Pharmaceutical composition of forskolin/iforeskolin and pentacyclic triterpenes and application thereof

A technology of pentacyclic triterpenoids and compositions, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of orderly arrangement of liver cells, improvement of liver function, and reduction of fat accumulation
CN113244405BActive Publication Date: 2022-06-21CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2022-06-21

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Abstract

The present invention relates to a pharmaceutical composition, which comprises two components, the first component is selected from forskolin, isofaskolin or pharmaceutically acceptable salts thereof; the second component is selected from five Cyclic triterpenoids or pharmaceutically acceptable salts thereof. The pharmaceutical composition of the present invention uses forskolin / iforeskolin and pentacyclic triterpenoids in combination, compared with using the two components alone, it can prevent and treat metabolic, fibrosis, and liver diseases It has a significant synergistic effect, so it has broad medicinal prospects in the treatment, prevention, and improvement of diseases such as obesity, non-alcoholic fatty liver, liver injury, and liver fibrosis.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition comprising forskolin / isoforskolin and pentacyclic triterpenoids and a medicine for preventing, improving or treating metabolic diseases, fibrotic diseases and liver diseases. use in. Background technique

[0002] With the improvement of economic level, people's diet structure has undergone great changes, the intake of lipids has increased, and the number of obese people has gradually expanded. The World Health Organization (WHO) defines people with a body mass index (BMI) ≥ 25 as overweight. It leads to the occurrence of various metabolic diseases, such as diabetes, hypertension, hyperlipidemia, fatty liver and so on. Non-alcoholic fatty liver disease (NAFLD) is a type of disease characterized by lipid accumulation and degeneration in liver cells. The pathological section is mainly characterized by a significant increase in lipid droplets in liver cells, and in...

Claims

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