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Traditional Chinese medicine compound preparation for treating novel coronavirus infection

A composition and technology of honeysuckle, applied in antiviral agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of lagging research and development of effective therapeutic drugs and virus vaccines, and lack of targeted treatment measures

Inactive Publication Date: 2021-05-14
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the situation and scale of the SARS-CoV-2 epidemic is developing rapidly, and clinically critically ill patients are progressing rapidly, while research on SARS-CoV-2 infection has just started, and the development of effective therapeutic drugs and virus vaccines is lagging far behind. Sexual therapeutic measures, there is an urgent need to find and develop new treatments and drugs

Method used

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  • Traditional Chinese medicine compound preparation for treating novel coronavirus infection
  • Traditional Chinese medicine compound preparation for treating novel coronavirus infection
  • Traditional Chinese medicine compound preparation for treating novel coronavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042](1) Take 300 grams of honeysuckle, 300 grams of forsythia, 150 grams of mulberry leaves, 100 grams of chrysanthemum, 100 grams of salvia miltiorrhiza, 100 grams of paeonol, 150 grams of madder, 150 grams of scrophulariaceae and 150 grams of white peony, soak for 30 minutes first, Decoct twice at 100°C, add 15000 ml of water each time, decoct for 1 hour each time, filter and combine the medicinal solution, concentrate and dry under reduced pressure at 0.08MPa (RE-2000B rotary evaporator, Shanghai Yarong Biochemical Instrument Factory; DZF- 6053 type vacuum drying oven, Shanghai Yiheng Equipment Co., Ltd.) to obtain 386 grams of Chinese medicine extract.

[0043] (2) Get 380g of the Chinese medicine extract of step (1), add 114g starch (Shandong Pingju Biotechnology Co., Ltd.), 114g dextrin (Shandong Liaocheng Luxi Pharmaceutical Excipient Co., Ltd.) and 7.6g of magnesium stearate (Anhui Shanhe Pharmaceutical Excipients Co., Ltd.) was fully mixed, granulated with 85% ethan...

Embodiment 2

[0045] (1) Take 450 grams of honeysuckle, 450 grams of forsythia, 200 grams of mulberry leaves, 150 grams of chrysanthemum, 200 grams of salvia miltiorrhiza, 200 grams of paeonol, 200 grams of madder, 200 grams of scrophulariaceae and 200 grams of white peony, soak for 30 minutes, 100 decoct twice at ℃, add 24500 ml of water each time, decoct for 1 hour each time, filter and combine the liquid medicine, concentrate and dry under reduced pressure at 0.08MPa (RE-2000B rotary evaporator, Shanghai Yarong Biochemical Instrument Factory; DZF-6053 Type vacuum drying oven, Shanghai Yiheng Equipment Co., Ltd.) obtains 764 grams of Chinese medicine extract;

[0046] (2) Get the Chinese medicine extract 760g of step (1), add 240g dextrin (Shandong Liaocheng Luxi Pharmaceutical Excipient Co., Ltd.) 240g sucrose (Nanjing Tongying Biotechnology Co., Ltd.) and mix evenly, with 20% of the total amount mixed 90% ethanol (Beijing Chemical Plant) solution + 3% povidone (Shaanxi Aoke Chemical Co....

Embodiment 3

[0048] For patients diagnosed with novel coronavirus infection, give the granules of embodiment 2, orally, 2 times a day, each 1 bag (equivalent to 30 grams of honeysuckle, 30 grams of forsythia, 15 grams of mulberry leaves, 10 grams of chrysanthemums) , 10 grams of Danshen, 10 grams of paeonol, 15 grams of madder, 15 grams of Scrophulariae and 15 grams of white peony root), taking 14 days as a course of treatment (ethical approval number: 2020001D).

[0049] The randomized controlled trial study of our prescription combined with western medicine conventional treatment has completed the clinical observation of 8 cases, 4 cases of the application composition combined with western medicine group, and 4 cases of western medicine control group. The composition of the present application is combined with western medicine and the traditional Chinese medicine granules of embodiment 2 are added to the basic treatment of western medicine at the same time, and the western medicine contro...

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Abstract

The invention discloses a composition for viral infection. The composition is prepared from the following medicinal materials: honeysuckle, fructus forsythiae, folium mori, chrysanthemum, radix salviae miltiorrhizae, cortex moutan, radix rubiae, radix scrophulariae and radix paeoniae alba. The composition has the effects of clearing heat, promoting blood circulation and dredging collaterals, has an improvement effect on symptoms and indexes of patients with basic diseases of novel coronavirus pneumonia in the middle and later stages of the illness state, delays the disease progress and controls the illness state development.

Description

technical field [0001] The application relates to a compound traditional Chinese medicine preparation for treating novel coronavirus infection, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Novel coronavirus pneumonia refers to pneumonia caused by a new type of coronavirus (Coronavirus, CoV), namely SARS-CoV-2 infection, and is an acute respiratory infectious disease caused by SARS-CoV-2 infection. The World Health Organization declared the outbreak a public health emergency of international concern. However, the situation and scale of the SARS-CoV-2 epidemic is developing rapidly, and clinically critically ill patients are progressing rapidly, while research on SARS-CoV-2 infection has just started, and the development of effective therapeutic drugs and virus vaccines is lagging far behind. There is an urgent need to find and develop new treatments and drugs. Traditional Chinese medicine has played a unique role in the...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P31/14A61P29/00A61P11/00
CPCA61K36/355A61K36/634A61K36/605A61K36/287A61K36/537A61K36/71A61K36/65A61K36/74A61K36/808A61P31/14A61P29/00A61P11/00A61K2300/00
Inventor 王伽伯王睿林景婧牛明王仲霞余思邈柏兆方张萍赵旭郭玉明徐广肖小河
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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