Pharmaceutical composition of forskolin/iforeskolin and pentacyclic triterpenes and application thereof
A technology of pentacyclic triterpenoids and compositions, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of orderly arrangement of liver cells, improvement of liver function, and reduction of fat accumulation
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Embodiment 1
[0044] Example 1: The therapeutic effect of the pharmaceutical composition of the present invention on high-fat diet-induced obesity model and fatty liver model.
[0045] To compare the therapeutic effects of forskolin / isoforskolin combined with pentacyclic triterpenoids and alone on high-fat diet-induced obesity and fatty liver models to verify the synergistic treatment of the composition of the present invention Effect.
[0046] 1. Establishment of non-alcoholic fatty liver model mice
[0047] After 160 SPF grade 8-9 weeks old male C57 mice were adaptively reared for one week, 140 mice with uniform body weight and obesity were selected and divided into 14 groups on average, 10 mice in each group, which were model group (M group) , forskolin group (F group), isforskolin group (IF group), asiatic acid group (AA group), madecassoside group (AS group), oleanolic acid group (OA group) , betulinic acid group (BA group), forskolin+asiatic acid combination group (F+AA group), fors...
Embodiment 2
[0072] Embodiment 2 pharmaceutical composition of the present invention to CCl 4 Therapeutic effects in an induced model of chronic liver fibrosis compared with forskolin combined with pentacyclic triterpenoids and alone on CCl 4 The therapeutic effect of the induced chronic liver fibrosis model mice to verify the synergistic therapeutic effect of the composition of the present invention.
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