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Novel implant system for delivering beneficial substances to animals

A technology of beneficial substances and animals, which is applied in the direction of pharmaceutical devices and other medical devices, and can solve the problems of inability to achieve delivery rate and start-up time

Inactive Publication Date: 2021-05-04
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the disclosed devices may not achieve desired delivery rates and actuation times

Method used

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  • Novel implant system for delivering beneficial substances to animals
  • Novel implant system for delivering beneficial substances to animals
  • Novel implant system for delivering beneficial substances to animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] figure 2 is depicting a "hybrid" wax seal comprising 50% Multiwax 180-M and 50% Multiwax X-145a, in varying thicknesses between 1.3mm and 2.5mm, from the inside of an outlet channel with a diameter of 0.4mm and a length of 2.54mm Burst pressure graph. Burst pressure values ​​for these 1.3mm thick seals are always around 1.6kg / cm 2 .

[0036] So an outlet channel with a diameter of 0.4mm and a length of 2.5mm, and a seal 1.3mm thick, to achieve about 1.6kg / cm 2 Internal pressure can rupture the seal.

Embodiment 2

[0038] figure 1 A graph showing the effect on water diffusion using outlet channels of different diameters and a length of 2.5 mm. Observation results of each device showed that in all devices having channels with a diameter of 1.3 mm, the beneficial substance in the formulation turned white due to the incorporation of a small amount of water. In all devices with an exit channel diameter of about 0.4mm, the beneficial substance remained transparent.

[0039] Thus, an outlet pore diameter of 0.4 mm allows beneficial substances to be expelled outwardly from the compartment with sufficient volumetric flow rate to substantially prevent diffusion of external liquid back into the compartment.

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Abstract

The invention relates to a beneficial substance (e.g., drug) delivery system, such as an implantable osmotically driven delivery system, more particularly to a device for protecting a liquid-sensitive beneficial substance and delivering the liquid-sensitive beneficial substance to an external environment, and belongs to the technical field of pharmaceutical equipment. The invention discloses a delivery system. The delivery system is used for delivering a liquid-sensitive benefit substance, such as a growth hormone, or analogs thereof, or derivatives thereof, into the animal body, such as a cattle. The delivery system comprises a wall surrounding an interior compartment, wherein the wall comprises two parts, a first part which restricts penetration of liquid into the system and a second part which allows penetration of the liquid into the system. The system provides an outlet channel for delivering beneficial substances from the interior compartment into the animal body. The outlet channel is sealed with a wax seal which is discharged from the channel when the internal pressure of the device reaches a predetermined "rupture" pressure.

Description

technical field [0001] The present invention relates to a beneficial agent (e.g., drug) delivery system, such as an implantable osmotically driven delivery system, and more particularly, the present invention relates to devices for the protection and delivery of liquid-sensitive beneficial agents to the external environment, It belongs to the technical field of pharmaceutical equipment. Background technique [0002] Devices for delivering beneficial substances into the environment of use of biological fluids are known from the prior art. For example, US Patent Nos. 5,137,727; 5,174,999; and 5,238,687. [0003] These devices include a housing comprising a liquid impermeable first partial wall and a liquid permeable second partial wall. The beneficial substance is enclosed within the walls of the first portion and the expandable driver is enclosed within the walls of the second portion. A sliding piston separates the beneficial substance from the expandable driver. An outl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61M37/00
CPCA61M31/002A61M37/00A61M2205/0238A61M2205/04
Inventor 熊伟弘
Owner 江苏集萃新型药物制剂技术研究所有限公司