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Agent containing 4-phenylbutyrate, for preventing or treating presbyopia

A technology of phenylbutyric acid and preventive agent, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, aerosol delivery, etc., and can solve the problems of not reporting the relationship of 4-phenylbutyric acid , to achieve the effect of improving the elasticity

Pending Publication Date: 2021-07-23
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature reporting the relationship between 4-phenylbutyric acid and presbyopia treatment

Method used

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  • Agent containing 4-phenylbutyrate, for preventing or treating presbyopia
  • Agent containing 4-phenylbutyrate, for preventing or treating presbyopia
  • Agent containing 4-phenylbutyrate, for preventing or treating presbyopia

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Experimental program
Comparison scheme
Effect test

Embodiment

[0103] The results of the pharmacological tests are shown below, but these results are for better understanding of the present invention and do not limit the scope of the present invention.

[0104] [Pharmacological Test 1]

[0105] The effect of choline lipoate (EV06) on the elasticity of the lens was confirmed. The evaluation test was performed with reference to the method described in InvestOphthalmolVis Sci, 57, 2851-2863, 2016. EV06 is a compound represented by the following formula (2).

[0106] [Chemical formula 2]

[0107]

[0108] (Preparation of test samples)

[0109] 1) Preparation of the substrate

[0110] Prepared containing 0.1% (w / v) ethyl pyruvate, 0.269% (w / v) sodium hydrogen phosphate monohydrate (NaH 2 PO 4 H 2 O), 0.433% (w / v) disodium hydrogen phosphate (Na 2 HPO 4 ), 0.2% (w / v) hydroxypropyl methylcellulose, 0.5% (w / v) NaCl.

[0111] 2) Preparation of EV06 samples

[0112] Matrix was added to EV06 and sonicated to prepare a 5% (w / v) suspensi...

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PUM

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Abstract

The present disclosure provides an agent that is for preventing or treating eye diseases such as presbyopia and that contains, as an active ingredient, 4-phenylbutyrate or an ester thereof, or a pharmaceutically acceptable salt thereof.

Description

technical field [0001] The present invention relates to a therapeutic or preventive agent for presbyopia containing 4-phenylbutyric acid or its ester or its pharmaceutically acceptable salt as an active ingredient. Background technique [0002] Presbyopia is one of the aging phenomena of the eyes starting from about age 40, and is also commonly known as presbyopia. According to Non-Patent Document 1, it is defined as a disease of age-related loss of accommodation (Age-Related Loss of Accommodation). . In order to focus on seeing near and far objects, light entering the eye must be properly refracted when passing through the lens. Therefore, the eye has the function of adjusting the thickness of the lens by contracting the ciliary muscle located near the lens. The ocular tissues involved in the far-near accommodation response include the lens, ciliary zonules, lens capsule, and ciliary muscle. However, when the function of the ciliary muscle decreases due to aging, or the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P27/10A61K9/06A61K9/08A61K47/02A61K47/14A61K47/38
CPCA61P27/10A61K47/02A61K31/192A61K47/14A61K47/38A61K9/06A61K9/08A61K9/0048A61P27/02
Inventor 加藤雅智小田知子野崎健介
Owner SANTEN PHARMA CO LTD
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