A kind of rhtsg6-fnⅢ1-c fusion protein and its use in skin care composition and its preparation method

A rhtsg6-fniii1-c, fusion protein technology, applied in the preparation methods of peptides, preparations for skin care, methods based on microorganisms, etc. The problem is to achieve the effect of simple preparation method, less skin allergy and low production cost
CN112876569BActive Publication Date: 2022-05-10WUHU TIANMING BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHU TIANMING BIOTECH CO LTD
Publication Date
2022-05-10

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Abstract

The invention relates to the technical field of cosmetics, and discloses a rhTSG6-FNIII1-C fusion protein, its application in skin care composition and its preparation method. The rhTSG6-FNⅢ1-C fusion protein is prepared by genetic engineering prokaryotic expression technology, and the specific method includes: codon optimization of the gene sequence of SEQ ID NO:1; construction of a recombinant expression vector and transformation; induction of recombinant Escherichia coli and expression; the expression product is separated and purified to prepare rhTSG6‑FNⅢ1‑C fusion protein. The skin care composition of the present invention has multiple dosage forms, such as aqueous solution, ointment, suppository, cream and facial mask, and has good skin care effects such as improving skin wrinkles and maintaining skin elasticity, reducing skin inflammation and allergy risks, and so on. It is used in the field of functional cosmetics or medical cosmetology.
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Description

technical field

[0001] The invention relates to a recombinant human tumor necrosis factor α-stimulated gene-6-fibronectin Ⅲ 1-C (recombination human tumor necrosis factor α-stimulated gene-6-fibronectin Ⅲ 1-C, rhTSG6- FNⅢ1-C) fusion protein, and a skin care composition for improving skin wrinkles, maintaining skin elasticity, and reducing the risk of skin inflammation and allergies. It contains the same active ingredients. Background technique

[0002] Human skin is composed of epidermis, dermis, subcutaneous tissue and skin appendages, and has functions such as protection, temperature regulation, metabolism and sensation. The state of the epidermis and dermis is closely related to the state of the skin, and the homeostasis of the cellular environment composed of cells and extracellular matrix is ​​related to the state of the skin.

[0003] Fibronectin (FN) is a high molecular weight (about 440kDa) dimeric glycoprotein of the extracellular matrix, which binds to the integr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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