The invention belongs to the field of pesticides and herbicides, and particularly discloses a herbicide composition containing clopyralid, which is applied to forestry nursery and used for preventing and treating weeds of the grass family, broad leaves and sedge family. The herbicide composition comprises the following compounds as active components: 1, a compound A, namely clopyralid; 2, an enhancing active component B of a herbicide mixture, namely oxyfluorfen, wherein the weight proportion of clopyralid to oxyfluorfen is (1:40) to (30:1). According to the herbicide composition disclosed by the invention, by the mutual preparation of the components, the application amount of each single agent can be reduced, the production cost can be reduced, and meanwhile the herbicide controlling spectrum can be widened, and the drug resistance of plants can be slowed down. The herbicide composition can be widely applied to various nursery fields for preventing and removing weeds of grass including barnyard grass, green bristlegrass, amur foxtail, crab grass, bluegrass, moleplant seed and the like, as well as difficult prevention broad-leaf weeds including cirsium setosum, sonchus brachyotus, welted thistle, vicia sativa, polygonum aviculare and the like, and has the characteristics of wide herbicide controlling spectrum, safety and high efficiency to crops.