Preparation method and application of flavonoid glycoside monomer isovitexin of Hydrocotyle sibthorpioides

A technology of cilantro flavonoid glycosides and isovitexin, which is applied in the field of preparation of isovitexin, a flavonoid glycoside monomer of coriander, can solve the problems that has not yet been found , to achieve the effect of clear and efficient chemical structure
CN113248483APending Publication Date: 2021-08-13GUANGXI MEDICAL UNIVERSITY
6 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
GUANGXI MEDICAL UNIVERSITY
Publication Date
2021-08-13

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method and application of a flavonoid glycoside monomer isovitexin of Hydrocotyle sibthorpioides. The method comprises the following steps: 1) adding Hydrocotyle sibthorpioides into an ethanol solution, performing ultrasonic extraction, then performing digestion with the ethanol solution multiple times, and performing vacuum concentration until ethanol is completely volatilized to obtain a crude ethanol extract; 2) sequentially extracting the crude ethanol extract with petroleum ether, chloroform and ethyl acetate, and successively conducting concentrating and drying to obtain an ethyl acetate extract; and 3) carrying out silica gel column chromatographic separation on the ethyl acetate extract, carrying out gradient elution with ethyl acetate, methanol and formic acid successively, collecting eluate, and performing recrystallizing with methanol to obtain a product. According to the application, the isovitexin is used for preparing a medicine used for preventing and treating the non-alcoholic fatty liver disease, and the protection mechanism of the isovitexin is inflammation prevention, anti-oxidative stress, lipid peroxidation and down-regulation of endoplasmic reticulum stress related protein expression. The invention provides a novel compound with a clear structure and high efficiency for the treatment of the non-alcoholic fatty liver disease, and develops a new medication approach.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of natural extracts, in particular to a preparation method and application of isovitexin, a flavonoid glycoside monomer of coriander coriander. Background technique

[0002] Hydrocotyle sibthorpioides Lam. is a plant of the genus Hydrocotyle sibthorpioides Lam. The whole herb is used as medicine, which has the functions of clearing away heat and dampness, detoxifying and reducing swelling. Isovitexin is one of the important medicinal ingredients contained in coriander. In the prior art, for example, patent document CN106008483A discloses a method for extracting isovitexin from mung beans and the application of isovitexin in the preparation of cardioprotective drugs. Another example is the patent document CN109232548B, which discloses a method for extracting high-purity vitexin and isovitexin from sandalwood leaves. Another example is the patent document CN105085498B, which discloses a method for extracting...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More