of clotrimazole, 1150 g of lactose, 2450 g of microcrystalline cellulose, 25 g of povidone, 100 g of calcium lactate, 250 g of lactic acid, 724-1069 g of croscarmellose sodium (400 g of croscarmellose sodium is added externally, and 324-669 g of croscarmellose sodium is added internally), 556 g of ethyl cellulose, 15 g of polyethylene glycol and 100 g of magnesium stearate. By implementing the technical scheme, the clotrimazole pharmaceutical composition which is stable in vivo and in vitro is obtained.

Description

technical field [0001] The invention relates to a clotrimazole pharmaceutical composition and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] For healthy women of childbearing age, the vaginal pH is generally between 3.8 and 4.5. This is because the lactase secreted by Lactobacillus kescheri degrades glycogen into lactic acid, creating an acidic environment that prevents the growth of pathogenic microorganisms. [0003] Mycotic vaginitis caused by Candida is a common clinical vulvovaginal inflammatory disease, mostly caused by Candida albicans. When the systemic or local immunity of the vagina declines, Candida albicans transforms into hyphae and enters the vaginal tissue , cause fungal vaginitis, cause vaginal flora imbalance, produce symptoms such as increased leucorrhea, itching, and dysuria, which seriously affect the quality of life of patients. Antifungal drugs are used clinically to treat mycotic vaginitis. ...

AI Technical Summary

Problems solved by technology

[0008] Provide a clotrimazole vaginal tablet composition and preparation method that are stable both in vivo