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Synergistic pesticidal compositions for delivery of pesticidal active ingredients and methods therefor

A technology of pesticide composition and active ingredients, applied in the field of synergistic pesticide composition for delivery of pesticide active ingredients, enhancing the activity and efficacy of pesticide active ingredients in the pesticide composition, and can solve rare and complex synergistic combinations and other problems

Pending Publication Date: 2021-07-23
0903608 B C LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, large-scale experimental drug combination studies conducted in non-agricultural fields found that synergistic combinations of drug pairs are extremely complex and rare, with only a 4%-10% probability of finding synergistic drug pairs [Yin et al., PLOS 9:e93960 (2014 ); Cokol et al., Mol. Systems Biol. [Molecular Systems Biology]. 7:544 (2011)]

Method used

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  • Synergistic pesticidal compositions for delivery of pesticidal active ingredients and methods therefor
  • Synergistic pesticidal compositions for delivery of pesticidal active ingredients and methods therefor
  • Synergistic pesticidal compositions for delivery of pesticidal active ingredients and methods therefor

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0171] Example 1: Growth inhibition of Fusarium oxysporum by pyraclostrobin in combination with various exemplary C4-C10 unsaturated fatty acids (or agriculturally acceptable salts thereof)

[0172] Sample Preparation:

[0173] Dissolve 10 mg pyraclostrobin (available from Santa Cruz Biotechnology, Dallas, Texas, stock #229020) in 10 mL dimethyl sulfoxide (DMSO), and dissolve the resulting solution in DMSO Diluted 2-fold in medium to obtain a concentration of 0.5 mg / mL. This solution was diluted 10-fold in potato dextrose broth (PDB) to give a concentration of 0.05 mg / mL in 10% DMSO / 90% PDB. The solubility of pyraclostrobin in 10% DMSO / 90% PDB was determined to be 0.0154 mg / mL by high performance liquid chromatography (HPLC).

[0174] A solution of (2E,4E)-2,4-hexadienoic acid potassium salt was prepared by dissolving 2 g of (2E,4E)-2,4-hexadienoic acid potassium salt in 20 mL of PDB, which was further diluted by serial dilution in PDB. (2E,4E)-2,4-Hexadienoic acid (available...

example 2

[0179] Example 2: Growth inhibition of Fusarium oxysporum by fludioxonil in combination with various exemplary unsaturated fatty acids (or agriculturally acceptable salts thereof)

[0180] Sample Preparation:

[0181] Dissolve 20 mg of fludioxonil (available from Shanghai Terppon Chemical Co. Ltd., Shanghai, China) in 10 mL of dimethyl sulfoxide (DMSO), and dilute the resulting solution 2-fold in DMSO to give a concentration of 1 mg / mL . This solution was diluted 10-fold in potato dextrose broth (PDB) to give a concentration of 0.1 mg / mL in 10% DMSO / 90% PDB. The solubility of fludioxonil in 10% DMSO / 90% PDB was determined to be 0.0154 mg / mL using HPLC.

[0182] A solution of (2E,4E)-2,4-hexadienoic acid potassium salt was prepared by dissolving 2 g of (2E,4E)-2,4-hexadienoic acid potassium salt in 20 mL of PDB, which was further diluted by serial dilution in PDB. (2E,4E)-2,4-Hexadienoic acid (available from Sigma-Aldrich, #W342904 ) to give a 2 mg / mL solution of (2E,4E)-2,...

example 3

[0188] Example 3: Growth inhibition of Fusarium oxysporum by fludioxonil in combination with various exemplary unsaturated fatty acids:

[0189] Sample Preparation:

[0190] Dissolve 20 mg of fludioxonil (available from Shanghai Terppon Chemical Co. Ltd., Shanghai, China) in 10 mL of dimethyl sulfoxide (DMSO), and dilute the resulting solution 2-fold in DMSO to give a concentration of 1 mg / mL . This solution was diluted 10-fold in potato dextrose broth (PDB) to give a concentration of 0.1 mg / mL in 10% DMSO / 90% PDB. The solubility of fludioxonil in 10% DMSO / 90% PDB was determined to be 0.0154 mg / mL using HPLC.

[0191] For 3-octenoic acid (available from Sigma-Aldrich, stock #CDS000466), trans-2-octenoic acid (available from Sigma-Aldrich), 9-decenoic acid (available from Sigma-Aldrich, # W366005), 3-decenoic acid (available from Sigma-Aldrich, stock #CDS000299) and trans-2-decenoic acid (available from TCI America, stock #D0098), through 25uL of each Stock solutions of var...

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PUM

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Abstract

Compositions and methods for increasing the efficacy of pesticidal compositions are described herein, including synergistic pesticidal compositions comprising: benzovindiflupyr, bixafen, boscalid, cyproconazole, fenpicoxamid, fenpyrazimine, florylpicoxamid, flutriafol, fluxapyroxad, isopyrazam, isotianil, kresoxim-methyl, metrafenone, oxathiapiprolin, penflufen, penthiopyrad, picoxystrobin, prothioconazole, pydiflumetofen, revysol, sedaxane, trifloxystrobin, pyraclostrobin, azoxystrobin, chlorothalonil, cyprodinil, metalaxyl, epoxiconazole, propiconazole, difenoconazole, fludioxonil, mancozeb, tebuconazole, valifenalate, in combination with a C4-C10 saturated or unsaturated aliphatic acid and methods for delivery of pesticidal active ingredients. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of fungicides. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of nematicides. Some pesticidal compositions and methods as described are directed to compositions and methods for increasing the efficacy of insecticides. Methods for enhancing the activity pesticidal active ingredients in pesticidal compositions in use are also described.

Description

[0001] Cross-references to related applications [0002] This application claims U.S. Provisional Patent Application Nos. 62 / 737907 filed on September 27, 2018, 62 / 737914 filed on September 27, 2018, 62 / 829512 filed on April 4, 2019, and 62 / 829512 filed on April 4, 2019. No. 62 / 829525 filed on the same date, entitled "SYNERGISTIC PESTICIDAL COMPOSITIONS AND METHODS FORDELIVERY OF ACTIVE INGREDIENTS", which are incorporated by reference in their entirety. Enter this article. Technical field [0003] One embodiment of the present invention relates to compositions and methods for improving the efficacy of pesticide compositions. More specifically, some embodiments relate to synergistic pesticide compositions and methods for delivering pesticide active ingredients. Some embodiments of the present invention relate to compositions and methods for increasing the efficacy of fungicides. Some embodiments of the present invention relate to compositions and methods for increasing the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/06A01N37/02A01N61/00
CPCA01N37/06A01N37/02A01N37/36A01N37/34A01N37/46A01N37/50A01N43/22A01N43/26A01N43/36A01N43/40A01N43/54A01N43/56A01N43/653A01N43/80A01N43/90A01N45/02A01N47/14A01N47/24A01N49/00A01N59/16A01N65/08A01N65/16A01N65/20A01N65/22A01N65/24A01N65/26A01N65/28A01N65/34A01N65/42A01N65/44A01N61/00A01P3/00A01N35/02A01N37/30A01N47/12
Inventor 卡兰·曼哈斯安尼特·罗泽克何月华卡斯坦特那奥斯·兰布睿那迪斯裴乐灵萨迪克·肖卡蒂安
Owner 0903608 B C LTD
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