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A kind of Echinococcus granulosus antigen and its application

A technology for Echinococcus granulosus and adult worms, applied in the field of immunology, can solve the problems of complex multicellular parasite antigens, incomplete elucidation of host interaction mechanism, and no final host vaccine.

Active Publication Date: 2022-08-09
XINJIANG ACADEMY OF AGRI & RECLAMATION SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that E. granulosos is complex as a multicellular parasite antigen, and the mechanism of interaction with the host has not been fully elucidated, and there is currently no final host vaccine available for commercialization

Method used

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  • A kind of Echinococcus granulosus antigen and its application
  • A kind of Echinococcus granulosus antigen and its application
  • A kind of Echinococcus granulosus antigen and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 Animal test immunization test

[0093] 1. Materials

[0094] 1.1 Test dogs and protoscoria

[0095] 1.1.1 Test dogs

[0096] Fifteen female beagle dogs aged 6-8 months were randomly divided into 5 groups, including: ①PBS group, ②Quil A group, ③TSP1 group, ④TSP11 group, ⑤Mixed immunization group (TSP1+TSP11), 3 dogs in each group, fed daily Feed dog food and purified water and conduct environmental disinfection, and bury the excrement after harmless treatment.

[0097] 1.1.2 Protoscoria

[0098] The sheep livers with Echinococcus granulosus were collected from local designated slaughterhouses, cleaned and moved to an aseptically treated ultra-clean bench. The surface of the cyst was gently wiped with an alcohol cotton ball, and the bag was repeatedly aspirated with a disposable syringe. To remove cyst fluid, add the aspirated cyst fluid into a 50 mL EP tube that has been sterilized by autoclaving, and let it stand for echinococcus precipitation to discard t...

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Abstract

The invention discloses an Echinococcus granulosus antigen and an application thereof, belonging to the technical field of immunology. The antigen includes any one of the following proteins: 1) Echinococcus granulosus TSP1 protein as shown in SEQ ID NO: 1; 2) Echinococcus granulosus TSP11 protein as shown in SEQ ID NO: 2; 3) A protein combination constructed from the E. granulosus TSP1 protein shown in SEQ ID NO: 1 and the E. granulosus TSP11 protein shown in SEQ ID NO: 2. The invention uses Echinococcus granulosus TSP1 protein, TSP11 protein and the protein combination of TSP1 and TSP11 cocktail as the target antigen, and the prepared canine anti-Echinococcus granulosus vaccine can obviously inhibit Echinococcus granulosus disease, which is Provide technical support for scientific and effective prevention and control of Echinococcus granulosus.

Description

technical field [0001] The invention relates to the technical field of immunology, and relates to an Echinococcus granulosus antigen and its application. Background technique [0002] Echinococcus granulosus, also known as Cystic echinococcosis (CE), is caused by Echinococcus granulosus (E. granulosus) larvae parasitic on cattle, sheep, pigs and other animals and humans. A zoonotic parasitic disease of the liver, lungs, and other organs. Humans contract the disease from ingestion of parasite eggs contained in contaminated food, water or soil, or from direct contact with animal hosts. The disease is widespread and distributed worldwide. WHO lists it as one of the neglected tropical diseases (Neglected Tropical Diseases, NTD). Hydatid disease seriously endangers human health and the development of animal husbandry. Due to the widespread prevalence, abundant hosts, and complex geographical ecology, E. granulosus may have different plant types in my country. Because infection...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/435A61K39/00A61P33/10
CPCC07K14/43554A61K39/0003A61P33/10A61K2039/552Y02A50/30
Inventor 王正荣薄新文孟季蒙赵鹏鹏张艳艳孙艳
Owner XINJIANG ACADEMY OF AGRI & RECLAMATION SCI