Method for measuring displacement of quasi-sphere cell in height direction in lens-free imaging system

An imaging system and height-oriented technology, applied in the field of medical image analysis, can solve problems such as unfavorable image analysis and affecting the imaging effect of the lensless imaging system, and achieve high real-time performance and simple operation

Pending Publication Date: 2021-05-11
XIAN UNIV OF TECH
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Problems solved by technology

The uncertainty of the distance from the cell to the imaging surface will seriously affect the imaging effect of the lensless imaging system, which is not conducive to further analysis of the image

Method used

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  • Method for measuring displacement of quasi-sphere cell in height direction in lens-free imaging system
  • Method for measuring displacement of quasi-sphere cell in height direction in lens-free imaging system
  • Method for measuring displacement of quasi-sphere cell in height direction in lens-free imaging system

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Embodiment Construction

[0041]The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0042]According to a non-lens cell height displacement measurement method, a diffraction image of a quasi-ball cell is collected by microfluidic chips and a non-lens-free imaging system, and the high direction displacement of the test ball cells in microfluidic control Perform measurement. No lens imaging system, such asfigure 1As shown, including the light shielding plate 12, the light source 8, the convex lens 10, the microfluidic chip 13, and the CMOS image sensor 14, the light source 8 is a point source, and the light source 8 is transmitted through the micropores 9, and the convex lens 10 refers to a parallel light. 11. Parallel light 11 is irradiated on the microfluidic chip 13, and the microfluidic chip 13 is in the standard biological sample, and placed on the CMOS image sensor 14, the CMOS image sensor 14 acquires a diffraction image to be teste...

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Abstract

The invention discloses a method for measuring displacement of quasi-sphere cell in height direction in lens-free imaging system, and the method comprises the steps: building a Fresnel diffraction model according to the characteristics of a lensless imaging system, and building a quasi-sphere cell height direction displacement measurement model of the lensless imaging system; obtaining a distance from the diffraction ring of the quasi-sphere cell to the real cell boundary through the diffraction image of the quasi-sphere cell in the biological cell sample to be measured, and substituting the distance into the measurement model to obtain the displacement of the quasi-sphere cell in the height direction. The method can solve the problem that the displacement of the quasi-sphere cells in the micro-fluidic chip in the height direction cannot be accurately measured, is very suitable for POTC combining the micro-fluidic chip and lens-free imaging, is simple to operate and high in real-time performance, and has very important significance on biological cell detection combining a lens-free imaging system and micro-fluidic.

Description

Technical field[0001]The present invention belongs to the technical field of medical image analysis, and involves a highly displacement measurement method in the high direction of the betting cells in the non-lens imaging system.Background technique[0002]Biological cell detection and analysis is an indispensable means of medical research, disease diagnosis. R & D for cell testing equipment and methods is an important force to promote biomedical research, disease diagnosis technology. Among them, the detection and analysis of the surgical cells have an important position.[0003]Traditional biological cell detection is mainly divided into two kinds, one is an artificial method, using an optical microscope for cell detection; the other is a cellular detection by flow cytometry. However, there are high volumes of testing equipment, expensive, and high prices. In recent years, low-cost, portable, user-friendly, and simple real-time detection, POINT-OF-Care Testing, POCTs have received mor...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/10G01N15/14G01B11/02
CPCG01N15/10G01N15/1434G01B11/02G01N2015/1006G01N2015/144G01N2015/1454
Inventor 李建伟吴银峰余宁梅戴力
Owner XIAN UNIV OF TECH
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