Method, device and equipment for evaluating immunity level and storage medium

An immune and level technology, applied in the field of immunization, can solve the problems of rough evaluation of immune detection methods, lack of comprehensiveness, sensitivity and accuracy, and achieve the effect of efficient evaluation and improvement of accuracy.

Pending Publication Date: 2021-08-10
SHANGHAI BIOTECAN PHARMA +2
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  • Claims
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Problems solved by technology

However, its accuracy needs to be further improved
[0005] Therefore, most of the existing immune detection methods can only be roughly evaluated, lacking comprehensiveness, sensitivity and accuracy, and it is necessary to establish a new method for immunity evaluation

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  • Method, device and equipment for evaluating immunity level and storage medium
  • Method, device and equipment for evaluating immunity level and storage medium
  • Method, device and equipment for evaluating immunity level and storage medium

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Embodiment Construction

[0051] In order to further illustrate the technical means and effects adopted by the present invention, the present invention will be further described below in conjunction with the embodiments and accompanying drawings. It should be understood that the specific implementation manners described here are only used to explain the present invention, rather than to limit the present invention.

[0052]If no specific technique or condition is indicated in the examples, the technique or condition described in the literature in the field or the product specification is used. The reagents or instruments used without the manufacturer's indication are conventional products that can be purchased through regular channels.

[0053] In the present invention, there is provided a method for assessing immunity level for the purpose of non-disease diagnosis, the method as figure 1 shown, including the following steps:

[0054] S1. Compare the sequencing data with the data in the public databa...

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Abstract

The invention provides a method, device and equipment for evaluating the immunity level and a storage medium. The method comprises the following steps: (1) collecting sequencing data of a B cell antigen receptor variable region and / or a T cell antigen receptor variable region of a lymphocyte sample, comparing the sequencing data with data in a public database, and calculating a D value; (2) distinguishing healthy samples and sub-healthy samples according to the distribution diagram of the D values, fitting the D values of the healthy samples by adopting multiple Gaussian distribution, and determining a standard D value; (3) fitting the D values of the sub-health sample and the disease sample by adopting a Gaussian distribution function to obtain a Gaussian distribution function A and a Gaussian distribution function B; (4) evaluating the immunity level of the unknown sample according to the standard D value, the Gaussian distribution function A and the Gaussian distribution function B. According to the method, the sequencing result is analyzed and subjected to multiple Gaussian distribution fitting, and the effect of accurately, comprehensively and efficiently evaluating the immunity of the sample is achieved.

Description

technical field [0001] The invention belongs to the technical field of immunization, and relates to a method, device, equipment and storage medium for evaluating immunity level. Background technique [0002] At present, the clinically applied immune function analysis methods mainly include immune five items, blood routine and lymphocyte subset analysis. Among them, the five items of immunity use one-way immunodiffusion method, enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), immunofixation electrophoresis or immunoturbidimetry to detect IgG, IgA, IgM, complement C3 and C4 in blood Blood routine uses cell counting to analyze the number of white blood cells in peripheral blood to determine whether there is an inflammatory response in the body; lymphocyte subset analysis uses flow cytometry or PCR technology to analyze the number of different white blood cell subsets in peripheral blood and relative proportions. [0003] However, these methods have drawbacks...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/20
CPCG16H50/20G16H50/30
Inventor 楼敬伟高军晖
Owner SHANGHAI BIOTECAN PHARMA
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