A clearly developed embolic material and preparation method thereof

Abstract

The invention relates to the field of interventional medicine, in particular to a clearly developed embolic material and a preparation method thereof. The embolic material is composed of a temperature-sensitive polymer solution and a developer; the temperature-sensitive polymer is N-isopropylacrylamide represented by NIP and N-n-propylacrylamide represented by NNP. A monomer, a polymer formed by copolymerization in the range of 75:25 to 50:50 by weight; the degree of polymerization of the temperature-sensitive polymer is 1×10 5 ~2.5×10 5 ; the concentration of the temperature-sensitive polymer solution is 0.0085-0.01g / mL; the developer includes a water-soluble developer. The embolic material of the present invention has a good developing effect, and can realize real-time monitoring of the embolization position and embolization effect during the target treatment process, so that the embolization position is more accurate.

Description

technical field

[0001] The invention relates to the field of interventional medicine, in particular to a clearly developed embolic material and a preparation method thereof. Background technique

[0002] Interventional therapy is one of the most rapidly developing disciplines, and embolization is an important component of interventional therapy. Embolotherapy, called embolotherapy, is the controlled injection of plugs into the supply blood vessels of diseased organs through arterial or intravenous catheters to occlude them and interrupt blood supply in order to control bleeding, treat tumors, and vascular lesions. The purpose of eliminating the function of diseased organs.

[0003] The choice of embolization material determines the quality of embolization treatment. The embolization material with imaging function can realize the real-time monitoring of the embolization position and embolization effect during the target treatment, so that the embolization site is more accur...

Examples

preparation example Construction

[0041] In one embodiment, the preparation method of the temperature-sensitive polymer comprises the following steps:

[0042] (1) Preparation of N-isopropylacrylamide: Isopropylamine and ethyl acetate were charged in the reaction vessel, and the reaction vessel was placed in an ice-water bath for cooling, and propylene was added dropwise to the reaction vessel with a constant pressure dropping funnel The acid chloride, after the dropwise addition, was reacted with ice water for 4 hours, after the reaction was completed, the reaction solution was suction filtered, the filtrate was collected, distilled under reduced pressure, and the fraction was cooled to N-isopropylacrylamide;

[0043] (2) preparation of N-n-propylacrylamide: n-propylamine and toluene are charged in the reaction vessel, and the reaction vessel is placed in an ice-water bath for cooling, and acryloyl chloride is added dropwise to the reaction vessel with a constant pressure dropping funnel, After the dropwise a...

Embodiment 1

[0070] Embodiment 1 of the present invention specifically provides a clearly developed embolization material, the embolization material is composed of a solution of a temperature-sensitive polymer and a developer; the temperature-sensitive polymer is N-isolated by NIP. A polymer obtained by copolymerization of propylacrylamide and N-n-propylacrylamide represented by NNP at a ratio of 75:25 by weight; the degree of polymerization of the temperature-sensitive polymer is 1×10 5 ; The concentration of the solution of the temperature-sensitive polymer is 0.0085 g / mL; the developer includes a water-soluble developer;

[0071] The water-soluble developer is a water-soluble non-ionic developer; the water-soluble non-ionic developer is a mixture of iodixanol and ioversol; the weight ratio of the iodixanol and ioversol is 2:1; The developer also includes iodized oil; the weight of the iodized oil is 8% of the weight of iodixanol; the mass percentage concentration of the developer in the...

Embodiment 2

[0081] Embodiment 2 of the present invention specifically provides a clearly developed embolization material, the embolization material is composed of a solution of a temperature-sensitive polymer and a developer; the temperature-sensitive polymer is N-isolated by NIP. A polymer obtained by copolymerization of propylacrylamide and N-n-propylacrylamide represented by NNP at a weight percentage of 50:50; the degree of polymerization of the temperature-sensitive polymer is 2.5×10 5 ; The concentration of the solution of the temperature-sensitive polymer is 0.01 g / mL; the developer includes a water-soluble developer;

[0082] The water-soluble developer is a water-soluble non-ionic developer; the water-soluble non-ionic developer is a mixture of iodixanol and ioversol; the weight ratio of the iodixanol and ioversol is 2.6:1; The developer also includes iodized oil; the weight of the iodized oil is 15% of the weight of iodixanol; the mass percentage concentration of the developer i...

technical field

[0001] The invention relates to the field of interventional medicine, in particular to a clearly developed embolic material and a preparation method thereof. Background technique

[0002] Interventional therapy is one of the most rapidly developing disciplines, and embolization is an important component of interventional therapy. Embolotherapy, called embolotherapy, is the controlled injection of plugs into the supply blood vessels of diseased organs through arterial or intravenous catheters to occlude them and interrupt blood supply in order to control bleeding, treat tumors, and vascular lesions. The purpose of eliminating the function of diseased organs.

[0003] The choice of embolization material determines the quality of embolization treatment. The embolization material with imaging function can realize the real-time monitoring of the embolization position and embolization effect during the target treatment, so that the embolization site is more accur...

Examples

preparation example Construction

[0041] In one embodiment, the preparation method of the temperature-sensitive polymer comprises the following steps:

[0042] (1) Preparation of N-isopropylacrylamide: Isopropylamine and ethyl acetate were charged in the reaction vessel, and the reaction vessel was placed in an ice-water bath for cooling, and propylene was added dropwise to the reaction vessel with a constant pressure dropping funnel The acid chloride, after the dropwise addition, was reacted with ice water for 4 hours, after the reaction was completed, the reaction solution was suction filtered, the filtrate was collected, distilled under reduced pressure, and the fraction was cooled to N-isopropylacrylamide;

[0043] (2) preparation of N-n-propylacrylamide: n-propylamine and toluene are charged in the reaction vessel, and the reaction vessel is placed in an ice-water bath for cooling, and acryloyl chloride is added dropwise to the reaction vessel with a constant pressure dropping funnel, After the dropwise a...

Embodiment 1

[0070] Embodiment 1 of the present invention specifically provides a clearly developed embolization material, the embolization material is composed of a solution of a temperature-sensitive polymer and a developer; the temperature-sensitive polymer is N-isolated by NIP. A polymer obtained by copolymerization of propylacrylamide and N-n-propylacrylamide represented by NNP at a ratio of 75:25 by weight; the degree of polymerization of the temperature-sensitive polymer is 1×10 5 ; The concentration of the solution of the temperature-sensitive polymer is 0.0085 g / mL; the developer includes a water-soluble developer;

[0071] The water-soluble developer is a water-soluble non-ionic developer; the water-soluble non-ionic developer is a mixture of iodixanol and ioversol; the weight ratio of the iodixanol and ioversol is 2:1; The developer also includes iodized oil; the weight of the iodized oil is 8% of the weight of iodixanol; the mass percentage concentration of the developer in the...

Embodiment 2

[0081] Embodiment 2 of the present invention specifically provides a clearly developed embolization material, the embolization material is composed of a solution of a temperature-sensitive polymer and a developer; the temperature-sensitive polymer is N-isolated by NIP. A polymer obtained by copolymerization of propylacrylamide and N-n-propylacrylamide represented by NNP at a weight percentage of 50:50; the degree of polymerization of the temperature-sensitive polymer is 2.5×10 5 ; The concentration of the solution of the temperature-sensitive polymer is 0.01 g / mL; the developer includes a water-soluble developer;

[0082] The water-soluble developer is a water-soluble non-ionic developer; the water-soluble non-ionic developer is a mixture of iodixanol and ioversol; the weight ratio of the iodixanol and ioversol is 2.6:1; The developer also includes iodized oil; the weight of the iodized oil is 15% of the weight of iodixanol; the mass percentage concentration of the developer i...

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