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Diclofenac sodium abdominal navel patch suitable for anorectal postoperative analgesia and preparation method thereof

A technique for diclofenac sodium and anorectal surgery, applied in the field of medicine, can solve the problems of strong gastrointestinal irritation, low bioavailability, short-lived analgesic effect, etc. for quick absorption

Pending Publication Date: 2021-06-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the current lack of ideal analgesic measures or drugs for anorectal surgery, the present invention provides a diclofenac sodium umbilical patch suitable for analgesia after anorectal surgery. After analgesia, it can overcome the shortcomings of oral non-steroidal analgesics such as strong gastrointestinal irritation, low bioavailability, slow onset, short-term analgesic effect, etc., and can also avoid intravenous infusion of fentanyl, Nausea and vomiting, urinary retention, skin itching, respiratory depression and other adverse reactions of morphine analgesics can solve the severe pain caused by the stimulation of anorectal postoperative wound when diclofenac sodium suppository is inserted, which has good clinical application value and significance

Method used

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  • Diclofenac sodium abdominal navel patch suitable for anorectal postoperative analgesia and preparation method thereof
  • Diclofenac sodium abdominal navel patch suitable for anorectal postoperative analgesia and preparation method thereof
  • Diclofenac sodium abdominal navel patch suitable for anorectal postoperative analgesia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of Diclofenac Sodium Abdominal Umbilical Patch

[0046] (1) Cut the medical elastic sponge into a hemispherical shape that can match the navel of the human body, put it into the coating solution (the coating solution is 20% ethyl cellulose ethanol solution) for 3 minutes, take it out, and place it at 42°C After drying, a sponge hemisphere wrapped with a non-porous ethylcellulose film was obtained, which was bonded to the middle position of the backing layer.

[0047] (2) prepare diclofenac sodium gel, concrete composition and percentage by weight thereof are: diclofenac sodium 0.8%, carbomer 0.8%, propylene glycol 10%, triethanolamine 0.8%, surplus is distilled water, preparation step: diclofenac sodium is dissolved in Boil in a mixed solution of propylene glycol and distilled water, sprinkle carbomer when cooled to 55°C, swell, add triethanolamine to neutralize, stir to form a gel, and spread it evenly on the medical elastic sponge hemisphere in the rapi...

Embodiment 2

[0058] 1. Preparation of Diclofenac Sodium Abdominal Umbilical Patch

[0059] (1) Use a mold to cut the medical elastic sponge into a hemisphere that can match the navel of the human body, put it into the coating solution (the coating solution is a 95% ethanol solution of ethyl cellulose) for 3 minutes, take it out, and place it at 45 Dry at ℃ to obtain a medical elastic sponge hemisphere with a non-porous ethylcellulose film wrapped on the surface, which is bonded to the middle position of the backing layer.

[0060] (2) prepare diclofenac sodium gel, concrete composition and percentage by weight thereof are: diclofenac sodium 1.2%, carbomer 1.0%, propylene glycol 12%, triethanolamine 1.0%, surplus is distilled water, preparation step: diclofenac sodium is dissolved in Boil in a mixed solution of propylene glycol and distilled water, sprinkle carbomer when cooled to 60°C, swell, add triethanolamine to neutralize, stir to form a gel, and spread it evenly on the medical elastic...

Embodiment 3

[0071] 1. Preparation of Diclofenac Sodium Abdominal Umbilical Patch

[0072] (1) Use a mold to cut the medical elastic sponge into a hemisphere that can match the navel of the human body, put it into the coating solution (the coating solution is a 95% ethanol solution of ethyl cellulose) for 3 minutes, take it out, and place it at 48 Dry at ℃ to obtain a medical elastic sponge hemisphere with a non-porous ethylcellulose film wrapped on the surface, which is bonded to the middle position of the backing layer.

[0073] (2) prepare diclofenac sodium gel, concrete composition and percentage by weight thereof are: diclofenac sodium 1.5%, carbomer 1.2%, propylene glycol 15%, triethanolamine 1.2%, surplus is distilled water, preparation step: diclofenac sodium is dissolved in Boil in a mixed solution of propylene glycol and distilled water, sprinkle carbomer when cooled to 65°C, swell, add triethanolamine to neutralize, stir to form a gel, and spread it evenly on the medical elastic...

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Abstract

The invention discloses a diclofenac sodium abdominal navel patch suitable for anorectal postoperative analgesia, and belongs to the technical field of medicines. The diclofenac sodium abdominal navel patch comprises a backing layer, an abdominal navel patch body and a protective film; the backing layer is covered with the abdominal navel patch body, and the surface of the abdominal navel patch body is covered with the protective film; the abdominal navel patch body sequentially comprises a rapid drug release area, a controlled-speed drug release area and a pasting area from the circle center to the outside, the rapid drug release area comprises a diclofenac sodium gel layer and a medical elastic sponge coated with a nonporous ethyl cellulose membrane, the controlled-speed drug release area comprises a porous ethyl cellulose membrane layer and a diclofenac sodium gel layer, and the pasting area is a pressure-sensitive adhesive. The abdominal navel patch provided by the invention not only overcomes the defects that a diclofenac sodium oral preparation is slow in effect taking, large in gastrointestinal tract side effect and the like, but also avoids severe pain caused by anorectal postoperative wound stimulation when a suppository is stuffed, has the advantages of quick effect taking, long analgesia time, convenience in use and the like, and is particularly suitable for anorectal postoperative analgesia.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a diclofenac sodium abdominal umbilical patch suitable for anorectal postoperative pain relief and a preparation method thereof. Background technique [0002] Surgery is the most effective treatment for anorectal diseases such as anal fistula, anal fissure, and mixed hemorrhoids. The physiological function and anatomical characteristics of the anus determine that the surgical wound can only be open, and the nerve endings in the anal area are densely distributed. etc. will cause severe pain, cause difficulty in defecation, urinary retention and many other complications, which seriously affect postoperative rehabilitation and quality of life of patients. Therefore, safe, effective, economical and appropriate analgesic drugs, dosage forms and routes of administration are very important Patients are especially important. [0003] At present, oral non-steroidal analgesic...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K31/196A61P29/00
CPCA61K9/703A61K9/0014A61K47/38A61K31/196A61P29/00Y02A50/30
Inventor 王咏懿蒋曙光
Owner CHINA PHARM UNIV
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