Application of FAM84B in preparation of reagent for prognosis evaluation of esophageal squamous cell carcinoma and in screening of drugs for targeted treatment of esophageal squamous cell carcinoma

A technology for esophageal squamous cell carcinoma and prognosis assessment, applied in the field of biomedicine, can solve the problems of patients' survival prognosis and unclear specific mechanism of action

Active Publication Date: 2021-08-17
SHANXI MEDICAL UNIV
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Problems solved by technology

Recently, the largest genome-wide data of esophageal squamous cell carcinoma in my country has been released. After copy number variation analysis, it was found that FAM84B was significantly amplified in patients with esophageal squamous cell carcinoma, but the survival prognosis of patients and the specific mechanism of action are still unclear

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  • Application of FAM84B in preparation of reagent for prognosis evaluation of esophageal squamous cell carcinoma and in screening of drugs for targeted treatment of esophageal squamous cell carcinoma
  • Application of FAM84B in preparation of reagent for prognosis evaluation of esophageal squamous cell carcinoma and in screening of drugs for targeted treatment of esophageal squamous cell carcinoma
  • Application of FAM84B in preparation of reagent for prognosis evaluation of esophageal squamous cell carcinoma and in screening of drugs for targeted treatment of esophageal squamous cell carcinoma

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[0032] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are part of the embodiments of the present invention, rather than All the embodiments; based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts all belong to the protection scope of the present invention.

[0033] 1. Experimental materials

[0034] 1. Research objects: 507 cases of esophageal squamous cell carcinoma tissues and paired paracancerous tissues used in the present invention were collected from Shanxi Provincial Cancer Hospital and the Affiliated Cancer Hospital of Xinjiang Medical University in the high-incidence area of ​​esophageal cancer in China. Surgical resection was performed for the first t...

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Abstract

The invention belongs to the technical field of biological medicines, aims to clarify a relationship between FAM84B copy number change and prognosis of patients with esophageal squamous cell carcinoma and demonstrate an action mechanism of FAM84B in occurrence and development of esophageal squamous cell carcinoma and an effect of FAM84B in screening of drugs for targeted treatment of esophageal squamous cell carcinoma, and provides application of FAM84B in preparation of a reagent for prognosis evaluation of esophageal squamous cell carcinoma and screening of the drugs for targeted treatment of esophageal squamous cell carcinoma. The invention discloses application of copy number amplification and high expression of the FAM84B gene in preparation of the reagent for prognosis evaluation of esophageal squamous cell carcinoma. The copy number amplification of the FAM84B gene becomes a new index for the prognosis of the patients with esophageal squamous cell carcinoma. The amplification of the copy number of the FAM84B gene causes the increase of the expression of the esophageal squamous carcinoma FAM84B, and the high expression of the FAM84B can promote the proliferation and cycle of esophageal squamous carcinoma cells; and the low expression of the FAM84B can inhibit the proliferation and cycle of esophageal squamous carcinoma cells and block the cells in a G1 phase.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of FAM84B in the preparation of reagents for evaluating the prognosis of esophageal squamous cell carcinoma and the screening of drugs for targeted treatment of esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is one of the most common malignant tumors in the world, with 478,000 new cases and 375,000 deaths every year. China is a country with a high incidence of esophageal cancer, and its morbidity and mortality rank third and fourth among all kinds of malignant tumors, respectively. Different from western countries, 90% of the histological types of esophageal cancer in China are squamous cell carcinoma. Due to the hidden early symptoms of esophageal cancer, most patients are already in the middle and late stage of the disease when they see a doctor. At present, surgery is the main treatment for esophageal cancer,...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/136C12Q2600/112C12Q2600/158Y02A50/30
Inventor 崔永萍程彩霞王芳周延成晓龙李泓漪陈菲
Owner SHANXI MEDICAL UNIV
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