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Coptis chinensis, astragalus membranaceus, pseudo-ginseng and rehmannia compound medicine for preventing and treating diabetes mellitus and complications

A technology for diabetes and complications, applied in the field of traditional Chinese medicine, can solve the problems of difficult control, serious side effects and drug resistance of western medicine

Pending Publication Date: 2021-05-04
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The treatment of diabetes in modern medicine mainly includes insulin secretion promoters, α-glucosidase inhibitors, growth factor antagonists, angiotensin-converting enzyme inhibitors, etc., such as insulin, biguanides, sulfonylureas, etc., but most of them have severe Side effects and drug resistance; with the prolongation of the course of diabetes, various chronic complications will appear to varying degrees, and once complications occur, it is difficult for Western medicine to control them

Method used

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  • Coptis chinensis, astragalus membranaceus, pseudo-ginseng and rehmannia compound medicine for preventing and treating diabetes mellitus and complications
  • Coptis chinensis, astragalus membranaceus, pseudo-ginseng and rehmannia compound medicine for preventing and treating diabetes mellitus and complications
  • Coptis chinensis, astragalus membranaceus, pseudo-ginseng and rehmannia compound medicine for preventing and treating diabetes mellitus and complications

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 The preparation of the application medicine

[0042] Preparation prescription: Coptidis 313g, Astragalus 939g, Panax notoginseng 188g, Dihuang 626g

[0043] Preparation:

[0044] 1. Coptis chinensis is crushed into coarse powder, and Panax notoginseng is crushed into coarse powder.

[0045] 2. Take Coptis chinensis coarse powder and Panax notoginseng coarse powder, add 5 times the amount of 70% ethanol, heat and reflux twice, each time for 2 hours, filter, combine the filtrate, recover ethanol and concentrate to a relative density of 1.26-1.28 (50°C) thick paste, set aside.

[0046] 3. Take astragalus and rehmannia glutinosa, add 8 times the amount of water to decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear liquid with a relative density of 1.12-1.16 (50°C) (1ml contains 1g of crude drug). Paste, add ethanol to make the alcohol content reach 70%, let it stand for 24 hours, filter, the filtrate recov...

Embodiment 2

[0049] Embodiment 2 The effect of the medicine of the present application on type 2 diabetes mice

[0050] 1 Experimental method

[0051] 1.1 Modeling and administration

[0052] After one week of adaptive feeding, C57 mice were randomly divided into blank group and model group. The blank group was fed with conventional feed, and the model group was fed with high-fat and high-sugar feed (KK feed). After feeding for 4 weeks, the animals in the model group were fasted without food and water for 12 hours, and were injected intraperitoneally with 100 mg / kg of streptozotocin (STZ); the blank group was only injected with an equal volume of citric acid-sodium citrate buffer. After 1 week, taking blood from the tip of the tail to measure the random blood glucose greater than 12.0mmol / L was considered as successful modeling, and the successful modeling mice were randomly divided into model group and metformin group (220mg / kg) according to the principle of blood glucose and body weigh...

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Abstract

The invention provides a traditional Chinese medicine compound medicine consisting of coptis chinensis, astragalus membranaceus, pseudo-ginseng and rehmannia and an application of the traditional Chinese medicine compound medicine to prevention and treatment of diabetes mellitus and diabetes mellitus complications. The compound medicine disclosed by the invention has good prevention and treatment effects on various diabetic complications such as diabetes mellitus, diabetic heart diseases, diabetic kidney diseases and diabetic retinopathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and the field of diabetes treatment, and in particular relates to Chinese compound medicines of coptis, astragalus, notoginseng and rehmannia root and their application in preventing and treating diabetes and diabetic complications. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by chronically elevated blood glucose levels, caused by defects in insulin secretion and / or action. Its morbidity and mortality are increasing year by year. According to the statistics of the World Health Organization, the number of diabetic patients in the world has reached 176 million in 2000, and it is estimated that the number of patients will double to 370 million by 2030. Diabetes is not a single disease, but a syndrome caused by multiple causes. It is the result of multiple factors including genetic and environmental factors. Insulin is synthesized and secreted by pan...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P3/10A61P9/00A61P13/12A61P9/10A61P9/06A61P27/02
CPCA61K36/258A61K36/481A61K36/718A61K36/804A61K2236/331A61K2236/333A61K2236/39A61P3/10A61P9/00A61P9/06A61P9/10A61P13/12A61P27/02A61K2300/00
Inventor 徐惠波孙晓波丁涛刘博王鑫温富春纪凤兰
Owner JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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